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Q89AG9

- FABG_BUCBP

UniProt

Q89AG9 - FABG_BUCBP

Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (30 May 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381NADPBy similarity
    Metal bindingi51 – 511Calcium 1; via carbonyl oxygen; shared with dimeric partnerBy similarity
    Metal bindingi54 – 541Calcium 1; via carbonyl oxygen; shared with dimeric partnerBy similarity
    Binding sitei87 – 871NADP; via carbonyl oxygenBy similarity
    Binding sitei139 – 1391SubstrateBy similarity
    Metal bindingi146 – 1461Calcium 2By similarity
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation
    Binding sitei185 – 1851NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Metal bindingi234 – 2341Calcium 3; shared with dimeric partnerBy similarity
    Metal bindingi235 – 2351Calcium 3; via carbonyl oxygen; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADPBy similarity
    Nucleotide bindingi60 – 612NADPBy similarity
    Nucleotide bindingi152 – 1565NADPBy similarity

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-321-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
    Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase
    Beta-Ketoacyl-acyl carrier protein reductase
    Beta-ketoacyl-ACP reductase
    Gene namesi
    Name:fabG
    Ordered Locus Names:bbp_321
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2452453-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054668Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi224915.bbp321.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89AG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK00059.
    OMAiEGIEGWI.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89AG9-1 [UniParc]FASTAAdd to Basket

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    MKTTKKIAVI TGANRGLGKG IAEELSNTNN ITVIGTSTSQ KGCKIINKYL    50
    KNNGIGIKLD ITNPNEITKT MDFVYKNFGR VDILINNAGI IRDKLLINMK 100
    TQDWNSVLNV NLNSIFYMSK SVIRNMIKNK QGKIITIGSV IAHIGNCGQT 150
    NYSAAKLGLV GFHKSLALEL APKGITVNMI APGLIKTGMT NNLSQKQLSK 200
    YLSKIPMKRL GTIKEISKIT LFLISNDANY ITGQVIHVNG GMYMP 245
    Length:245
    Mass (Da):26,788
    Last modified:May 30, 2003 - v1
    Checksum:i6B94C5520D69157E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27043.1.
    RefSeqiNP_777938.1. NC_004545.1.
    WP_011091444.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO27043; AAO27043; bbp_321.
    GeneIDi1058479.
    KEGGibab:bbp321.
    PATRICi21245431. VBIBucAph80364_0315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27043.1 .
    RefSeqi NP_777938.1. NC_004545.1.
    WP_011091444.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89AG9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO27043 ; AAO27043 ; bbp_321 .
    GeneIDi 1058479.
    KEGGi bab:bbp321.
    PATRICi 21245431. VBIBucAph80364_0315.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K00059.
    OMAi EGIEGWI.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci BAPH224915:GJ9D-321-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiFABG_BUCBP
    AccessioniPrimary (citable) accession number: Q89AG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: May 30, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Calcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3