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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei17SubstrateUniRule annotation1
Binding sitei39SubstrateUniRule annotation1
Active sitei68Proton donorUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei196SubstrateUniRule annotation1
Binding sitei216Substrate; via amide nitrogenUniRule annotation1
Binding sitei217SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:bbp_251
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001345341 – 236Orotidine 5'-phosphate decarboxylaseAdd BLAST236

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224915.bbp251.

Structurei

3D structure databases

ProteinModelPortaliQ89AL6.
SMRiQ89AL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 75Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9. Bacteria.
COG0284. LUCA.
KOiK01591.
OMAiNFKIFLD.
OrthoDBiPOG091H0256.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
PANTHERiPTHR32119:SF4. PTHR32119:SF4. 1 hit.
PfamiView protein in Pfam
PF00215. OMPdecase. 1 hit.
SMARTiView protein in SMART
SM00934. OMPdecase. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiView protein in PROSITE
PS00156. OMPDECASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89AL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLKSNFKNI NIIIALDFFD ENKAMKFIYN LNPTIYALKI GNIMFTLFGV
60 70 80 90 100
RFIKILQKLG FKIFLDLKFY DIPNTIFGAI QAVANLNIWM VSIHISGGIQ
110 120 130 140 150
MLKSARLALK PFKNKPLLMG VTILTSLDKT DMSKLGIQIS LSKYILSLAK
160 170 180 190 200
IAHKCNLDGI ICSGTEISNI KKHINVKNFK ILTPGIRLNG CSSNDQKNVT
210 220 230
TPMLAKQYNV DYIIIGRIVT SSQNPLKTLE LIRSQI
Length:236
Mass (Da):26,565
Last modified:May 23, 2003 - v1
Checksum:i3F730373627D2E9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO26978.1.
RefSeqiWP_011091379.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO26978; AAO26978; bbp_251.
KEGGibab:bbp_251.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPYRF_BUCBP
AccessioniPrimary (citable) accession number: Q89AL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families