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Q898Q9 (HPPA_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative K(+)-stimulated pyrophosphate-energized sodium pump
EC=3.6.1.1
Alternative name(s):
Membrane-bound sodium-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Short name=Na(+)-PPase
Gene names
Name:hppA
Ordered Locus Names:CTC_00383
OrganismClostridium tetani [Complete proteome] [HAMAP]
Taxonomic identifier1513 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length673 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane By similarity. HAMAP MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_01129

Cofactor

Magnesium By similarity. HAMAP MF_01129

Enzyme regulation

Requires K+ for maximal activity By similarity. HAMAP MF_01129

Subunit structure

Homodimer By similarity. HAMAP MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 673673Putative K(+)-stimulated pyrophosphate-energized sodium pump HAMAP MF_01129
PRO_0000217002

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane302 – 32221Helical; Potential
Transmembrane364 – 38421Helical; Potential
Transmembrane387 – 40721Helical; Potential
Transmembrane449 – 46921Helical; Potential
Transmembrane486 – 50621Helical; Potential
Transmembrane553 – 57321Helical; Potential
Transmembrane576 – 59621Helical; Potential
Transmembrane652 – 67221Helical; Potential

Sites

Site4491Determinant of potassium dependence By similarity

Sequences

Sequence LengthMass (Da)Tools
Q898Q9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E3505682EE10FF56

FASTA67369,282
        10         20         30         40         50         60 
MESFIVYSVL AGVIALIFAF MLSSFISKES AGNERMQEIA GHIHDGAMAF LKTEYKYLTG 

        70         80         90        100        110        120 
FIVIVTVILA IFVGWQTAAC FILGAIFSIF AGYFGMNVAT KANVRTAEAA RHSQGKALNI 

       130        140        150        160        170        180 
AFSGGAVMGM SVVGLGVVGI GIMYYIFGGN MEFVTGFGLG ASSIALFARV GGGIYTKAAD 

       190        200        210        220        230        240 
VGADLVGKVE AGIPEDDPRN PAVIADNVGD NVGDVAGMGA DLFESYVGSI ISALTLGTVV 

       250        260        270        280        290        300 
YANKEGVMFP LILSSIGIVA SIIGILFSRK SKAKDPQKAL NTGTYIGGII VIVSAAILSN 

       310        320        330        340        350        360 
TIFGNLKAFF AVASGLVVGM IIGKITEMYT SDAYSSVQKI ANQSETGPAT TIISGLAVGM 

       370        380        390        400        410        420 
YSTLWPIVLI SIGVLVSFFV MGGGSNAMVG LYGISLAAVG MLSTTGLTVA VDAYGPIADN 

       430        440        450        460        470        480 
AGGIAEMSEL PHEVREITDK LDSVGNTTAA IGKGFAIGSA ALTALSLFAS YAQATELESI 

       490        500        510        520        530        540 
DILNTVTLVG LFIGAMLPFL FGALTMESVG KAANEMIEEV RRQFKTIPGI MEGKATPDYK 

       550        560        570        580        590        600 
KCVDISTAAA IREMILPGVL AIVVPVAMGL LLGKEALGGL LAGALVSGVL VGILMSNAGG 

       610        620        630        640        650        660 
AWDNAKKYIE GGAHGGKGSE AHKAAVVGDT VGDPFKDTSG PSMNILIKLM TIVSLVFAPV 

       670 
VLQYGGILLN LIK

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References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015927 Genomic DNA. Translation: AAO35020.1.
RefSeqNP_781083.1. NC_004557.1.

3D structure databases

ProteinModelPortalQ898Q9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1059962.
GenomeReviewsGene locus CTC_00383 in contig AE015927_GR.
KEGGctc:CTC00383.
NMPDRfig|212717.1.peg.305.
PATRIC19508592. VBICloTet101274_0352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG593668.
OMAIAEMSGL.
PhylomeDBQ898Q9.
ProtClustDBPRK00733.

Enzyme and pathway databases

BioCycCTET212717:CTC_00383-MONOMER.

Family and domain databases

HAMAPMF_01129. PPase-energized_pump.
[Tree]
InterProIPR004131. PPase-energised_H-pump.
[Graphical view]
KOK01507.
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
TIGRFAMsTIGR01104. V_PPase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPA_CLOTE
AccessionPrimary (citable) accession number: Q898Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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