Reviewed, UniProtKB/Swiss-Prot Q896X8 (GAL1_CLOTE)

Names and origin

Protein names

Recommended name:
    Galactokinase
    EC=2.7.1.6
Alternative name(s):
    Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	CTC_00865

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate phosphorylation Inferred from electronic annotation. Source: InterPro galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP galactokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Galactokinase HAMAP MF_00246		PRO_0000184606
Regions
	Nucleotide binding	126 – 136	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q896X8-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 974E9061DF7CDA94	FASTA	392	44,227
	10 20 30 40 50 60 MVKWRNNMNI NELKKEFIKI YGEGSMRNFF SPGRVNLIGE HIDYNGGHVF PCALNFGTLG 70 80 90 100 110 120 CVRKRKDNKV NLASTNIPLK VSINLEDIKY EKKHGWGNYP KGVIKEIIDK GYKVGGMDIL 130 140 150 160 170 180 ISGNIPNGSG LSSSASLELL IAIMINNIFN DGKLDKVELI KLSQKAENDF VGLNCGIMDQ 190 200 210 220 230 240 FAVAMGKKDM AILLDCNTLE YKYAPVDLGN YVITIMNTNK RRELSDSKYN ERRLECEKAL 250 260 270 280 290 300 KLINKEKKIN YLCELSLEEF ESLKYLIKDN RVLNRATHVV YENERVKRAY YLLSKRNLKE 310 320 330 340 350 360 FGKLLAESHF SLRDLYEVTG KELDAIVGEA LNVSGCIGAR MIGAGFGGCA IALVEKSKLD 370 380 390 LFKKKVSNNY NKIIGYKPGF YTSEIGEGTY EI

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO35462.1.
RefSeq	NP_781525.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1060886.
GenomeReviews	Gene locus CTC_00865 in contig AE015927_GR.
KEGG	ctc:CTC00865.
NMPDR	fig|212717.1.peg.747.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q896X8.
OMA	Q896X8. ISENERT.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_00865-MON.
BRENDA	2.7.1.6. 2082.
Family and domain databases
HAMAP	MF_00246. [Tree]
InterPro	IPR000705. Galactokinase. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal_bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00131. gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_CLOTE

Accession

Primary (citable) accession number: Q896X8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)