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Q89AI7

- G6PD_BUCBP

UniProt

Q89AI7 - G6PD_BUCBP

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481NADPUniRule annotation
    Binding sitei145 – 1451NADPUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation
    Binding sitei213 – 2131SubstrateUniRule annotation
    Binding sitei232 – 2321SubstrateUniRule annotation
    Active sitei237 – 2371Proton acceptorUniRule annotation
    Binding sitei340 – 3401SubstrateUniRule annotation
    Binding sitei345 – 3451SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi90 – 912NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-298-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:bbp_298
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Glucose-6-phosphate 1-dehydrogenasePRO_0000068114Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224915.bbp298.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89AI7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiDSIMEAW.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89AI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNKNSGYDL VIFGAKGDLS CRKLLPSLYQ LEKKNKLCTH TRIIGVGRAN    50
    WDKIIYTNVV YKSLIKFLNE TIIESIWKKF SSRLEFCNLD INCLHNFKKL 100
    KQIIQQNNNI IINYLAMPPH TFGNICLGLE SINLNLEPTR IIIEKPLGSS 150
    LKTSININNK IGKFFKEKQI FRIDHYLGKE TIQNLLAFRF SNSLFYYNWN 200
    NKFIDHVQIT VSETIGVEGR FNYFDTVGQI KDMVQNHLLQ ILTITTMSTP 250
    IDCHENSIRD EKVKILKSLR PFNINNIHKN VILGQYTSGI INQKKVKSYL 300
    DETNNQEYQM NKYTETFVSM KIYIDNDQWS GVPFYLRTGK RLPKKCSEIV 350
    IFFKTPPLNI FSKNYNTLSK NKLILSLQPN EAIKIYILNK KPKLTSQYKL 400
    DLITLDFNYS KFYKKIQLSD AYEKLLLESM KGIQSLFVRR DEVELAWKWI 450
    DSTLQCLHLK PRLPDLYPAG TWGPARSKTM INNDGYEWNE 490
    Length:490
    Mass (Da):57,318
    Last modified:June 1, 2003 - v1
    Checksum:iF5EE7D9055965AD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27023.1.
    RefSeqiNP_777918.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO27023; AAO27023; bbp_298.
    GeneIDi1058476.
    KEGGibab:bbp298.
    PATRICi21245383. VBIBucAph80364_0294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27023.1 .
    RefSeqi NP_777918.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89AI7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO27023 ; AAO27023 ; bbp_298 .
    GeneIDi 1058476.
    KEGGi bab:bbp298.
    PATRICi 21245383. VBIBucAph80364_0294.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi DSIMEAW.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci BAPH224915:GJ9D-298-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiG6PD_BUCBP
    AccessioniPrimary (citable) accession number: Q89AI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3