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Reviewed, UniProtKB/Swiss-Prot Q89AD8 (GSH1_BUCBP)

Last modified June 16, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glutamate--cysteine ligase
    EC=6.3.2.2
Alternative name(s):
    Gamma-glutamylcysteine synthetase
    Gamma-ECS
      Short name=GCS
Gene names
Name: gshA
Ordered Locus Names: bbp_368
OrganismBuchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]
Taxonomic identifier135842 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. HAMAP MF_00578

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. HAMAP MF_00578

Sequence similarities

Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-cysteine ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Glutamate--cysteine ligase HAMAP MF_00578
PRO_0000192522

Sequences

Sequence LengthMass (Da)Tools
Q89AD8-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1FD19D58646C89BB

FASTA52161,433
        10         20         30         40         50         60 
MIPKIYKKIK WLQSNPLILK KILRGIEREA LRTDIHGTII NTAYPQDKIG SALTHKWITT 

        70         80         90        100        110        120 
DFSESLLEFI TPTNASTNYI LKFLNDTHKF VNDNLIQEYF WPFSIPPCKK YMHSIKLSKY 

       130        140        150        160        170        180 
GTSNLGQVKT LYRKGLKHRY GILMNIISGV HYNFSLPRIF WNHWKKIHHK NTQYNTTSEG 

       190        200        210        220        230        240 
YLCLIRNYYK FGWIIPYLFG ASPAVEPLFI KNKKHNYKFK KHHGMLYLPW STSLRLSDLG 

       250        260        270        280        290        300 
HTNQSIKKLK LTFNSLSEYV LALEHGIKTP SKQFKNLGLY DQFGNFKQIN TNLLQTENEL 

       310        320        330        340        350        360 
YTYIRPKQKL KNCESLSAAL RNRGIEYVEI RALDINPFTS TGVDKNQILL LDLFLIWCVL 

       370        380        390        400        410        420 
ADSPKISSQE FHFFLKNWHT IITKGRKPKQ KININIYNTK NTIQTIGKTI LYDLFYIAEI 

       430        440        450        460        470        480 
LDSLSNNNNY QETCKNLILY FDYPELTYSE KLLNKFMCYG IYETGANLFV KYKQKLHNDS 

       490        500        510        520 
FKILSKKDLN NEMMKSNNSQ KLIEKQDTLN FKEYLNLYYT K 

« Hide

Cross-references

Sequence databases

AE016826 Genomic DNA. Translation: AAO27085.1.
RefSeqNP_777980.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1058287.
GenomeReviewsGene locus bbp_368 in contig AE016826_GR.
KEGGbab:bbp368.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ89AD8.
OMAQ89AD8. EYIEVRA.

Enzyme and pathway databases

BioCycBAPH224915:BBP_368-MON.

Family and domain databases

HAMAPMF_00578.
[Tree]
InterProIPR007370. Glu_cys_ligase.
IPR006334. Glut_cys_ligase.
[Graphical view]
PfamPF04262. Glu_cys_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01434. glu_cys_ligase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGSH1_BUCBP
AccessionPrimary (citable) accession number: Q89AD8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents