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Protein

Multidrug resistance-like ATP-binding protein MdlA

Gene

mdlA

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi370 – 377ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-like ATP-binding protein MdlA (EC:3.6.3.44)
Gene namesi
Name:mdlA
Ordered Locus Names:bbp_423
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000601 Componenti: Chromosome

Subcellular locationi

Q89A97:

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei53 – 73HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei134 – 154HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei155 – 175HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei247 – 267HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei281 – 301HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924951 – 579Multidrug resistance-like ATP-binding protein MdlAAdd BLAST579

Interactioni

Protein-protein interaction databases

STRINGi224915.bbp423.

Structurei

3D structure databases

ProteinModelPortaliQ89A97.
SMRiQ89A97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 303ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST286
Domaini338 – 572ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK18889.
OMAiRMAVDMR.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89A97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLLKQLKWY FIQEYKNYTI AIFLLISISI LQLYPPKLIG MLIDISIRKQ
60 70 80 90 100
TQKAPILPLI LIILFISIII YILRYMWRLF LFGASYKLAI KLRIEIYNYL
110 120 130 140 150
CQQKNDFYLK HKTGDLIARI TNDVDKVVFA AGEGVLTLVD SLIMGVSVII
160 170 180 190 200
VMITQISWKL TIISLIPMPI MAIIIKRFGK KLYSSYHDAQ TTFSHLNNYA
210 220 230 240 250
QENLNNIHMI KAFGLENYYS KKFLKIAHKT RKKNIKIAKI DSKFNPIIHL
260 270 280 290 300
FISISHLLAI TIGSYMITYN EISTGELMSF ILYLGLIIWP MLAFAWMFNI
310 320 330 340 350
IERGSASWDR IKSMINNNLF IHKKKYKNIS NIPGILEVKI NYFKYSKSNK
360 370 380 390 400
TILKNINFKI RPGQILGICG PTGSGKSTLL KLIQRQIELY DGKISYHSIP
410 420 430 440 450
ITQFNIVEWR KKMSIVNQTT FLFSDTIANN IKLGKPYASQ KEIEQATTFS
460 470 480 490 500
DLHNDIMTFP QGYNTQVGER GIMLSGGQKQ RISIARALLL KSEILILDNA
510 520 530 540 550
LSSVDNKTEI NILENLKTWK KNKNTIIMCT HRLSSLINSD LIIVIENGSI
560 570
TQIGKHKLLI QNLKQWYGKT YLHQKLSNH
Length:579
Mass (Da):66,819
Last modified:May 30, 2003 - v1
Checksum:iC75716750E436780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016826 Genomic DNA. Translation: AAO27133.1.
RefSeqiWP_011091534.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO27133; AAO27133; bbp_423.
KEGGibab:bbp_423.

Similar proteinsi

Entry informationi

Entry nameiMDLA_BUCBP
AccessioniPrimary (citable) accession number: Q89A97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families