Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q898V2

- SYL_CLOTE

UniProt

Q898V2 - SYL_CLOTE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei575 – 5751ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTET212717:GJAM-296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CTC_00337
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Leucine--tRNA ligasePRO_0000152004Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC00337.

Structurei

3D structure databases

ProteinModelPortaliQ898V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi572 – 5765"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q898V2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNYGTNIDR KWQNKWEDSN LYHFDTNNLD KKLYVLEMFS YPSGSNLHAG
60 70 80 90 100
HWFNYGPSDS WARFKRMQGF NVFQPMGFDS FGLPAENYAI KTGVHPKDST
110 120 130 140 150
MKNIETMTKQ LKSMGAMFHW DNEVITSEPE YYKWTQWMFL QLYKNNLAYR
160 170 180 190 200
KNAPVNWCPS CNTVLANEQV LDGACERCSS DVIKKDLTQW FFKITDYAEE
210 220 230 240 250
LLEKLDDLDW PENTKSMQKH WIGKSIGAQL TFKIVDSDLS FDIFTTRADT
260 270 280 290 300
LFGVTYAVLA PENPLVDKIT KEDHKAEIEA YKEQAKKQSE IERQSITREK
310 320 330 340 350
TGVFTGSYAI NPINGKKVPV WVGDYVLSTY GTGAVMAVPA HDERDFEFAK
360 370 380 390 400
KHNLPIEKVI EGGETLPYTE DGIMINSEEF NGLESSKGRS AVVEKLEKEN
410 420 430 440 450
LGVKKINYRL RDWLVSRQRY WGAPIPIVYC DKCGTVAVPE EQLPVKLPYD
460 470 480 490 500
VEFTPDGKSP LSKCDSFVNT TCPTCGGPAK REVDTLDTFV CSSWYFLRYA
510 520 530 540 550
DNKNSEKAFD PKIINEILPV DKYVGGPEHA CMHLLYARFF TKALRDMGYL
560 570 580 590 600
NFDEPFSSLT HQGLILGPDG LKMSKSKGNT ISPDDYIDEF GSDVFRMYLM
610 620 630 640 650
FGFDYTEGGA WSDEGIKSVS RFVDRVERTL ASCRYYINNP SDDKITIDNN
660 670 680 690 700
EKDLNFVRHN SIKSITEDAE KMQFNTCIAR LMEYTNALSK YINEDNKNSK
710 720 730 740 750
FLKECVEDFI ILIAPFAPHF SEEQWELLGM TYSVFNEKWP QFDSKALVKD
760 770 780 790 800
EIEIAVQVNG KIRDRITIAS GLDEESIKET ALNSEDVKKY TDGKNIVKII
810
IIKGRLVNIV VK
Length:812
Mass (Da):93,037
Last modified:June 20, 2003 - v1
Checksum:i230DDDDC5F31CB2D
GO

Sequence cautioni

The sequence AAO34977.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO34977.1. Different initiation.
RefSeqiNP_781040.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO34977; AAO34977; CTC_00337.
GeneIDi1059914.
KEGGictc:CTC00337.
PATRICi19508494. VBICloTet101274_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO34977.1 . Different initiation.
RefSeqi NP_781040.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q898V2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212717.CTC00337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO34977 ; AAO34977 ; CTC_00337 .
GeneIDi 1059914.
KEGGi ctc:CTC00337.
PATRICi 19508494. VBICloTet101274_0304.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CTET212717:GJAM-296-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiSYL_CLOTE
AccessioniPrimary (citable) accession number: Q898V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3