SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q898B8

- UPPP_CLOTE

UniProt

Q898B8 - UPPP_CLOTE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Undecaprenyl-diphosphatase

Gene
uppP, bacA, upk, CTC_00545
Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCTET212717:GJAM-485-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:CTC_00545
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed predictionAdd
BLAST
Transmembranei42 – 6221Helical; Reviewed predictionAdd
BLAST
Transmembranei80 – 10021Helical; Reviewed predictionAdd
BLAST
Transmembranei108 – 12821Helical; Reviewed predictionAdd
BLAST
Transmembranei149 – 16820Helical; Reviewed predictionAdd
BLAST
Transmembranei175 – 19521Helical; Reviewed predictionAdd
BLAST
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Transmembranei248 – 26821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Undecaprenyl-diphosphataseUniRule annotationPRO_0000151137Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC00545.

Structurei

3D structure databases

ProteinModelPortaliQ898B8.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiYRIFIGA.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q898B8-1 [UniParc]FASTAAdd to Basket

« Hide

MLLILKAIIL AIVEGLTEFV PVSSTGHLIL VSDVINFKGD YANLFNVVIQ    50
LGAILAVVVV YWDKLLNSVK DIFAPDRRGL RFWINIVVAC IPAVIFGFSL 100
DDYIDKYLFN PITVAIGLVI GGILMIIVEN KYRRRSKTKN IYDMKLRQSI 150
FVGMFQCLAL WPGMSRSAST IMGGWIAGLS PVVAAEFSFF LAIPVMVGAS 200
GLKLVKSGFY MTNIEFIALI VGFVGAFLVS LVVIEKFIKF LQKKPMRIFA 250
IYRIFIGAIL LILAIFKIVT I 271
Length:271
Mass (Da):30,113
Last modified:June 1, 2003 - v1
Checksum:i51DC4D615A70A006
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO35165.1.
RefSeqiNP_781228.1. NC_004557.1.
WP_011098832.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO35165; AAO35165; CTC_00545.
GeneIDi1060197.
KEGGictc:CTC00545.
PATRICi19508910. VBICloTet101274_0511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO35165.1 .
RefSeqi NP_781228.1. NC_004557.1.
WP_011098832.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q898B8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212717.CTC00545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO35165 ; AAO35165 ; CTC_00545 .
GeneIDi 1060197.
KEGGi ctc:CTC00545.
PATRICi 19508910. VBICloTet101274_0511.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi YRIFIGA.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CTET212717:GJAM-485-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiUPPP_CLOTE
AccessioniPrimary (citable) accession number: Q898B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi