pyrF

Functionⁱ

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityⁱ

Orotidine 5'-phosphate = UMP + CO₂.UniRule annotation

Pathwayⁱ: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Orotate phosphoribosyltransferase (pyrE)
Orotidine 5'-phosphate decarboxylase (pyrF)

This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	17	SubstrateUniRule annotation	1
Binding siteⁱ	39	SubstrateUniRule annotation	1
Active siteⁱ	68	Proton donorUniRule annotation	1
Binding siteⁱ	125	SubstrateUniRule annotation	1
Binding siteⁱ	187	SubstrateUniRule annotation	1
Binding siteⁱ	196	SubstrateUniRule annotation	1
Binding siteⁱ	216	Substrate; via amide nitrogenUniRule annotation	1
Binding siteⁱ	217	SubstrateUniRule annotation	1

GO - Molecular functionⁱ

orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Decarboxylase, Lyase
Biological process	Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayⁱ	UPA00070; UER00120.

UniPathwayⁱ

UPA00070; UER00120.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation) Alternative name(s): OMP decarboxylaseUniRule annotation Short name: OMPDCaseUniRule annotation Short name: OMPdecaseUniRule annotation
Gene namesⁱ	Name:pyrFUniRule annotation Ordered Locus Names:bbp_251
Organismⁱ	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifierⁱ	224915 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Erwiniaceae › Buchnera › Buchnera aphidicola ›
Proteomesⁱ	UP000000601 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000134534	1 – 236	Orotidine 5'-phosphate decarboxylaseAdd BLAST		236

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	224915.bbp251.

STRINGⁱ

224915.bbp251.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q89AL6.
SMRⁱ	Q89AL6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	66 – 75	Substrate bindingUniRule annotation		10

Sequence similaritiesⁱ

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4106EG9. Bacteria. COG0284. LUCA.
KEGG Orthology (KO) More...KOⁱ	K01591.
OMAⁱ	NFKIFLD.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0256.

Family and domain databases

Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_01200_B. OMPdecase_type1_B. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR014732. OMPdecase. IPR018089. OMPdecase_AS. IPR001754. OMPdeCOase_dom. IPR011060. RibuloseP-bd_barrel.
PANTHERⁱ	PTHR32119:SF4. PTHR32119:SF4. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00215. OMPdecase. 1 hit.
SMARTⁱ	View protein in SMART SM00934. OMPdecase. 1 hit.
SUPFAMⁱ	SSF51366. SSF51366. 1 hit.
TIGRFAMsⁱ	TIGR01740. pyrF. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00156. OMPDECASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q89AL6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHLKSNFKNI NIIIALDFFD ENKAMKFIYN LNPTIYALKI GNIMFTLFGV 
        60         70         80         90        100
RFIKILQKLG FKIFLDLKFY DIPNTIFGAI QAVANLNIWM VSIHISGGIQ 
       110        120        130        140        150
MLKSARLALK PFKNKPLLMG VTILTSLDKT DMSKLGIQIS LSKYILSLAK 
       160        170        180        190        200
IAHKCNLDGI ICSGTEISNI KKHINVKNFK ILTPGIRLNG CSSNDQKNVT 
       210        220        230 
TPMLAKQYNV DYIIIGRIVT SSQNPLKTLE LIRSQI

Length:236

Mass (Da):26,565

Last modified:May 23, 2003 - v1

Checksum:ⁱ3F730373627D2E9D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE016826 Genomic DNA. Translation: AAO26978.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011091379.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAO26978; AAO26978; bbp_251.
KEGGⁱ	bab:bbp_251.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE016826 Genomic DNA. Translation: AAO26978.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011091379.1. NC_004545.1.

3D structure databases

ProteinModelPortalⁱ	Q89AL6.
SMRⁱ	Q89AL6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	224915.bbp251.

STRINGⁱ

224915.bbp251.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAO26978; AAO26978; bbp_251.
KEGGⁱ	bab:bbp_251.

Phylogenomic databases

eggNOGⁱ	ENOG4106EG9. Bacteria. COG0284. LUCA.
KEGG Orthology (KO) More...KOⁱ	K01591.
OMAⁱ	NFKIFLD.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0256.

Enzyme and pathway databases

UniPathwayⁱ	UPA00070; UER00120.

UniPathwayⁱ

UPA00070; UER00120.

Family and domain databases

Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_01200_B. OMPdecase_type1_B. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR014732. OMPdecase. IPR018089. OMPdecase_AS. IPR001754. OMPdeCOase_dom. IPR011060. RibuloseP-bd_barrel.
PANTHERⁱ	PTHR32119:SF4. PTHR32119:SF4. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00215. OMPdecase. 1 hit.
SMARTⁱ	View protein in SMART SM00934. OMPdecase. 1 hit.
SUPFAMⁱ	SSF51366. SSF51366. 1 hit.
TIGRFAMsⁱ	TIGR01740. pyrF. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00156. OMPDECASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PYRF_BUCBP
Accessionⁱ	Q89AL6Primary (citable) accession number: Q89AL6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
	Last sequence update:	May 23, 2003
	Last modified:	June 7, 2017
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q89AL6 (PYRF_BUCBP)

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Orotidine 5'-phosphate decarboxylase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UMP biosynthesis via de novo pathway

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: UMP biosynthesis via de novo pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ