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Q89A96 (MDLB_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Multidrug resistance-like ATP-binding protein MdlB

EC=3.6.3.44
Gene names
Name:mdlB
Ordered Locus Names:bbp_424
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length578 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 578578Multidrug resistance-like ATP-binding protein MdlB
PRO_0000092501

Regions

Transmembrane26 – 4621Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane196 – 21621Helical; Potential
Transmembrane260 – 28021Helical; Potential
Domain25 – 308284ABC transmembrane type-1
Domain339 – 573235ABC transporter
Nucleotide binding373 – 3808ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q89A96 [UniParc].

Last modified May 30, 2003. Version 1.
Checksum: 3B84848CE196ADF7

FASTA57866,827
        10         20         30         40         50         60 
MNNVIDFWPT LKRLLYYGTN VKKYLILGFT LLLFSSIFEV LNPILISCFI KHYFINNTVN 

        70         80         90        100        110        120 
YSLKIITYYL ILQILAAILN YHQNIIFNKI SLTVIQKLRY DVMSSTLQLP IKMFDQRPIG 

       130        140        150        160        170        180 
QFISRITNDT ETIKELYDTV IKSLFQNIIL ILITLITMFI LEWRMACIAS IIFPIALIIM 

       190        200        210        220        230        240 
LLYQYFSKPI LRKIKVYIAN IYNIFNEIIN GIDVIQQFHQ EQKFRKSIKK ISISHYYFRM 

       250        260        270        280        290        300 
KILKLDSFLL RPLLNFCSTL ILCGLILIFG IYPIGFFEIG TLYAFITYLN RLNEPLITIT 

       310        320        330        340        350        360 
SQQSIFQQAI VAGERIFEII HTPKQQYGDD SLHFREGNIK VKNLYFSYTN NNVYVLKNIN 

       370        380        390        400        410        420 
IFIPSKQFIA FVGRTGSGKS TLSKLLIGHY PATLGKICLD ERNIQTFTHN VLKKNISIVQ 

       430        440        450        460        470        480 
QDPIILNDTI LENITLGRNI STKKVLKILK TIKLIQFVNS LPKGLKTLLG ENGNILSIGQ 

       490        500        510        520        530        540 
KQLLSIARTL ISCPKILILD EATSNVDLDT ENNIKKILSS VKHLTTIIAI THRLSTIKHA 

       550        560        570 
DNIFVFNNGE IVESGTHYNL IRKKSYYKNM YYSQAIKN 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016826 Genomic DNA. Translation: AAO27134.1.
RefSeqNP_778029.1. NC_004545.1.

3D structure databases

ProteinModelPortalQ89A96.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002257; EBBUCP00000002081; EBBUCG00000002257.
GeneID1058630.
GenomeReviewsGene locus bbp_424 in contig AE016826_GR.
KEGGbab:bbp424.
PATRIC21245665. VBIBucAph80364_0425.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007760.
HOGENOMHBG758042.

Enzyme and pathway databases

BioCycBAPH224915:BBP_424-MONOMER.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
KOK06148.
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. False negative.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDLB_BUCBP
AccessionPrimary (citable) accession number: Q89A96
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families