Q898T6 (Q898T6_CLOTE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
NAD-dependent malic enzyme EMBL AAO34993.1
EC=1.1.1.38 EMBL AAO34993.1

Gene names

Ordered Locus Names:

CTC_00356 EMBL AAO34993.1

Organism

Clostridium tetani (strain Massachusetts / E88) [Complete proteome] [HAMAP] EMBL AAO34993.1

Taxonomic identifier

212717 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium tetani

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Divalent metal cations. Prefers magnesium or manganese By similarity. PIRSR PIRSR000106-3
Sequence similarities	Belongs to the malic enzymes family. RuleBase RU003427

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003427 PIRSR PIRSR000106-3
Molecular function	Oxidoreductase RuleBase RU003427 EMBL AAO34993.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	malate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro malate dehydrogenase (oxaloacetate-decarboxylating) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	36	1	Proton donor By similarity PIRSR PIRSR000106-1
	Active site	91	1	Proton acceptor By similarity PIRSR PIRSR000106-1
	Metal binding	133	1	Divalent metal cation By similarity PIRSR PIRSR000106-3
	Metal binding	134	1	Divalent metal cation By similarity PIRSR PIRSR000106-3
	Metal binding	159	1	Divalent metal cation By similarity PIRSR PIRSR000106-3

Sequences

	Sequence		Length	Mass (Da)
	Q898T6 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B89ECC08D413B72D	FASTA	389	42,268
	10 20 30 40 50 60 MDVKEMALKL HSEKKGKLEV VGKISVKNRE DLALAYTPGV AEPCVHISKD KNKVYEYTTK 70 80 90 100 110 120 GNMVAVVTNG TAVLGLGNIG PEAALPVMEG KALLFKEFAN VDAFPICLDT EDPEEIIRTV 130 140 150 160 170 180 KLMAPGFGGI NLEDIKAPEC FYIEERLKKE LDIPVFHDDQ HGTAIVVLAG IYNALKIVDK 190 200 210 220 230 240 KLEEAKILIN GAGSAGIAIC KLLLNAGACN IVMCDINGSL VEGDENLNPA QKEIAKVTNK 250 260 270 280 290 300 EKEKGKLVDV IKDKDIFIGV SGPKILTKEM VSTMAKDSIV FAMANPEPEI LPDEAKAGGA 310 320 330 340 350 360 RVVATGRSDF PNQINNVLVF PGIFRGALDV KAREINEEMK IAAARGVANL IKEEDLNEEY 370 380 IIPDPFNKEV AESVSKEVRR IAKEMNICK

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015927 Genomic DNA. Translation: AAO34993.1.
RefSeq	NP_781056.1. NC_004557.1.
3D structure databases
ProteinModelPortal	Q898T6.
SMR	Q898T6. Positions 2-382.
ModBase	Search...
Protein-protein interaction databases
STRING	212717.CTC00356.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO34993; AAO34993; CTC_00356.
GeneID	1059931.
KEGG	ctc:CTC00356.
PATRIC	19508534. VBICloTet101274_0323.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00027.
OMA	VKAREIN.
ProtClustDB	CLSK911955.
Enzyme and pathway databases
BioCyc	CTET212717:GJAM-313-MONOMER.
Family and domain databases
Gene3D	3.40.50.10380. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR015884. Malic_enzyme_CS. IPR012301. Malic_N. IPR012302. Malic_NAD-bd. IPR001891. Malic_OxRdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00390. malic. 1 hit. PF03949. Malic_M. 1 hit. [Graphical view]
PIRSF	PIRSF000106. ME. 1 hit.
PRINTS	PR00072. MALOXRDTASE.
SMART	SM00919. Malic_M. 1 hit. [Graphical view]
PROSITE	PS00331. MALIC_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q898T6_CLOTE

Accession

Primary (citable) accession number: Q898T6

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)