Q89AD8 (GSH1_BUCBP) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Glutamate--cysteine ligase EC=6.3.2.2 Alternative name(s): Gamma-ECS Short name=GCS Gamma-glutamylcysteine synthetase | ||||
| Gene names |
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| Organism | Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 224915 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera |
Protein attributes
| Sequence length | 521 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. HAMAP MF_00578 |
| Pathway | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. HAMAP MF_00578 |
| Sequence similarities | Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glutathione biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-cysteine ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 521 | 521 | Glutamate--cysteine ligase HAMAP MF_00578 | PRO_0000192522 | |||
Sequences
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References
| [1] | "Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bp. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016826 Genomic DNA. Translation: AAO27085.1. |
| RefSeq | NP_777980.1. NC_004545.1. |
3D structure databases | |
| ProteinModelPortal | Q89AD8. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBUCT00000002493; EBBUCP00000002317; EBBUCG00000002493. |
| GeneID | 1058287. |
| GenomeReviews | Gene locus bbp_368 in contig AE016826_GR. |
| KEGG | bab:bbp368. |
| PATRIC | 21245529. VBIBucAph80364_0361. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000007855. |
| HOGENOM | HBG289023. |
| OMA | FGLIRNY. |
| ProtClustDB | PRK02107. |
Enzyme and pathway databases | |
| BioCyc | BAPH224915:BBP_368-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00578. Glu_cys_ligase. [Tree] |
| InterPro | IPR007370. Glu_cys_ligase. IPR006334. Glut_cys_ligase. [Graphical view] |
| KO | K01919. |
| Pfam | PF04262. Glu_cys_ligase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01434. Glu_cys_ligase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GSH1_BUCBP | ||||||||
| Accession | Primary (citable) accession number: Q89AD8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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