Reviewed, UniProtKB/Swiss-Prot Q89A37 (MTLD_BUCBP)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	bbp_516

Organism

Buchnera aphidicola subsp. Baizongia pistaciae [Complete proteome] [HAMAP]

Taxonomic identifier

135842 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000170701
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q89A37-1 [UniParc]. Last modified May 23, 2003. Version 1. Checksum: B1037CA82DC02E8D	FASTA	390	44,567
	10 20 30 40 50 60 MNALHFGAGN IGRGFIGPLL LKSGFNLTFV DNNQAIVDAI NRHQKYDITV VGNNFSYITT 70 80 90 100 110 120 VKKVKAIYIN DPNIYFKIAK INVITISVGV HAINSLVVFF EKLIRYKIET NDFVFLTIIA 130 140 150 160 170 180 CENVFRCASK LKENIKILLP GIYHKYLDKN ISFVDSVVDK IVCPNDKNNS DDINLSVKVE 190 200 210 220 230 240 KFSEWIVDCT QFKHDRPNII GMIYSNHLDA FFERKLFTLN TGHAIAAYLG LLIGYKNIYQ 250 260 270 280 290 300 AILDPLIFNI VYGAMKESGM VLIRKYNFFT DSEHKNYILK ILSRFKNIYL TDSLKRVGRN 310 320 330 340 350 360 PLQKLKKDDR LISPLIDTIK YNLPNANLMK GIAAALCYID EKDIEAKKLR NMIINKGIKY 370 380 390 VLSKISSLDS SLLIISEISI YFNIFMKVNI

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016826 Genomic DNA. Translation: AAO27219.1.
RefSeq	NP_778114.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1058182.
GenomeReviews	Gene locus bbp_516 in contig AE016826_GR.
KEGG	bab:bbp516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q89A37.
Enzyme and pathway databases
BioCyc	BAPH224915:BBP_516-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BUCBP

Accession

Primary (citable) accession number: Q89A37

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	May 23, 2003
Last modified:	November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)