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Q89682

- MP1_MNSV

UniProt

Q89682 - MP1_MNSV

Protein

Double gene block protein 1

Gene

ORF2

Organism
Melon necrotic spot virus (MNSV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cell-to-cell movement. Displays RNA-binding activity.1 Publication

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. transmission of virus Source: InterPro
    2. transport of virus in host, cell to cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Viral movement protein

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Double gene block protein 1
    Short name:
    DGBp1
    Alternative name(s):
    Movement protein P7A
    Gene namesi
    ORF Names:ORF2
    OrganismiMelon necrotic spot virus (MNSV)
    Taxonomic identifieri11987 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
    Virus hostiCucumis melo (Muskmelon) [TaxID: 3656]
    Cucumis sativus (Cucumber) [TaxID: 3659]

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi13 – 197RGRSKER → AGASAEA: Complete loss of cell-to-cell movement ability.
    Mutagenesisi25 – 273KQK → AQA: Complete loss of cell-to-cell movement ability.
    Mutagenesisi32 – 332RK → AA: Complete loss of cell-to-cell movement ability. Drastic loss of RNA-binding activity.
    Mutagenesisi43 – 431K → A: 35% loss of cell-to-cell movement ability. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6565Double gene block protein 1PRO_0000398307Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 4327RNA-bindingCuratedAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR007982. Tombusvirus_movement.
    [Graphical view]
    PfamiPF05318. Tombus_movement. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q89682-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSQRTVELT NPRGRSKERG DSGGKQKNSM GRKIANDAIS ESKQGVMGAS   50
    TYIADKIKVT INFNF 65
    Length:65
    Mass (Da):7,121
    Last modified:November 1, 1996 - v1
    Checksum:i31030ADA243F318F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12536 Genomic RNA. Translation: BAA02102.1.
    M29671 Genomic RNA. Translation: AAB02432.1.
    FJ621526 Genomic RNA. Translation: ACT53373.1.
    RefSeqiNP_041229.1. NC_001504.1.

    Genome annotation databases

    GeneIDi1491978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12536 Genomic RNA. Translation: BAA02102.1 .
    M29671 Genomic RNA. Translation: AAB02432.1 .
    FJ621526 Genomic RNA. Translation: ACT53373.1 .
    RefSeqi NP_041229.1. NC_001504.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1491978.

    Family and domain databases

    InterProi IPR007982. Tombusvirus_movement.
    [Graphical view ]
    Pfami PF05318. Tombus_movement. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and genomic organization of melon necrotic spot virus."
      Riviere C.J., Rochon D.M.
      J. Gen. Virol. 71:1887-1896(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Genetic diversity of Melon necrotic spot virus and Olpidium isolates from different origins."
      Herrera-Vasquez J.A., Cordoba-Selles M.C., Cebrian M.C., Rossello J.A., Alfaro-Fernandez A., Jorda C.
      Plant Pathol. 59:240-251(2010)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate Spain/SP-13/2001.
    3. "A self-interacting carmovirus movement protein plays a role in binding of viral RNA during the cell-to-cell movement and shows an actin cytoskeleton dependent location in cell periphery."
      Genoves A., Navarro J.A., Pallas V.
      Virology 395:133-142(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 13-ARG--ARG-19; 25-LYS--LYS-27; 32-LYS-LYS-33 AND LYS-43.

    Entry informationi

    Entry nameiMP1_MNSV
    AccessioniPrimary (citable) accession number: Q89682
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3