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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha

Gene

accD

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity).By similarity

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39ZincBy similarity1
Metal bindingi42ZincBy similarity1
Metal bindingi58ZincBy similarity1
Metal bindingi61ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 61C4-typeSequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha (EC:6.4.1.2)
Short name:
ACCase subunits beta/alpha
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha
Gene namesi
Name:accD
Synonyms:accA, accDA
Ordered Locus Names:CTC_00135
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001412 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591131 – 575Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alphaAdd BLAST575

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.By similarity

Protein-protein interaction databases

STRINGi212717.CTC00135.

Structurei

3D structure databases

ProteinModelPortaliQ899N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 301CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST267
Domaini295 – 548CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 264Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST264
Regioni35 – 548CarboxyltransferasePROSITE-ProRule annotationAdd BLAST514
Regioni265 – 571Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaAdd BLAST307

Sequence similaritiesi

In the N-terminal section; belongs to the AccD/PCCB family.Curated
In the C-terminal section; belongs to the AccA family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 61C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
COG0825. LUCA.
KOiK01962.
K01963.
OMAiAVIACEF.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
MF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00513. accA. 1 hit.
TIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q899N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRLFKKTK YITVSSHNLN EKDTTLEKPL IPDCMWSKCE KCGQIIYSKD
60 70 80 90 100
LRKNHSICGF CKNHFRISAY DRVKQIIDEG TWAEMDKNLC SVNPLNFKGY
110 120 130 140 150
NDKIEKAQEK TDLNEAVITG VGSIKGEKTV ICIMDSRFFM GSMGSVVGEK
160 170 180 190 200
ITRSIEKSIE NRLPLVIFTA SGGARMQEGM FSLMQMAKIS AALSKLSQAG
210 220 230 240 250
LLYITVLTDP TTGGVTASFA MLGDIILSEP GALIGFAGKR VIEQTINKKL
260 270 280 290 300
PKGFQTAEFL MKHGFIDKIV NRKNLKDTLS MILKLHREKC EFKSYKDITV
310 320 330 340 350
NKVNTLKNKL DAWGKLSMAR NEKRPTSLDY IDNIFENFME FHGDRYYGND
360 370 380 390 400
SCIVGGIGIL DGVPVTIIAQ QKGRDLNENI ERNFGMPNPE GYRKALRLMK
410 420 430 440 450
QAEKFNRPIV CFIDTPGAYC GVEAEQRGQG EAIAKNLINM ISLEVPIISI
460 470 480 490 500
VIGEGGSGGA LALSVSDKIW MLENAVYSLL SPEGFASILW RDSTKAKEAA
510 520 530 540 550
NIMKITSEDL KSYSLIDKIL YEPDRDASKN VKVMSNIIKN NLIKEFNNLM
560 570
DLDRDELLNK RYNKFRVIGE YKNKT
Length:575
Mass (Da):64,630
Last modified:June 1, 2003 - v1
Checksum:i2B90933F7C0DE945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA. Translation: AAO34787.1.
RefSeqiWP_011098459.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO34787; AAO34787; CTC_00135.
GeneIDi24253928.
KEGGictc:CTC_00135.

Similar proteinsi

Entry informationi

Entry nameiACCDA_CLOTE
AccessioniPrimary (citable) accession number: Q899N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families