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Q89662

- DUT_ADEG1

UniProt

Q89662 - DUT_ADEG1

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
1
Organism
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:1
OrganismiFowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
Taxonomic identifieri10553 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeAviadenovirusFowl adenovirus A
Virus hostiGalliformes [TaxID: 8976]
ProteomesiUP000001594: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182967Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ89662.
SMRiQ89662. Positions 21-158.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89662-1 [UniParc]FASTAAdd to Basket

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MDPFGSSSVP PCSTSDLPEP KLYFVRLSPH AVPPVRATHG AAGYDLFSAY    50
DIKVPARGRA LVPTDLVFQF PPGCYGRIAP RSGLAAKFFI DVGAGVIDPD 100
YRGNVSVVLF NFSESSFNIR RGDRVAQLIL ERIMVPELSE LTQLGETDRG 150
ASGFGSTGMG AVDRNQRSVL EWLTPGSR 178
Length:178
Mass (Da):19,219
Last modified:November 1, 1996 - v1
Checksum:i477C885A944D16F1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561S → F in AAB26434. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17216 Genomic DNA. Translation: CAA78921.1.
S61107 Genomic DNA. Translation: AAB26434.1.
U46933 Genomic DNA. Translation: AAC54895.1.
PIRiS26429.
RefSeqiNP_043869.1. NC_001720.1.

Genome annotation databases

GeneIDi1733464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z17216 Genomic DNA. Translation: CAA78921.1 .
S61107 Genomic DNA. Translation: AAB26434.1 .
U46933 Genomic DNA. Translation: AAC54895.1 .
PIRi S26429.
RefSeqi NP_043869.1. NC_001720.1.

3D structure databases

ProteinModelPortali Q89662.
SMRi Q89662. Positions 21-158.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1733464.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the nucleotide sequence of a fragment (92-100%) of the CELO avian adenovirus genome."
    Akopian T.A., Kaverina E.N., Naroditskii B.S., Tikhonenko T.I.
    Mol. Genet. Mikrobiol. Virusol. 11:19-23(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence and genomic organization of the avian adenovirus CELO."
    Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M.
    J. Virol. 70:2939-2949(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_ADEG1
AccessioniPrimary (citable) accession number: Q89662
Secondary accession number(s): Q86612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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