Q89AJ7 (ODO1_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxoglutarate dehydrogenase
EC=1.2.4.2

Gene names

Name:	sucA
Ordered Locus Names:	bbp_280

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]

Taxonomic identifier

224915 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Baizongia pistaciae)

Protein attributes

Sequence length	916 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 916	916	Oxoglutarate dehydrogenase		PRO_0000162189

Sequences

	Sequence		Length	Mass (Da)
	Q89AJ7 [UniParc]. Last modified June 16, 2003. Version 1. Checksum: 9421601E0BE528CB	FASTA	916	106,047
	10 20 30 40 50 60 MYKNEFNSSW MSSFNSSYID NLYNKFLLDP TSIDNSWYIV FTELSKENYI NSTNKYLNNK 70 80 90 100 110 120 FQDSKDTIKL TIELLINIFR TLGYKFAHLN PLDTFKNDNS LSLKKFLKSS EAFRIQDSYL 130 140 150 160 170 180 VKLSQYVLDD ITTKNVYDDY KNIYCKRIGY QFMHIHNSNE MNWIKNYIET KHSNILKKKK 190 200 210 220 230 240 KIQILKHLII SEMLEKYFSS KFPSIKRFSI EGAESLIPML KEVIKYTKKF NLHKIIFGMS 250 260 270 280 290 300 HRGRLNVLAN ILDKPIKTIF NEFCENNSNN FNSGDVKYHM GFCCTKTIGL RKIILDLKSN 310 320 330 340 350 360 PSHLEVINPV VVGSSRAYID SNDNLNDENI LPIIIHGDAA ISGQGVVQEL LNMSQARGYK 370 380 390 400 410 420 VGGTIHIVVN NQIGFTTSKV KDLRTSQYCT DIAKMIDSPI FHVNADDPES VIFVTHLALN 430 440 450 460 470 480 YRFCFKKDVF INLVCYRRHG HNEIDDPSIT QPVLYSKIKN HPTTATSYYN KLLLKNIINK 490 500 510 520 530 540 SFLITYQKKI KKKLDVEYNL HNKKMSEKRL KCCSIVKADY INVSNTPINN ISQSDLTILA 550 560 570 580 590 600 KKIFSIPNNI EVHNRVFKIY KDRLKMANNE KLFDWGASEL LAYASLLNEG ISCRLSGEDV 610 620 630 640 650 660 CRGTFFHRHA VIHDQKNDSK YIPLKNIKLK QGNFYIWDSV LSEEATLAFE YGYSIDQKNT 670 680 690 700 710 720 LNVWEAQFGD FANGAQIIID QFICSGEQKW NVTCNLVMLL PHGYEGQGPE HSSARIERYL 730 740 750 760 770 780 QLSANNNIKI IIPTISSQIY HIIRKQAFSL IKKPLIIMSP KSLLRFPLAA SSLSELSNGK 790 800 810 820 830 840 FRTVIDEIDN LDTKKVQRII LCSGKIYYDL LTQRRINQQK NIVILRIEQI YPRPTKKLSA 850 860 870 880 890 900 ILYNYKDVHD YIWCQEEPCN QGAWLYHKSY LKKLLPKHSK LNYVGRSSSA SPATGYMKIH 910 KEQQKKIIYD ALNISD

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO27005.1.
RefSeq	NP_777900.1. NC_004545.1.
3D structure databases
ProteinModelPortal	Q89AJ7.
ModBase	Search...
Protein-protein interaction databases
STRING	224915.bbp280.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO27005; AAO27005; bbp_280.
GeneID	1058600.
KEGG	bab:bbp280.
PATRIC	21245347. VBIBucAph80364_0276.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
KO	K00164.
OMA	QEVQKYP.
ProtClustDB	PRK09404.
Enzyme and pathway databases
BioCyc	BAPH224915:GJ9D-280-MONOMER.
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_BUCBP

Accession

Primary (citable) accession number: Q89AJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	June 16, 2003
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program