Q89A97 (MDLA_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multidrug resistance-like ATP-binding protein MdlA
EC=3.6.3.44

Gene names

Name:	mdlA
Ordered Locus Names:	bbp_423

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]

Taxonomic identifier

224915 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 579	579	Multidrug resistance-like ATP-binding protein MdlA		PRO_0000092495
Regions
	Transmembrane	20 – 40	21	Helical; Potential
	Transmembrane	53 – 73	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Transmembrane	247 – 267	21	Helical; Potential
	Transmembrane	281 – 301	21	Helical; Potential
	Domain	18 – 303	286	ABC transmembrane type-1
	Domain	338 – 572	235	ABC transporter
	Nucleotide binding	370 – 377	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q89A97 [UniParc]. Last modified May 30, 2003. Version 1. Checksum: C75716750E436780	FASTA	579	66,819
	10 20 30 40 50 60 MQLLKQLKWY FIQEYKNYTI AIFLLISISI LQLYPPKLIG MLIDISIRKQ TQKAPILPLI 70 80 90 100 110 120 LIILFISIII YILRYMWRLF LFGASYKLAI KLRIEIYNYL CQQKNDFYLK HKTGDLIARI 130 140 150 160 170 180 TNDVDKVVFA AGEGVLTLVD SLIMGVSVII VMITQISWKL TIISLIPMPI MAIIIKRFGK 190 200 210 220 230 240 KLYSSYHDAQ TTFSHLNNYA QENLNNIHMI KAFGLENYYS KKFLKIAHKT RKKNIKIAKI 250 260 270 280 290 300 DSKFNPIIHL FISISHLLAI TIGSYMITYN EISTGELMSF ILYLGLIIWP MLAFAWMFNI 310 320 330 340 350 360 IERGSASWDR IKSMINNNLF IHKKKYKNIS NIPGILEVKI NYFKYSKSNK TILKNINFKI 370 380 390 400 410 420 RPGQILGICG PTGSGKSTLL KLIQRQIELY DGKISYHSIP ITQFNIVEWR KKMSIVNQTT 430 440 450 460 470 480 FLFSDTIANN IKLGKPYASQ KEIEQATTFS DLHNDIMTFP QGYNTQVGER GIMLSGGQKQ 490 500 510 520 530 540 RISIARALLL KSEILILDNA LSSVDNKTEI NILENLKTWK KNKNTIIMCT HRLSSLINSD 550 560 570 LIIVIENGSI TQIGKHKLLI QNLKQWYGKT YLHQKLSNH

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO27133.1.
RefSeq	NP_778028.1. NC_004545.1.
3D structure databases
ProteinModelPortal	Q89A97.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000002244; EBBUCP00000002068; EBBUCG00000002244.
GeneID	1058305.
GenomeReviews	Gene locus bbp_423 in contig AE016826_GR.
KEGG	bab:bbp423.
PATRIC	21245663. VBIBucAph80364_0424.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007760.
HOGENOM	HBG758042.
PhylomeDB	Q89A97.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_423-MONOMER.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K06147.
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDLA_BUCBP

Accession

Primary (citable) accession number: Q89A97

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 30, 2003
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program