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Q898B8 (UPPP_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:CTC_00545
OrganismClostridium tetani (strain Massachusetts / E88) [Complete proteome] [HAMAP]
Taxonomic identifier212717 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151137

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane149 – 16820Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane248 – 26821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q898B8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 51DC4D615A70A006

FASTA27130,113
        10         20         30         40         50         60 
MLLILKAIIL AIVEGLTEFV PVSSTGHLIL VSDVINFKGD YANLFNVVIQ LGAILAVVVV 

        70         80         90        100        110        120 
YWDKLLNSVK DIFAPDRRGL RFWINIVVAC IPAVIFGFSL DDYIDKYLFN PITVAIGLVI 

       130        140        150        160        170        180 
GGILMIIVEN KYRRRSKTKN IYDMKLRQSI FVGMFQCLAL WPGMSRSAST IMGGWIAGLS 

       190        200        210        220        230        240 
PVVAAEFSFF LAIPVMVGAS GLKLVKSGFY MTNIEFIALI VGFVGAFLVS LVVIEKFIKF 

       250        260        270 
LQKKPMRIFA IYRIFIGAIL LILAIFKIVT I 

« Hide

References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015927 Genomic DNA. Translation: AAO35165.1.
RefSeqNP_781228.1. NC_004557.1.

3D structure databases

ProteinModelPortalQ898B8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING212717.CTC00545.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO35165; AAO35165; CTC_00545.
GeneID1060197.
KEGGctc:CTC00545.
PATRIC19508910. VBICloTet101274_0511.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAMGASKRS.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycCTET212717:GJAM-485-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CLOTE
AccessionPrimary (citable) accession number: Q898B8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families