Q898B8 (UPPP_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	CTC_00545

Organism

Clostridium tetani (strain Massachusetts / E88) [Complete proteome] [HAMAP]

Taxonomic identifier

212717 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium tetani

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151137
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Transmembrane	149 – 168	20	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Transmembrane	214 – 234	21	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q898B8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 51DC4D615A70A006	FASTA	271	30,113
	10 20 30 40 50 60 MLLILKAIIL AIVEGLTEFV PVSSTGHLIL VSDVINFKGD YANLFNVVIQ LGAILAVVVV 70 80 90 100 110 120 YWDKLLNSVK DIFAPDRRGL RFWINIVVAC IPAVIFGFSL DDYIDKYLFN PITVAIGLVI 130 140 150 160 170 180 GGILMIIVEN KYRRRSKTKN IYDMKLRQSI FVGMFQCLAL WPGMSRSAST IMGGWIAGLS 190 200 210 220 230 240 PVVAAEFSFF LAIPVMVGAS GLKLVKSGFY MTNIEFIALI VGFVGAFLVS LVVIEKFIKF 250 260 270 LQKKPMRIFA IYRIFIGAIL LILAIFKIVT I

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015927 Genomic DNA. Translation: AAO35165.1.
RefSeq	NP_781228.1. NC_004557.1.
3D structure databases
ProteinModelPortal	Q898B8.
ModBase	Search...
Protein-protein interaction databases
STRING	212717.CTC00545.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO35165; AAO35165; CTC_00545.
GeneID	1060197.
KEGG	ctc:CTC00545.
PATRIC	19508910. VBICloTet101274_0511.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
KO	K06153.
OMA	WEFRARI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	CTET212717:GJAM-485-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_CLOTE

Accession

Primary (citable) accession number: Q898B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program