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Q89865

- VP7_ROTHC

UniProt

Q89865 - VP7_ROTHC

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Protein

Outer capsid glycoprotein VP7

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors (By similarity).By similarity

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid glycoprotein VP7
OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Taxonomic identifieri31567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007664: Genome

Subcellular locationi

Virion By similarity. Host endoplasmic reticulum lumen Curated
Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles (By similarity).By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. T=13 icosahedral viral capsid Source: UniProtKB-KW
  3. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host endoplasmic reticulum, Outer capsid protein, T=13 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4949Sequence AnalysisAdd
BLAST
Chaini50 – 332283Outer capsid glycoprotein VP7PRO_0000369880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi225 – 2251N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

N-glycosylated.By similarity
Intramolecular disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer; in the presence of calcium (By similarity). Acquisition of the capsid outer layer requires a high calcium concentration inside the endoplasmic reticulum. Following cell entry, the low calcium concentration in the cytoplasm is probably responsible for the solubilization of the outer layer (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP7 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001963. VP7.
[Graphical view]
PfamiPF00434. VP7. 1 hit.
[Graphical view]
ProDomiPD000191. VP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q89865-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCTTLYTVC AILFILFIYI LLFRKMFHLI TDTLIVILIL SNCVEWSQGQ
60 70 80 90 100
MFTDDIYYNG NVETIINSTD PFNVESLCIY FPNAVVGSQG PGKSDGHLND
110 120 130 140 150
GNYAQTIATL FETKGFPKGS IILKTYTQTS DFINSVEMTC SYNIVIIPDS
160 170 180 190 200
PNDSESIEQI AEWILNVWRC DDMNLEIYTY EQIGINNLWA AFGSDCDISV
210 220 230 240 250
CPLDTTSNGI GCSPASTETY EVVSNDTQLA LINVVDNVRH RIQMNTAQCK
260 270 280 290 300
LKNCIKGEAR LNTALIRIST SSSFDNSLSP LNNGQTTRSF KINAKKWWTI
310 320 330
FYTIIDYINT IVQAMTPRHR AIYPEGWMLR YA
Length:332
Mass (Da):37,474
Last modified:November 1, 1996 - v1
Checksum:i1DF2115F28FED28A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77257 Genomic RNA. Translation: CAA54475.1.
X77258 Genomic RNA. Translation: CAA54476.1.
U20989 Genomic RNA. Translation: AAC54783.1.
PIRiS41417.
RefSeqiYP_392513.1. NC_007571.1.

Genome annotation databases

GeneIDi3773131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77257 Genomic RNA. Translation: CAA54475.1 .
X77258 Genomic RNA. Translation: CAA54476.1 .
U20989 Genomic RNA. Translation: AAC54783.1 .
PIRi S41417.
RefSeqi YP_392513.1. NC_007571.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773131.

Family and domain databases

InterProi IPR001963. VP7.
[Graphical view ]
Pfami PF00434. VP7. 1 hit.
[Graphical view ]
ProDomi PD000191. VP7. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Sequence conservation of the major outer capsid glycoprotein of human group C rotaviruses."
    Grice A.S., Lambden P.R., Caul E.O., Clarke I.N.
    J. Med. Virol. 44:166-171(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Sequence conservation and expression of the gene encoding the outer capsid glycoprotein among human group C rotaviruses of global distribution."
    Jiang B., Tsunemitsu H., Dennehy P.H., Oishi I., Brown D., Schnagl R.D., Oseto M., Fang Z.Y., Avendano L.F., Saif L.J., Glass R.I.
    Arch. Virol. 141:381-390(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate clinical BF.

Entry informationi

Entry nameiVP7_ROTHC
AccessioniPrimary (citable) accession number: Q89865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3