PTS system glucose-specific EIICB component - Buchnera aphidicola subsp. Baizongia pistaciae

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Reviewed, UniProtKB/Swiss-Prot Q89AG6 (PTGCB_BUCBP)

Last modified June 16, 2009. Version 49. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    PTS system glucose-specific EIICB component
Alternative name(s):
    EIICB-Glc
      Short name=EII-Glc
Including the following 2 domains:
    1- Recommended name:
            Glucose permease IIC component
        Alternative name(s):
            PTS system glucose-specific EIIC component
    2- Recommended name:
            Glucose-specific phosphotransferase enzyme IIB component
              EC=2.7.1.69
        Alternative name(s):
            PTS system glucose-specific EIIB component

Gene names

Name:	ptsG
Ordered Locus Names:	bbp_326

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

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Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport By similarity.
Catalytic activity	Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Domain	The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
Sequence similarities	Contains 1 PTS EIIB type-1 domain. Contains 1 PTS EIIC type-1 domain.

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Ontologies

Keywords
Biological process	Phosphotransferase system Sugar transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose transport Inferred from electronic annotation. Source: InterPro phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose transmembrane transporter activity Inferred from electronic annotation. Source: InterPro kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Inferred from electronic annotation. Source: EC sugar:hydrogen symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 479

479

PTS system glucose-specific EIICB component

PRO_0000186527

Regions

Transmembrane

15 – 35

Potential

Transmembrane

51 – 71

Potential

Transmembrane

80 – 100

Potential

Transmembrane

112 – 132

Potential

Transmembrane

152 – 172

Potential

Transmembrane

252 – 272

Potential

Transmembrane

280 – 300

Potential

Transmembrane

305 – 325

Potential

Transmembrane

356 – 376

Potential

Domain

1 – 388

388

PTS EIIC type-1

Domain

399 – 479

PTS EIIB type-1

Sites

Active site

421

Phosphocysteine intermediate; for EIIB activity By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q89AG6-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: FF1B60760B4D9ABD
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FASTA

479

52,157

        10         20         30         40         50         60 
MFKNAFSNLQ KIGRSLMLPV SVLPIAGILL GIGSANFKII PHTISNIMTE AGSSVFSNMP 

        70         80         90        100        110        120 
LIFAIGIALG FTKNDGVSAL AAVVSYGIMT KTLSITIPIF SNLSDINVNQ KYLLDTGILG 

       130        140        150        160        170        180 
GIIAGSISAY IFNTFYRIQL PEYLGFFAGR RFVPIASGLI SIIFGCILSI IWPPIGNVIK 

       190        200        210        220        230        240 
TFSEWAAYQN PTLAFGIYGT VERALVPFGL HHIWNVPFQM QIGEYNNSIG QIFHGDIARY 

       250        260        270        280        290        300 
MAGDSTAGKL SGGFIFKMYG LPFAALAMWH CANKKNKAKI GGIMMSGALT AILTGITEPI 

       310        320        330        340        350        360 
EFSFILVAPI LYVIHAILAG LAFPICILLN MRSGTSFSHG LIDFIVLSGN SNNFWLFPIV 

       370        380        390        400        410        420 
GLFYGILYYG IFYFMIKKFN LKTPGREKSI TYINQKTIKE TALLVISILG GKTNIINLDA 

       430        440        450        460        470 
CITRLRITVL DISKVNQKKL KNLGASGVIV SGSGIQIVFG TQSDHIKTEI DNYMSNTNQ

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References

[1]

"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases
	AE016826 Genomic DNA. Translation: AAO27048.1.
RefSeq	NP_777943.1.
3D structure databases
HSSP	HSSP built from PDB template 1O2F based on UniProtKB P05053.
ModBase	Search...
Genome annotation databases
GeneID	1058276.
GenomeReviews	Gene locus bbp_326 in contig AE016826_GR.
KEGG	bab:bbp326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89AG6.
OMA	Q89AG6. NNDGVAG.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_326-MON.
Family and domain databases
InterPro	IPR018113. PTrfase_EIIB/Cys_phospho_site. IPR001996. PTS_EIIB. IPR003352. PTS_EIIC. IPR013013. PTS_EIIC_1. IPR011535. PTS_Glc-like_IIB_component. IPR011299. PTS_IIBC_glc. [Graphical view]
Gene3D	G3DSA:3.30.1360.60. PTS_EIIB. 1 hit.
Pfam	PF00367. PTS_EIIB. 1 hit. PF02378. PTS_EIIC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00826. EIIB_glc. 1 hit. TIGR02002. PTS-II-BC-glcB. 1 hit.
PROSITE	PS51098. PTS_EIIB_TYPE_1. 1 hit. PS01035. PTS_EIIB_TYPE_1_CYS. 1 hit. PS51103. PTS_EIIC_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

PTGCB_BUCBP

Accession

Primary (citable) accession number: Q89AG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents