Q89662 (DUT_ADEG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

ORF Names:

1

Organism

Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) [Reference proteome]

Taxonomic identifier

10553 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Aviadenovirus › Fowl adenovirus A

Virus host

Galliformes [TaxID: 8976]

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182967
Experimental info
	Sequence conflict	156	1	S → F in AAB26434. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q89662 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 477C885A944D16F1	FASTA	178	19,219
	10 20 30 40 50 60 MDPFGSSSVP PCSTSDLPEP KLYFVRLSPH AVPPVRATHG AAGYDLFSAY DIKVPARGRA 70 80 90 100 110 120 LVPTDLVFQF PPGCYGRIAP RSGLAAKFFI DVGAGVIDPD YRGNVSVVLF NFSESSFNIR 130 140 150 160 170 RGDRVAQLIL ERIMVPELSE LTQLGETDRG ASGFGSTGMG AVDRNQRSVL EWLTPGSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of a fragment (92-100%) of the CELO avian adenovirus genome." Akopian T.A., Kaverina E.N., Naroditskii B.S., Tikhonenko T.I. Mol. Genet. Mikrobiol. Virusol. 11:19-23(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete DNA sequence and genomic organization of the avian adenovirus CELO." Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M. J. Virol. 70:2939-2949(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z17216 Genomic DNA. Translation: CAA78921.1. S61107 Genomic DNA. Translation: AAB26434.1. U46933 Genomic DNA. Translation: AAC54895.1.
PIR	S26429.
RefSeq	NP_043869.1. NC_001720.1.
3D structure databases
ProteinModelPortal	Q89662.
SMR	Q89662. Positions 21-158.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1733464.
Phylogenomic databases
ProtClustDB	CLSP2510115.
Enzyme and pathway databases
UniPathway	UPA00610; UER00666.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DUT_ADEG1

Accession

Primary (citable) accession number: Q89662
Secondary accession number(s): Q86612

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program