UniProtKB - Q89AL6 (PYRF_BUCBP)
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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Functioni
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation
Catalytic activityi
Orotidine 5'-phosphate = UMP + CO2.UniRule annotation
: UMP biosynthesis via de novo pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Orotate phosphoribosyltransferase (pyrE)
- Orotidine 5'-phosphate decarboxylase (pyrF)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 17 | SubstrateUniRule annotation | 1 | |
Binding sitei | 39 | SubstrateUniRule annotation | 1 | |
Active sitei | 68 | Proton donorUniRule annotation | 1 | |
Binding sitei | 125 | SubstrateUniRule annotation | 1 | |
Binding sitei | 187 | SubstrateUniRule annotation | 1 | |
Binding sitei | 196 | SubstrateUniRule annotation | 1 | |
Binding sitei | 216 | Substrate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 217 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC
GO - Biological processi
- 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
- 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Pyrimidine biosynthesis |
Enzyme and pathway databases
BioCyci | BAPH224915:G1G09-255-MONOMER. |
UniPathwayi | UPA00070; UER00120. |
Names & Taxonomyi
Protein namesi | Recommended name: Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)Alternative name(s): OMP decarboxylaseUniRule annotation Short name: OMPDCaseUniRule annotation Short name: OMPdecaseUniRule annotation |
Gene namesi | Name:pyrFUniRule annotation Ordered Locus Names:bbp_251 |
Organismi | Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) |
Taxonomic identifieri | 224915 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Erwiniaceae › Buchnera › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000134534 | 1 – 236 | Orotidine 5'-phosphate decarboxylaseAdd BLAST | 236 |
Interactioni
Subunit structurei
Homodimer.UniRule annotation
Protein-protein interaction databases
STRINGi | 224915.bbp251. |
Structurei
3D structure databases
ProteinModelPortali | Q89AL6. |
SMRi | Q89AL6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 66 – 75 | Substrate bindingUniRule annotation | 10 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4106EG9. Bacteria. COG0284. LUCA. |
KOi | K01591. |
OMAi | NFKIFLD. |
OrthoDBi | POG091H0256. |
Family and domain databases
Gene3Di | 3.20.20.70. 1 hit. |
HAMAPi | MF_01200_B. OMPdecase_type1_B. 1 hit. |
InterProi | View protein in InterPro IPR013785. Aldolase_TIM. IPR014732. OMPdecase. IPR018089. OMPdecase_AS. IPR001754. OMPdeCOase_dom. IPR011060. RibuloseP-bd_barrel. |
PANTHERi | PTHR32119:SF2. PTHR32119:SF2. 1 hit. |
Pfami | View protein in Pfam PF00215. OMPdecase. 1 hit. |
SMARTi | View protein in SMART SM00934. OMPdecase. 1 hit. |
SUPFAMi | SSF51366. SSF51366. 1 hit. |
TIGRFAMsi | TIGR01740. pyrF. 1 hit. |
PROSITEi | View protein in PROSITE PS00156. OMPDECASE. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q89AL6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHLKSNFKNI NIIIALDFFD ENKAMKFIYN LNPTIYALKI GNIMFTLFGV
60 70 80 90 100
RFIKILQKLG FKIFLDLKFY DIPNTIFGAI QAVANLNIWM VSIHISGGIQ
110 120 130 140 150
MLKSARLALK PFKNKPLLMG VTILTSLDKT DMSKLGIQIS LSKYILSLAK
160 170 180 190 200
IAHKCNLDGI ICSGTEISNI KKHINVKNFK ILTPGIRLNG CSSNDQKNVT
210 220 230
TPMLAKQYNV DYIIIGRIVT SSQNPLKTLE LIRSQI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE016826 Genomic DNA. Translation: AAO26978.1. |
RefSeqi | WP_011091379.1. NC_004545.1. |
Genome annotation databases
EnsemblBacteriai | AAO26978; AAO26978; bbp_251. |
KEGGi | bab:bbp_251. |
Similar proteinsi
Entry informationi
Entry namei | PYRF_BUCBP | |
Accessioni | Q89AL6Primary (citable) accession number: Q89AL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 23, 2003 |
Last sequence update: | May 23, 2003 | |
Last modified: | February 28, 2018 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |