Q898Q9 (HPPA_CLOTE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Putative K(+)-stimulated pyrophosphate-energized sodium pump EC=3.6.1.1 Alternative name(s): Membrane-bound sodium-translocating pyrophosphatase Pyrophosphate-energized inorganic pyrophosphatase Short name=Na(+)-PPase | ||||
| Gene names |
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| Organism | Clostridium tetani [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1513 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium |
Protein attributes
| Sequence length | 673 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane By similarity. HAMAP MF_01129 |
| Catalytic activity | Diphosphate + H2O = 2 phosphate. HAMAP MF_01129 |
| Cofactor | Magnesium By similarity. HAMAP MF_01129 |
| Enzyme regulation | Requires K+ for maximal activity By similarity. HAMAP MF_01129 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01129 |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129. |
| Sequence similarities | Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Sodium transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Ligand | Magnesium Potassium Sodium |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proton transport Inferred from electronic annotation. Source: InterPro sodium ion transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | hydrogen-translocating pyrophosphatase activity Inferred from electronic annotation. Source: InterPro inorganic diphosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 673 | 673 | Putative K(+)-stimulated pyrophosphate-energized sodium pump HAMAP MF_01129 | PRO_0000217002 | |||||
Regions | |||||||||
| Transmembrane | 3 – 23 | 21 | Helical; Potential | ||||||
| Transmembrane | 62 – 82 | 21 | Helical; Potential | ||||||
| Transmembrane | 84 – 104 | 21 | Helical; Potential | ||||||
| Transmembrane | 127 – 147 | 21 | Helical; Potential | ||||||
| Transmembrane | 154 – 174 | 21 | Helical; Potential | ||||||
| Transmembrane | 222 – 242 | 21 | Helical; Potential | ||||||
| Transmembrane | 247 – 267 | 21 | Helical; Potential | ||||||
| Transmembrane | 279 – 299 | 21 | Helical; Potential | ||||||
| Transmembrane | 302 – 322 | 21 | Helical; Potential | ||||||
| Transmembrane | 364 – 384 | 21 | Helical; Potential | ||||||
| Transmembrane | 387 – 407 | 21 | Helical; Potential | ||||||
| Transmembrane | 449 – 469 | 21 | Helical; Potential | ||||||
| Transmembrane | 486 – 506 | 21 | Helical; Potential | ||||||
| Transmembrane | 553 – 573 | 21 | Helical; Potential | ||||||
| Transmembrane | 576 – 596 | 21 | Helical; Potential | ||||||
| Transmembrane | 652 – 672 | 21 | Helical; Potential | ||||||
Sites | |||||||||
| Site | 449 | 1 | Determinant of potassium dependence By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE015927 Genomic DNA. Translation: AAO35020.1. |
| RefSeq | NP_781083.1. NC_004557.1. |
3D structure databases | |
| ProteinModelPortal | Q898Q9. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1059962. |
| GenomeReviews | Gene locus CTC_00383 in contig AE015927_GR. |
| KEGG | ctc:CTC00383. |
| NMPDR | fig|212717.1.peg.305. |
| PATRIC | 19508592. VBICloTet101274_0352. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG593668. |
| OMA | IAEMSGL. |
| PhylomeDB | Q898Q9. |
| ProtClustDB | PRK00733. |
Enzyme and pathway databases | |
| BioCyc | CTET212717:CTC_00383-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01129. PPase-energized_pump. [Tree] |
| InterPro | IPR004131. PPase-energised_H-pump. [Graphical view] |
| KO | K01507. |
| Pfam | PF03030. H_PPase. 1 hit. [Graphical view] |
| PIRSF | PIRSF001265. H+-PPase. 1 hit. |
| TIGRFAMs | TIGR01104. V_PPase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HPPA_CLOTE | ||||||||
| Accession | Primary (citable) accession number: Q898Q9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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