Reviewed, UniProtKB/Swiss-Prot Q89AI7 (G6PD_BUCBP)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	bbp_298

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068114
Sites
	Active site	237	1	Proton acceptor By similarity
	Binding site	16	1	NADP By similarity
	Binding site	48	1	NADP By similarity
	Binding site	175	1	Substrate By similarity
	Binding site	179	1	Substrate By similarity
	Binding site	345	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q89AI7-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F5EE7D9055965AD9	FASTA	490	57,318
	10 20 30 40 50 60 MKNKNSGYDL VIFGAKGDLS CRKLLPSLYQ LEKKNKLCTH TRIIGVGRAN WDKIIYTNVV 70 80 90 100 110 120 YKSLIKFLNE TIIESIWKKF SSRLEFCNLD INCLHNFKKL KQIIQQNNNI IINYLAMPPH 130 140 150 160 170 180 TFGNICLGLE SINLNLEPTR IIIEKPLGSS LKTSININNK IGKFFKEKQI FRIDHYLGKE 190 200 210 220 230 240 TIQNLLAFRF SNSLFYYNWN NKFIDHVQIT VSETIGVEGR FNYFDTVGQI KDMVQNHLLQ 250 260 270 280 290 300 ILTITTMSTP IDCHENSIRD EKVKILKSLR PFNINNIHKN VILGQYTSGI INQKKVKSYL 310 320 330 340 350 360 DETNNQEYQM NKYTETFVSM KIYIDNDQWS GVPFYLRTGK RLPKKCSEIV IFFKTPPLNI 370 380 390 400 410 420 FSKNYNTLSK NKLILSLQPN EAIKIYILNK KPKLTSQYKL DLITLDFNYS KFYKKIQLSD 430 440 450 460 470 480 AYEKLLLESM KGIQSLFVRR DEVELAWKWI DSTLQCLHLK PRLPDLYPAG TWGPARSKTM 490 INNDGYEWNE

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO27023.1.
RefSeq	NP_777918.1.
3D structure databases
SMR	Q89AI7. Positions 3-489.
ModBase	Search...
Genome annotation databases
GeneID	1058476.
GenomeReviews	Gene locus bbp_298 in contig AE016826_GR.
KEGG	bab:bbp298.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG322449.
OMA	DNIYENT.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_298-MONOMER.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_BUCBP

Accession

Primary (citable) accession number: Q89AI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)