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Q89AG9

- FABG_BUCBP

UniProt

Q89AG9 - FABG_BUCBP

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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene
fabG, bbp_321
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381NADP By similarity
Metal bindingi51 – 511Calcium 1; via carbonyl oxygen; shared with dimeric partner By similarity
Metal bindingi54 – 541Calcium 1; via carbonyl oxygen; shared with dimeric partner By similarity
Binding sitei87 – 871NADP; via carbonyl oxygen By similarity
Binding sitei139 – 1391Substrate By similarity
Metal bindingi146 – 1461Calcium 2 By similarity
Active sitei152 – 1521Proton acceptor By similarity
Binding sitei185 – 1851NADP; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi234 – 2341Calcium 3; shared with dimeric partner By similarity
Metal bindingi235 – 2351Calcium 3; via carbonyl oxygen; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADP By similarity
Nucleotide bindingi60 – 612NADP By similarity
Nucleotide bindingi152 – 1565NADP By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-321-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:bbp_321
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2452453-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054668Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi224915.bbp321.

Structurei

3D structure databases

ProteinModelPortaliQ89AG9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiEGIEGWI.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89AG9-1 [UniParc]FASTAAdd to Basket

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MKTTKKIAVI TGANRGLGKG IAEELSNTNN ITVIGTSTSQ KGCKIINKYL    50
KNNGIGIKLD ITNPNEITKT MDFVYKNFGR VDILINNAGI IRDKLLINMK 100
TQDWNSVLNV NLNSIFYMSK SVIRNMIKNK QGKIITIGSV IAHIGNCGQT 150
NYSAAKLGLV GFHKSLALEL APKGITVNMI APGLIKTGMT NNLSQKQLSK 200
YLSKIPMKRL GTIKEISKIT LFLISNDANY ITGQVIHVNG GMYMP 245
Length:245
Mass (Da):26,788
Last modified:May 30, 2003 - v1
Checksum:i6B94C5520D69157E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO27043.1.
RefSeqiNP_777938.1. NC_004545.1.
WP_011091444.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO27043; AAO27043; bbp_321.
GeneIDi1058479.
KEGGibab:bbp321.
PATRICi21245431. VBIBucAph80364_0315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO27043.1 .
RefSeqi NP_777938.1. NC_004545.1.
WP_011091444.1. NC_004545.1.

3D structure databases

ProteinModelPortali Q89AG9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO27043 ; AAO27043 ; bbp_321 .
GeneIDi 1058479.
KEGGi bab:bbp321.
PATRICi 21245431. VBIBucAph80364_0315.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi EGIEGWI.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci BAPH224915:GJ9D-321-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiFABG_BUCBP
AccessioniPrimary (citable) accession number: Q89AG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Calcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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