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Protein

Oxoglutarate dehydrogenase

Gene

sucA

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-280-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxoglutarate dehydrogenase (EC:1.2.4.2)
Gene namesi
Name:sucA
Ordered Locus Names:bbp_280
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 916916Oxoglutarate dehydrogenasePRO_0000162189Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224915.bbp280.

Structurei

3D structure databases

ProteinModelPortaliQ89AJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiNFTQPLM.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89AJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKNEFNSSW MSSFNSSYID NLYNKFLLDP TSIDNSWYIV FTELSKENYI
60 70 80 90 100
NSTNKYLNNK FQDSKDTIKL TIELLINIFR TLGYKFAHLN PLDTFKNDNS
110 120 130 140 150
LSLKKFLKSS EAFRIQDSYL VKLSQYVLDD ITTKNVYDDY KNIYCKRIGY
160 170 180 190 200
QFMHIHNSNE MNWIKNYIET KHSNILKKKK KIQILKHLII SEMLEKYFSS
210 220 230 240 250
KFPSIKRFSI EGAESLIPML KEVIKYTKKF NLHKIIFGMS HRGRLNVLAN
260 270 280 290 300
ILDKPIKTIF NEFCENNSNN FNSGDVKYHM GFCCTKTIGL RKIILDLKSN
310 320 330 340 350
PSHLEVINPV VVGSSRAYID SNDNLNDENI LPIIIHGDAA ISGQGVVQEL
360 370 380 390 400
LNMSQARGYK VGGTIHIVVN NQIGFTTSKV KDLRTSQYCT DIAKMIDSPI
410 420 430 440 450
FHVNADDPES VIFVTHLALN YRFCFKKDVF INLVCYRRHG HNEIDDPSIT
460 470 480 490 500
QPVLYSKIKN HPTTATSYYN KLLLKNIINK SFLITYQKKI KKKLDVEYNL
510 520 530 540 550
HNKKMSEKRL KCCSIVKADY INVSNTPINN ISQSDLTILA KKIFSIPNNI
560 570 580 590 600
EVHNRVFKIY KDRLKMANNE KLFDWGASEL LAYASLLNEG ISCRLSGEDV
610 620 630 640 650
CRGTFFHRHA VIHDQKNDSK YIPLKNIKLK QGNFYIWDSV LSEEATLAFE
660 670 680 690 700
YGYSIDQKNT LNVWEAQFGD FANGAQIIID QFICSGEQKW NVTCNLVMLL
710 720 730 740 750
PHGYEGQGPE HSSARIERYL QLSANNNIKI IIPTISSQIY HIIRKQAFSL
760 770 780 790 800
IKKPLIIMSP KSLLRFPLAA SSLSELSNGK FRTVIDEIDN LDTKKVQRII
810 820 830 840 850
LCSGKIYYDL LTQRRINQQK NIVILRIEQI YPRPTKKLSA ILYNYKDVHD
860 870 880 890 900
YIWCQEEPCN QGAWLYHKSY LKKLLPKHSK LNYVGRSSSA SPATGYMKIH
910
KEQQKKIIYD ALNISD
Length:916
Mass (Da):106,047
Last modified:June 16, 2003 - v1
Checksum:i9421601E0BE528CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO27005.1.
RefSeqiNP_777900.1. NC_004545.1.
WP_011091406.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO27005; AAO27005; bbp_280.
KEGGibab:bbp280.
PATRICi21245347. VBIBucAph80364_0276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO27005.1.
RefSeqiNP_777900.1. NC_004545.1.
WP_011091406.1. NC_004545.1.

3D structure databases

ProteinModelPortaliQ89AJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224915.bbp280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO27005; AAO27005; bbp_280.
KEGGibab:bbp280.
PATRICi21245347. VBIBucAph80364_0276.

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiNFTQPLM.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-280-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiODO1_BUCBP
AccessioniPrimary (citable) accession number: Q89AJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: April 29, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.