Reviewed, UniProtKB/Swiss-Prot Q896E3 (URK_CLOTE)

Names and origin

Protein names

Recommended name:
    Uridine kinase
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase
    Cytidine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	CTC_01064

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine salvage Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Uridine kinase HAMAP MF_00551		PRO_0000164468
Regions
	Nucleotide binding	12 – 19	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q896E3-1 [UniParc]. Last modified June 20, 2003. Version 1. Checksum: 442207B4BDA2DA93	FASTA	209	24,320
	10 20 30 40 50 60 MSKRPILIGI TGGTGSGKST VSKEICRRFD KELIVMIEQD SYYKDQSHLS IEERVKTNYD 70 80 90 100 110 120 HPNAFDTELL VKHLKELSYW SKVEKPIYDF ELHNRKNETE IVEPTEIIIV EGILVLEEKE 130 140 150 160 170 180 IRDLLDIKIY VDTDADVRII RRLVRDIKER GRSLDSVINQ YLNVVRPMHM QFIEPSKRYA 190 200 DIIIPEGGHN KVAIDIIVGN IKQMVQKSE

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO35647.1.
RefSeq	NP_781710.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1059379.
GenomeReviews	Gene locus CTC_01064 in contig AE015927_GR.
KEGG	ctc:CTC01064.
NMPDR	fig|212717.1.peg.932.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q896E3.
OMA	Q896E3. NQFIEPT.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_01064-MON.
BRENDA	2.7.1.48. 2082.
Family and domain databases
HAMAP	MF_00551. [Tree]
InterPro	IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view]
PANTHER	PTHR10285:SF6. Uridine_kin. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_CLOTE

Accession

Primary (citable) accession number: Q896E3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	June 20, 2003
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)