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Q89940 (TYSY_EHV2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
ORF Names:70
OrganismEquine herpesvirus 2 (strain 86/87) (EHV-2) [Reference proteome]
Taxonomic identifier82831 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000141062

Sites

Active site1711 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q89940 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E0B18D51A1AB1A54

FASTA28932,575
        10         20         30         40         50         60 
MVTHCEHQYL NTVREILANG VRRGDRTGVG TLSVFGDQAK YSLRGQFPLL TTKRVFWRGV 

        70         80         90        100        110        120 
LEELLWFIRG STDSNELSAR GVKIWDANGS RDFLARAGLG HREPGDLGPV YGFQWRHFGA 

       130        140        150        160        170        180 
AYVDSKTDYR GQGVDQLRDL IGEIKRNPES RRLVLTAWNP ADLPAMALPP CHLLCQFYVA 

       190        200        210        220        230        240 
GGELSCQLYQ RSGDMGLGVP FNIASYSLLT YMVAHLTGLE PGDFIHVLGD AHVYLNHVEP 

       250        260        270        280 
LKLQLTRSPR PFPRLRILRR VEDIDDFRAE DFALEGYHPH AAIPMEMAV 

« Hide

References

[1]"The DNA sequence of equine herpesvirus 2."
Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.
J. Mol. Biol. 249:520-528(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20824 Genomic DNA. Translation: AAC13860.1.
PIRS55667.
RefSeqNP_042669.1. NC_001650.1.

3D structure databases

ProteinModelPortalQ89940.
SMRQ89940. Positions 4-289.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ89940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1461029.

Phylogenomic databases

ProtClustDBCLSP2509595.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_EHV2
AccessionPrimary (citable) accession number: Q89940
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways