Reviewed,
UniProtKB/Swiss-Prot Q899I8 (KPRS_CLOTE)
Last modified
February 9, 2010.
Version 49.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribose-phosphate pyrophosphokinase Short name=RPPK EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthetase Short name=P-Rib-PP synthetase Short name=PRPP synthetase | ||||
| Gene names |
| ||||
| Organism | Clostridium tetani [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1513 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium |
Protein attributes
| Sequence length | 320 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583 |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583 |
| Pathway | Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00583. |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activityInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: HAMAP ribose phosphate diphosphokinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 320 | 320 | Ribose-phosphate pyrophosphokinase HAMAP MF_00583 | PRO_0000141128 | |||||
Regions | |||||||||
| Region | 220 – 233 | 14 | Binding of phosphoribosylpyrophosphate Potential | ||||||
Sites | |||||||||
| Metal binding | 134 | 1 | Magnesium Potential | ||||||
| Metal binding | 136 | 1 | Magnesium Potential | ||||||
| Metal binding | 145 | 1 | Magnesium Potential | ||||||
| Metal binding | 149 | 1 | Magnesium Potential | ||||||
Sequences
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References
| [1] | "The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE015927 Genomic DNA. Translation: AAO34838.1. |
| RefSeq | NP_780901.1. |
3D structure databases | |
| SMR | Q899I8. Positions 8-319. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1059268. |
| GenomeReviews | Gene locus CTC_00188 in contig AE015927_GR. |
| KEGG | ctc:CTC00188. |
| NMPDR | fig|212717.1.peg.123. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG519284. |
| OMA | CATHAVF. |
| PhylomeDB | Q899I8. |
Enzyme and pathway databases | |
| BioCyc | CTET212717:CTC_00188-MONOMER. |
| BRENDA | 2.7.6.1. 2082. |
Family and domain databases | |
| HAMAP | MF_00583_B. RibP_PPkinase_B. [Tree] |
| InterPro | IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01251. ribP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KPRS_CLOTE | ||||||||
| Accession | Primary (citable) accession number: Q899I8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


