Q89940 (TYSY_EHV2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45

Gene names

ORF Names:

70

Organism

Equine herpesvirus 2 (strain 86/87) (EHV-2) [Reference proteome]

Taxonomic identifier

82831 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Percavirus › Equid herpesvirus 2

Virus host

Equus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Thymidylate synthase		PRO_0000141062
Sites
	Active site	171	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q89940 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E0B18D51A1AB1A54	FASTA	289	32,575
	10 20 30 40 50 60 MVTHCEHQYL NTVREILANG VRRGDRTGVG TLSVFGDQAK YSLRGQFPLL TTKRVFWRGV 70 80 90 100 110 120 LEELLWFIRG STDSNELSAR GVKIWDANGS RDFLARAGLG HREPGDLGPV YGFQWRHFGA 130 140 150 160 170 180 AYVDSKTDYR GQGVDQLRDL IGEIKRNPES RRLVLTAWNP ADLPAMALPP CHLLCQFYVA 190 200 210 220 230 240 GGELSCQLYQ RSGDMGLGVP FNIASYSLLT YMVAHLTGLE PGDFIHVLGD AHVYLNHVEP 250 260 270 280 LKLQLTRSPR PFPRLRILRR VEDIDDFRAE DFALEGYHPH AAIPMEMAV

References

[1]	"The DNA sequence of equine herpesvirus 2." Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J. J. Mol. Biol. 249:520-528(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20824 Genomic DNA. Translation: AAC13860.1.
PIR	S55667.
RefSeq	NP_042669.1. NC_001650.1.
3D structure databases
ProteinModelPortal	Q89940.
SMR	Q89940. Positions 4-289.
ModBase	Search...
Proteomic databases
PRIDE	Q89940.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1461029.
Phylogenomic databases
ProtClustDB	CLSP2509595.
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
Gene3D	3.30.572.10. 1 hit.
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. IPR020940. Thymidylate_synthase_AS. [Graphical view]
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_EHV2

Accession

Primary (citable) accession number: Q89940

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program