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Q89A29 (TRPE_BUCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:bbp_526
OrganismBuchnera aphidicola subsp. Baizongia pistaciae (strain Bp) [Complete proteome] [HAMAP]
Taxonomic identifier224915 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Anthranilate synthase component 1
PRO_0000154082

Sequences

Sequence LengthMass (Da)Tools
Q89A29 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: FB2E344598D77315

FASTA52259,507
        10         20         30         40         50         60 
MKKNLISIDV FLTETRYQPN PTAIFNQICK KKSETLLLES AEINKKHHLE SMMIIDAALK 

        70         80         90        100        110        120 
ISFLNQIVIV EALTKNGVNL LSVFKSLLPK NVIILSDNNP LEIKFPILSM YLDEDQRLRS 

       130        140        150        160        170        180 
LSVFDAIRFL IKSVKNLSEF APKSMFFGGL FSYDLITSFE NLPILNTHQH CPDFCFYLSE 

       190        200        210        220        230        240 
TLLILDHKNK TSIVQVTSFT NDNFEKKRLK DRLEILKNKL SKNLCPIKFD TLKNMKLWCN 

       250        260        270        280        290        300 
KTDEEYNKII VNVKKFILQG EIFQVVPSRK FYLSCVNPLS SYEVLKKNNP SPYMFFMQDR 

       310        320        330        340        350        360 
KFTLFGASPE SALKYDINSR QIEIYPIAGT RPRGRRSDGS LDLDLDNRIE LEMRTNNKEL 

       370        380        390        400        410        420 
AEHLMLVDLA RNDLAKICEP GTRHVADLIR VDRYSHVMHL VSRVIGKLRF DLDFLHAYQA 

       430        440        450        460        470        480 
CMNMGTLTGA PKVRAMELIS EIEGEKRGSY GGAIGYFTGL GMLDTCIVIR SAYVENKIAT 

       490        500        510        520 
IQAGAGIVLD SVPQLESDES KNKAKAVIQA IANSHSCQIE YL

« Hide

References

[1]"Reductive genome evolution in Buchnera aphidicola."
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003) [PubMed: 12522265] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bp.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016826 Genomic DNA. Translation: AAO27228.1.
RefSeqNP_778123.1. NC_004545.1.

3D structure databases

ProteinModelPortalQ89A29.
SMRQ89A29. Positions 7-515.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000002354; EBBUCP00000002178; EBBUCG00000002354.
GeneID1058655.
GenomeReviewsGene locus bbp_526 in contig AE016826_GR.
KEGGbab:bbp526.
PATRIC21245875. VBIBucAph80364_0522.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008205.
HOGENOMHBG507440.
OMANDIARVC.
PhylomeDBQ89A29.
ProtClustDBPRK13564.

Enzyme and pathway databases

BioCycBAPH224915:BBP_526-MONOMER.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR005257. Anth_synth_I_TrpE.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KOK01657.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR00565. TrpE_proteo. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_BUCBP
AccessionPrimary (citable) accession number: Q89A29
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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