ID   URK_CLOTE               Reviewed;         209 AA.
AC   Q896E3;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2003, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Uridine kinase;
DE            EC=2.7.1.48;
DE   AltName: Full=Uridine monophosphokinase;
DE   AltName: Full=Cytidine monophosphokinase;
GN   Name=udk; OrderedLocusNames=CTC_01064;
OS   Clostridium tetani.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   MEDLINE=22457253; PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of
RT   tetanus disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
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DR   EMBL; AE015927; AAO35647.1; -; Genomic_DNA.
DR   RefSeq; NP_781710.1; -.
DR   GeneID; 1059379; -.
DR   GenomeReviews; AE015927_GR; CTC_01064.
DR   KEGG; ctc:CTC01064; -.
DR   NMPDR; fig|212717.1.peg.932; -.
DR   HOGENOM; Q896E3; -.
DR   OMA; Q896E3; NQFIEPT.
DR   BioCyc; CTET212717:CTC_01064-MON; -.
DR   BRENDA; 2.7.1.48; 2082.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:HAMAP.
DR   GO; GO:0008655; P:pyrimidine salvage; IEA:HAMAP.
DR   HAMAP; MF_00551; -; 1.
DR   InterPro; IPR006083; PRK_URK.
DR   InterPro; IPR000764; Uridine_kinase.
DR   PANTHER; PTHR10285:SF6; Uridine_kin; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   TIGRFAMs; TIGR00235; udk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    209       Uridine kinase.
FT                                /FTId=PRO_0000164468.
FT   NP_BIND      12     19       ATP (Potential).
SQ   SEQUENCE   209 AA;  24320 MW;  442207B4BDA2DA93 CRC64;
     MSKRPILIGI TGGTGSGKST VSKEICRRFD KELIVMIEQD SYYKDQSHLS IEERVKTNYD
     HPNAFDTELL VKHLKELSYW SKVEKPIYDF ELHNRKNETE IVEPTEIIIV EGILVLEEKE
     IRDLLDIKIY VDTDADVRII RRLVRDIKER GRSLDSVINQ YLNVVRPMHM QFIEPSKRYA
     DIIIPEGGHN KVAIDIIVGN IKQMVQKSE
//