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Q89A30

- TRPG_BUCBP

UniProt

Q89A30 - TRPG_BUCBP

Protein

Anthranilate synthase component 2

Gene

trpG

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia By similarity.By similarity

    Catalytic activityi

    Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei84 – 841For GATase activityPROSITE-ProRule annotation
    Binding sitei84 – 841GlutamineBy similarity
    Binding sitei88 – 881GlutamineBy similarity
    Active sitei170 – 1701For GATase activityPROSITE-ProRule annotation
    Active sitei172 – 1721For GATase activityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. anthranilate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-KW
    2. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciBAPH224915:GJ9D-525-MONOMER.
    UniPathwayiUPA00035; UER00040.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anthranilate synthase component 2 (EC:4.1.3.27)
    Short name:
    AS
    Short name:
    ASII
    Alternative name(s):
    Anthranilate synthase, GATase component
    Anthranilate synthase, glutamine amidotransferase component
    Gene namesi
    Name:trpG
    Ordered Locus Names:bbp_525
    OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
    Taxonomic identifieri224915 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Anthranilate synthase component 2PRO_0000056874Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).By similarity

    Protein-protein interaction databases

    STRINGi224915.bbp525.

    Structurei

    3D structure databases

    ProteinModelPortaliQ89A30.
    SMRiQ89A30. Positions 2-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 192190Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 593Glutamine bindingBy similarity
    Regioni134 – 1352Glutamine bindingBy similarity

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0512.
    KOiK01658.
    OMAiANPMPVA.
    OrthoDBiEOG6M9F11.

    Family and domain databases

    Gene3Di3.40.50.880. 1 hit.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR006221. TrpG/PapA_dom.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89A30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNILLLDNI DSFTYNLVDQ LRSNFHQVFV YRNTVRKNII LKKLSKMINP    50
    ILILSPGPGN PDNAGCMPQL LMELKGKLPI IGICLGHQAI VKMYGGHVGY 100
    SGEILHGQAS LINHDNKAMF LGMSNPLPVA RYHSLICSNI PNMLVVNAHF 150
    NNMVMAVRND YEKICGFQFH PESILTTRGT EFLQRVIQWT KI 192
    Length:192
    Mass (Da):21,603
    Last modified:June 1, 2003 - v1
    Checksum:iBBE006C1FC39B0BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27227.1.
    RefSeqiNP_778122.1. NC_004545.1.
    WP_011091628.1. NC_004545.1.

    Genome annotation databases

    EnsemblBacteriaiAAO27227; AAO27227; bbp_525.
    GeneIDi1058501.
    KEGGibab:bbp525.
    PATRICi21245873. VBIBucAph80364_0521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016826 Genomic DNA. Translation: AAO27227.1 .
    RefSeqi NP_778122.1. NC_004545.1.
    WP_011091628.1. NC_004545.1.

    3D structure databases

    ProteinModelPortali Q89A30.
    SMRi Q89A30. Positions 2-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224915.bbp525.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO27227 ; AAO27227 ; bbp_525 .
    GeneIDi 1058501.
    KEGGi bab:bbp525.
    PATRICi 21245873. VBIBucAph80364_0521.

    Phylogenomic databases

    eggNOGi COG0512.
    KOi K01658.
    OMAi ANPMPVA.
    OrthoDBi EOG6M9F11.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00040 .
    BioCyci BAPH224915:GJ9D-525-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.880. 1 hit.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR006221. TrpG/PapA_dom.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bp.

    Entry informationi

    Entry nameiTRPG_BUCBP
    AccessioniPrimary (citable) accession number: Q89A30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3