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Protein

Double gene block protein 1

Gene

ORF2

Organism
Melon necrotic spot virus (MNSV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell-to-cell movement. Displays RNA-binding activity.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. transmission of virus Source: InterPro
  2. transport of virus in host, cell to cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Viral movement protein

Keywords - Biological processi

Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Double gene block protein 1
Short name:
DGBp1
Alternative name(s):
Movement protein P7A
Gene namesi
ORF Names:ORF2
OrganismiMelon necrotic spot virus (MNSV)
Taxonomic identifieri11987 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
Virus hostiCucumis melo (Muskmelon) [TaxID: 3656]
Cucumis sativus (Cucumber) [TaxID: 3659]

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi13 – 197RGRSKER → AGASAEA: Complete loss of cell-to-cell movement ability. 1 Publication
Mutagenesisi25 – 273KQK → AQA: Complete loss of cell-to-cell movement ability. 1 Publication
Mutagenesisi32 – 332RK → AA: Complete loss of cell-to-cell movement ability. Drastic loss of RNA-binding activity. 1 Publication
Mutagenesisi43 – 431K → A: 35% loss of cell-to-cell movement ability. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Double gene block protein 1PRO_0000398307Add
BLAST

Interactioni

Subunit structurei

Homodimer.Curated

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 4327RNA-bindingCuratedAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007982. Tombusvirus_movement.
[Graphical view]
PfamiPF05318. Tombus_movement. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q89682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQRTVELT NPRGRSKERG DSGGKQKNSM GRKIANDAIS ESKQGVMGAS
60
TYIADKIKVT INFNF
Length:65
Mass (Da):7,121
Last modified:November 1, 1996 - v1
Checksum:i31030ADA243F318F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12536 Genomic RNA. Translation: BAA02102.1.
M29671 Genomic RNA. Translation: AAB02432.1.
FJ621526 Genomic RNA. Translation: ACT53373.1.
RefSeqiNP_041229.1. NC_001504.1.

Genome annotation databases

GeneIDi1491978.
KEGGivg:1491978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12536 Genomic RNA. Translation: BAA02102.1.
M29671 Genomic RNA. Translation: AAB02432.1.
FJ621526 Genomic RNA. Translation: ACT53373.1.
RefSeqiNP_041229.1. NC_001504.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1491978.
KEGGivg:1491978.

Family and domain databases

InterProiIPR007982. Tombusvirus_movement.
[Graphical view]
PfamiPF05318. Tombus_movement. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence and genomic organization of melon necrotic spot virus."
    Riviere C.J., Rochon D.M.
    J. Gen. Virol. 71:1887-1896(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Genetic diversity of Melon necrotic spot virus and Olpidium isolates from different origins."
    Herrera-Vasquez J.A., Cordoba-Selles M.C., Cebrian M.C., Rossello J.A., Alfaro-Fernandez A., Jorda C.
    Plant Pathol. 59:240-251(2010)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Spain/SP-13/2001.
  3. "A self-interacting carmovirus movement protein plays a role in binding of viral RNA during the cell-to-cell movement and shows an actin cytoskeleton dependent location in cell periphery."
    Genoves A., Navarro J.A., Pallas V.
    Virology 395:133-142(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 13-ARG--ARG-19; 25-LYS--LYS-27; 32-LYS-LYS-33 AND LYS-43.

Entry informationi

Entry nameiMP1_MNSV
AccessioniPrimary (citable) accession number: Q89682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.