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Q89AI8

- KPYK_BUCBP

UniProt

Q89AI8 - KPYK_BUCBP

Protein

Pyruvate kinase

Gene

pykA

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.By similarity
    Potassium.By similarity

    Enzyme regulationi

    Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateBy similarity
    Metal bindingi38 – 381PotassiumBy similarity
    Metal bindingi40 – 401PotassiumBy similarity
    Metal bindingi70 – 701PotassiumBy similarity
    Sitei223 – 2231Transition state stabilizerBy similarity
    Metal bindingi225 – 2251MagnesiumBy similarity
    Binding sitei251 – 2511Substrate; via amide nitrogenBy similarity
    Metal bindingi252 – 2521MagnesiumBy similarity
    Binding sitei252 – 2521Substrate; via amide nitrogenBy similarity
    Binding sitei284 – 2841SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-297-MONOMER.
    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pykA
    Ordered Locus Names:bbp_297
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Pyruvate kinasePRO_0000112060Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi224915.bbp297.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89AI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    KOiK00873.
    OMAiTPVYFDS.
    OrthoDBiEOG6GBMB0.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89AI8-1 [UniParc]FASTAAdd to Basket

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    MIRRFRRTKI VATLGPSTDN HIILENMIKS GVNVFRLNFS HGTREEHIYR    50
    AKLVTSIAKR LNCHIALLGD LQGPKIRICK FQDKKVFLKV NNYFILDANL 100
    NENLGTSERV GIDYKNLPKD VKKCDILLLD DGKIQLKVIN IVDQEIFTKI 150
    IIGGVLSNNK GINKLGGGLS ARILTKKDKR DIITSIDIGV DYLAVSFPRY 200
    GSDLDHARKC AVKFGSKAKI IAKIERAEAV KDLKIIDEII LASDAIMVAR 250
    GDLGVEIGES ELAGIQKTLI RRARQLNRVV ITATQMMESM INNPMPTRAE 300
    VMDVANAVLD GSDAVMLSAE TASGKYPIET IKVMSKVCMG AEKMPSINVS 350
    QHRIHDKFHD IEEAIAMSAM YAANHLSGIT AIITMTESGK TSLMTSRITS 400
    GLPIFALSSH IQTLKLTALY RGVTPIFFNS SKEGVSAANE VINLLVKRGF 450
    LEPGNLVIIT QGDIMGKVGK TNTSRILKV 479
    Length:479
    Mass (Da):52,698
    Last modified:June 1, 2003 - v1
    Checksum:i674367EACE323020
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27022.1.
    RefSeqiNP_777917.1. NC_004545.1.
    WP_011091423.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO27022; AAO27022; bbp_297.
    GeneIDi1058264.
    KEGGibab:bbp297.
    PATRICi21245381. VBIBucAph80364_0293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27022.1 .
    RefSeqi NP_777917.1. NC_004545.1.
    WP_011091423.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89AI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO27022 ; AAO27022 ; bbp_297 .
    GeneIDi 1058264.
    KEGGi bab:bbp297.
    PATRICi 21245381. VBIBucAph80364_0293.

    Phylogenomic databases

    eggNOGi COG0469.
    KOi K00873.
    OMAi TPVYFDS.
    OrthoDBi EOG6GBMB0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .
    BioCyci BAPH224915:GJ9D-297-MONOMER.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiKPYK_BUCBP
    AccessioniPrimary (citable) accession number: Q89AI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3