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Reviewed, UniProtKB/Swiss-Prot Q898X3 (MURA2_CLOTE)

Last modified November 3, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 2
    UDP-N-acetylglucosamine enolpyruvyl transferase 2
      Short name=EPT 2
Gene names
Name: murA2
Ordered Locus Names: CTC_00314
OrganismClostridium tetani [Complete proteome] [HAMAP]
Taxonomic identifier1513 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 HAMAP MF_00111
PRO_0000231191

Sites

Active site1181Proton donor By similarity
Binding site1181Phosphoenolpyruvate (covalent) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q898X3-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 0F13EE4BA3F3C9D1

FASTA41744,777
        10         20         30         40         50         60 
MNKIIVNGGK SLKGEVNINS AKNSVLPIIA ASILSGDKCI IENAPMLEDV FVISEVLKSI 

        70         80         90        100        110        120 
SSEVDIDRDN NKIIIDTSNI CNSEPCSELV KKLRASFLIM GPMISRFGNF KISLPGGCNI 

       130        140        150        160        170        180 
GTRPIDLHLK GLNALGADIN IGYGYVEAKA DKLKGNKIYL DFPSVGATEN LMMAAVLAEG 

       190        200        210        220        230        240 
DTIIQNAAEE PEIEDLAKFL NSMGANIVGA GTDTINIIGV KDLKGVVHKP IYDRIEAGTF 

       250        260        270        280        290        300 
MTAAAITRSK IKLNGVNEGH LRPIIAKLTE IGVKIDTNGD SMIVDGNHQL KPVDIKTMPY 

       310        320        330        340        350        360 
PGFPTDMQAQ TMALLTSIEG TSIVTETIFE NRFMHATEMK RMGSNIKIDG RSAVIEGGNE 

       370        380        390        400        410 
LTGCEVKATD LRAGAALILC GLVARGSTNV TDVYHIDRGY ANIEKKLQAL GAEIYRI 

« Hide

References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

AE015927 Genomic DNA. Translation: AAO34956.1.
RefSeqNP_781019.1.

3D structure databases

HSSPHSSP built from PDB template 1DLG based on UniProtKB P33038.
ModBaseSearch...

Genome annotation databases

GeneID1059891.
GenomeReviewsGene locus CTC_00314 in contig AE015927_GR.
KEGGctc:CTC00314.
NMPDRfig|212717.1.peg.241.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ898X3.
OMAVSRVYHL.

Enzyme and pathway databases

BioCycCTET212717:CTC_00314-MON.
BRENDA2.5.1.7. 2082.

Family and domain databases

HAMAPMF_00111.
[Tree]
InterProIPR001986. EPSP_synthase_core.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PANTHERPTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
ProDomPD001867. EPSP_synth. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA2_CLOTE
AccessionPrimary (citable) accession number: Q898X3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2003
Last modified: November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents