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Q89A30

- TRPG_BUCBP

UniProt

Q89A30 - TRPG_BUCBP

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Protein

Anthranilate synthase component 2

Gene

trpG

Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).By similarity

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841For GATase activityPROSITE-ProRule annotation
Binding sitei84 – 841GlutamineBy similarity
Binding sitei88 – 881GlutamineBy similarity
Active sitei170 – 1701For GATase activityPROSITE-ProRule annotation
Active sitei172 – 1721For GATase activityPROSITE-ProRule annotation

GO - Molecular functioni

  1. anthranilate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-KW
  2. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciBAPH224915:GJ9D-525-MONOMER.
UniPathwayiUPA00035; UER00040.

Protein family/group databases

MEROPSiC26.960.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase component 2 (EC:4.1.3.27)
Short name:
AS
Short name:
ASII
Alternative name(s):
Anthranilate synthase, GATase component
Anthranilate synthase, glutamine amidotransferase component
Gene namesi
Name:trpG
Ordered Locus Names:bbp_525
OrganismiBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Taxonomic identifieri224915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Anthranilate synthase component 2PRO_0000056874Add
BLAST

Interactioni

Subunit structurei

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).By similarity

Protein-protein interaction databases

STRINGi224915.bbp525.

Structurei

3D structure databases

ProteinModelPortaliQ89A30.
SMRiQ89A30. Positions 2-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 192190Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 593Glutamine bindingBy similarity
Regioni134 – 1352Glutamine bindingBy similarity

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0512.
KOiK01658.
OMAiANPMPVA.
OrthoDBiEOG6M9F11.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR006221. TrpG/PapA_dom.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89A30 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNILLLDNI DSFTYNLVDQ LRSNFHQVFV YRNTVRKNII LKKLSKMINP
60 70 80 90 100
ILILSPGPGN PDNAGCMPQL LMELKGKLPI IGICLGHQAI VKMYGGHVGY
110 120 130 140 150
SGEILHGQAS LINHDNKAMF LGMSNPLPVA RYHSLICSNI PNMLVVNAHF
160 170 180 190
NNMVMAVRND YEKICGFQFH PESILTTRGT EFLQRVIQWT KI
Length:192
Mass (Da):21,603
Last modified:June 1, 2003 - v1
Checksum:iBBE006C1FC39B0BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO27227.1.
RefSeqiNP_778122.1. NC_004545.1.
WP_011091628.1. NC_004545.1.

Genome annotation databases

EnsemblBacteriaiAAO27227; AAO27227; bbp_525.
GeneIDi1058501.
KEGGibab:bbp525.
PATRICi21245873. VBIBucAph80364_0521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016826 Genomic DNA. Translation: AAO27227.1 .
RefSeqi NP_778122.1. NC_004545.1.
WP_011091628.1. NC_004545.1.

3D structure databases

ProteinModelPortali Q89A30.
SMRi Q89A30. Positions 2-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224915.bbp525.

Protein family/group databases

MEROPSi C26.960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO27227 ; AAO27227 ; bbp_525 .
GeneIDi 1058501.
KEGGi bab:bbp525.
PATRICi 21245873. VBIBucAph80364_0521.

Phylogenomic databases

eggNOGi COG0512.
KOi K01658.
OMAi ANPMPVA.
OrthoDBi EOG6M9F11.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00040 .
BioCyci BAPH224915:GJ9D-525-MONOMER.

Family and domain databases

Gene3Di 3.40.50.880. 1 hit.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR006221. TrpG/PapA_dom.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bp.

Entry informationi

Entry nameiTRPG_BUCBP
AccessioniPrimary (citable) accession number: Q89A30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3