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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei575ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTET212717:G1G04-336-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CTC_00337
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001412 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520041 – 812Leucine--tRNA ligaseAdd BLAST812

Proteomic databases

PRIDEiQ898V2

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC00337

Structurei

3D structure databases

ProteinModelPortaliQ898V2
SMRiQ898V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi572 – 576"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q898V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNYGTNIDR KWQNKWEDSN LYHFDTNNLD KKLYVLEMFS YPSGSNLHAG
60 70 80 90 100
HWFNYGPSDS WARFKRMQGF NVFQPMGFDS FGLPAENYAI KTGVHPKDST
110 120 130 140 150
MKNIETMTKQ LKSMGAMFHW DNEVITSEPE YYKWTQWMFL QLYKNNLAYR
160 170 180 190 200
KNAPVNWCPS CNTVLANEQV LDGACERCSS DVIKKDLTQW FFKITDYAEE
210 220 230 240 250
LLEKLDDLDW PENTKSMQKH WIGKSIGAQL TFKIVDSDLS FDIFTTRADT
260 270 280 290 300
LFGVTYAVLA PENPLVDKIT KEDHKAEIEA YKEQAKKQSE IERQSITREK
310 320 330 340 350
TGVFTGSYAI NPINGKKVPV WVGDYVLSTY GTGAVMAVPA HDERDFEFAK
360 370 380 390 400
KHNLPIEKVI EGGETLPYTE DGIMINSEEF NGLESSKGRS AVVEKLEKEN
410 420 430 440 450
LGVKKINYRL RDWLVSRQRY WGAPIPIVYC DKCGTVAVPE EQLPVKLPYD
460 470 480 490 500
VEFTPDGKSP LSKCDSFVNT TCPTCGGPAK REVDTLDTFV CSSWYFLRYA
510 520 530 540 550
DNKNSEKAFD PKIINEILPV DKYVGGPEHA CMHLLYARFF TKALRDMGYL
560 570 580 590 600
NFDEPFSSLT HQGLILGPDG LKMSKSKGNT ISPDDYIDEF GSDVFRMYLM
610 620 630 640 650
FGFDYTEGGA WSDEGIKSVS RFVDRVERTL ASCRYYINNP SDDKITIDNN
660 670 680 690 700
EKDLNFVRHN SIKSITEDAE KMQFNTCIAR LMEYTNALSK YINEDNKNSK
710 720 730 740 750
FLKECVEDFI ILIAPFAPHF SEEQWELLGM TYSVFNEKWP QFDSKALVKD
760 770 780 790 800
EIEIAVQVNG KIRDRITIAS GLDEESIKET ALNSEDVKKY TDGKNIVKII
810
IIKGRLVNIV VK
Length:812
Mass (Da):93,037
Last modified:June 20, 2003 - v1
Checksum:i230DDDDC5F31CB2D
GO

Sequence cautioni

The sequence AAO34977 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA Translation: AAO34977.1 Different initiation.
RefSeqiWP_035110983.1, NC_004557.1

Genome annotation databases

EnsemblBacteriaiAAO34977; AAO34977; CTC_00337
GeneIDi24254654
KEGGictc:CTC_00337

Similar proteinsi

Entry informationi

Entry nameiSYL_CLOTE
AccessioniPrimary (citable) accession number: Q898V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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