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Q898V2

- SYL_CLOTE

UniProt

Q898V2 - SYL_CLOTE

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Protein
Leucine--tRNA ligase
Gene
leuS, CTC_00337
Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei575 – 5751ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTET212717:GJAM-296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CTC_00337
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Leucine--tRNA ligaseUniRule annotation
PRO_0000152004Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC00337.

Structurei

3D structure databases

ProteinModelPortaliQ898V2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi572 – 5765"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q898V2-1 [UniParc]FASTAAdd to Basket

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MGNYGTNIDR KWQNKWEDSN LYHFDTNNLD KKLYVLEMFS YPSGSNLHAG    50
HWFNYGPSDS WARFKRMQGF NVFQPMGFDS FGLPAENYAI KTGVHPKDST 100
MKNIETMTKQ LKSMGAMFHW DNEVITSEPE YYKWTQWMFL QLYKNNLAYR 150
KNAPVNWCPS CNTVLANEQV LDGACERCSS DVIKKDLTQW FFKITDYAEE 200
LLEKLDDLDW PENTKSMQKH WIGKSIGAQL TFKIVDSDLS FDIFTTRADT 250
LFGVTYAVLA PENPLVDKIT KEDHKAEIEA YKEQAKKQSE IERQSITREK 300
TGVFTGSYAI NPINGKKVPV WVGDYVLSTY GTGAVMAVPA HDERDFEFAK 350
KHNLPIEKVI EGGETLPYTE DGIMINSEEF NGLESSKGRS AVVEKLEKEN 400
LGVKKINYRL RDWLVSRQRY WGAPIPIVYC DKCGTVAVPE EQLPVKLPYD 450
VEFTPDGKSP LSKCDSFVNT TCPTCGGPAK REVDTLDTFV CSSWYFLRYA 500
DNKNSEKAFD PKIINEILPV DKYVGGPEHA CMHLLYARFF TKALRDMGYL 550
NFDEPFSSLT HQGLILGPDG LKMSKSKGNT ISPDDYIDEF GSDVFRMYLM 600
FGFDYTEGGA WSDEGIKSVS RFVDRVERTL ASCRYYINNP SDDKITIDNN 650
EKDLNFVRHN SIKSITEDAE KMQFNTCIAR LMEYTNALSK YINEDNKNSK 700
FLKECVEDFI ILIAPFAPHF SEEQWELLGM TYSVFNEKWP QFDSKALVKD 750
EIEIAVQVNG KIRDRITIAS GLDEESIKET ALNSEDVKKY TDGKNIVKII 800
IIKGRLVNIV VK 812
Length:812
Mass (Da):93,037
Last modified:June 20, 2003 - v1
Checksum:i230DDDDC5F31CB2D
GO

Sequence cautioni

The sequence AAO34977.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO34977.1. Different initiation.
RefSeqiNP_781040.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO34977; AAO34977; CTC_00337.
GeneIDi1059914.
KEGGictc:CTC00337.
PATRICi19508494. VBICloTet101274_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO34977.1 . Different initiation.
RefSeqi NP_781040.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q898V2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212717.CTC00337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO34977 ; AAO34977 ; CTC_00337 .
GeneIDi 1059914.
KEGGi ctc:CTC00337.
PATRICi 19508494. VBICloTet101274_0304.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CTET212717:GJAM-296-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiSYL_CLOTE
AccessioniPrimary (citable) accession number: Q898V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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