Q89A30 (TRPG_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 2
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component II
Glutamine amido-transferase

Gene names

Name:	trpG
Ordered Locus Names:	bbp_525

Organism

Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]

Taxonomic identifier

224915 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Baizongia pistaciae)

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Anthranilate synthase component 2		PRO_0000056874
Regions
	Domain	3 – 192	190	Glutamine amidotransferase type-1
Sites
	Active site	84	1	By similarity
	Active site	170	1	By similarity
	Active site	172	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q89A30 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: BBE006C1FC39B0BC	FASTA	192	21,603
	10 20 30 40 50 60 MGNILLLDNI DSFTYNLVDQ LRSNFHQVFV YRNTVRKNII LKKLSKMINP ILILSPGPGN 70 80 90 100 110 120 PDNAGCMPQL LMELKGKLPI IGICLGHQAI VKMYGGHVGY SGEILHGQAS LINHDNKAMF 130 140 150 160 170 180 LGMSNPLPVA RYHSLICSNI PNMLVVNAHF NNMVMAVRND YEKICGFQFH PESILTTRGT 190 EFLQRVIQWT KI

References

[1]

"Reductive genome evolution in Buchnera aphidicola." van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A. Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016826 Genomic DNA. Translation: AAO27227.1.
RefSeq	NP_778122.1. NC_004545.1.
3D structure databases
ProteinModelPortal	Q89A30.
SMR	Q89A30. Positions 2-189.
ModBase	Search...
Protein-protein interaction databases
STRING	224915.bbp525.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO27227; AAO27227; bbp_525.
GeneID	1058501.
KEGG	bab:bbp525.
PATRIC	21245873. VBIBucAph80364_0521.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0512.
KO	K01658.
OMA	DNEAMFK.
Enzyme and pathway databases
BioCyc	BAPH224915:GJ9D-525-MONOMER.
UniPathway	UPA00035; UER00040.
Family and domain databases
InterPro	IPR017926. GATASE_1. IPR006221. TrpG/PapA. [Graphical view]
Pfam	PF00117. GATase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00566. trpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPG_BUCBP

Accession

Primary (citable) accession number: Q89A30

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program