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Q89662

- DUT_ADEG1

UniProt

Q89662 - DUT_ADEG1

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

1

Organism
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    ORF Names:1
    OrganismiFowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
    Taxonomic identifieri10553 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeAviadenovirusFowl aviadenovirus A
    Virus hostiGalliformes [TaxID: 8976]
    ProteomesiUP000001594: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182967Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ89662.
    SMRiQ89662. Positions 21-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q89662-1 [UniParc]FASTAAdd to Basket

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    MDPFGSSSVP PCSTSDLPEP KLYFVRLSPH AVPPVRATHG AAGYDLFSAY    50
    DIKVPARGRA LVPTDLVFQF PPGCYGRIAP RSGLAAKFFI DVGAGVIDPD 100
    YRGNVSVVLF NFSESSFNIR RGDRVAQLIL ERIMVPELSE LTQLGETDRG 150
    ASGFGSTGMG AVDRNQRSVL EWLTPGSR 178
    Length:178
    Mass (Da):19,219
    Last modified:November 1, 1996 - v1
    Checksum:i477C885A944D16F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561S → F in AAB26434. (PubMed:1338734)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17216 Genomic DNA. Translation: CAA78921.1.
    S61107 Genomic DNA. Translation: AAB26434.1.
    U46933 Genomic DNA. Translation: AAC54895.1.
    PIRiS26429.
    RefSeqiNP_043869.1. NC_001720.1.

    Genome annotation databases

    GeneIDi1733464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z17216 Genomic DNA. Translation: CAA78921.1 .
    S61107 Genomic DNA. Translation: AAB26434.1 .
    U46933 Genomic DNA. Translation: AAC54895.1 .
    PIRi S26429.
    RefSeqi NP_043869.1. NC_001720.1.

    3D structure databases

    ProteinModelPortali Q89662.
    SMRi Q89662. Positions 21-158.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1733464.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the nucleotide sequence of a fragment (92-100%) of the CELO avian adenovirus genome."
      Akopian T.A., Kaverina E.N., Naroditskii B.S., Tikhonenko T.I.
      Mol. Genet. Mikrobiol. Virusol. 11:19-23(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence and genomic organization of the avian adenovirus CELO."
      Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M.
      J. Virol. 70:2939-2949(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_ADEG1
    AccessioniPrimary (citable) accession number: Q89662
    Secondary accession number(s): Q86612
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3