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Q89AB6

- ALF_BUCBP

UniProt

Q89AB6 - ALF_BUCBP

Protein

Fructose-bisphosphate aldolase class 2

Gene

fbaA

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (30 May 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621Glyceraldehyde 3-phosphateBy similarity
    Active sitei110 – 1101Proton donorBy similarity
    Metal bindingi111 – 1111Zinc 1; catalyticBy similarity
    Metal bindingi145 – 1451Zinc 2By similarity
    Metal bindingi175 – 1751Zinc 2By similarity
    Metal bindingi227 – 2271Zinc 1; catalyticBy similarity
    Binding sitei228 – 2281Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi265 – 2651Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-401-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 2 (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Fructose-bisphosphate aldolase class II
    Gene namesi
    Name:fbaA
    Synonyms:fba
    Ordered Locus Names:bbp_401
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Fructose-bisphosphate aldolase class 2PRO_0000178710Add
    BLAST

    Proteomic databases

    PRIDEiQ89AB6.

    Interactioni

    Protein-protein interaction databases

    STRINGi224915.bbp401.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89AB6.
    SMRiQ89AB6. Positions 4-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni266 – 2683Dihydroxyacetone phosphate bindingBy similarity
    Regioni287 – 2904Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    KOiK01624.
    OMAiHNSLDFV.
    OrthoDBiEOG69GZPB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89AB6-1 [UniParc]FASTAAdd to Basket

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    MCNILNKIKP GVITGNEALK LFKIAKKNHF AIPAINCINT DSINIVLETA    50
    KKAKSPVIIQ FSYGGSNFIS GPGLTTNILH KKAIIGALSG ANHVHIMAKH 100
    YNVPVILHTD HCNKNMLPWI DELINVGTKH FKTYNKPLFT SHMIDLSNEK 150
    LDYNINICSK YLEKMRKINM LLEIELGCTG GEEDGINNTK INKSLLYTQP 200
    NEVNYAYERL SSVGPEFIIA ASFGNVHGVY KSGNVRLTPD ILKKSQNYVS 250
    KKHNLSCNPL CFVFHGGSGS SEKDIKKSIK YGVIKMNIDT DIQWATWQGI 300
    LNFYNKNNKY LHNQIGNLDN ENKPNKKYYD PRTWIRSSQI SVSNHLTKIF 350
    RILNSCNTL 359
    Length:359
    Mass (Da):40,487
    Last modified:May 30, 2003 - v1
    Checksum:i49DE95BCADB14B5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27113.1.
    RefSeqiNP_778008.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO27113; AAO27113; bbp_401.
    GeneIDi1058292.
    KEGGibab:bbp401.
    PATRICi21245605. VBIBucAph80364_0396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27113.1 .
    RefSeqi NP_778008.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89AB6.
    SMRi Q89AB6. Positions 4-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp401.

    Proteomic databases

    PRIDEi Q89AB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO27113 ; AAO27113 ; bbp_401 .
    GeneIDi 1058292.
    KEGGi bab:bbp401.
    PATRICi 21245605. VBIBucAph80364_0396.

    Phylogenomic databases

    eggNOGi COG0191.
    KOi K01624.
    OMAi HNSLDFV.
    OrthoDBi EOG69GZPB.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci BAPH224915:GJ9D-401-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiALF_BUCBP
    AccessioniPrimary (citable) accession number: Q89AB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: May 30, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3