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Q89662 (DUT_ADEG1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
ORF Names:1
OrganismFowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) [Reference proteome]
Taxonomic identifier10553 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageAdenoviridaeAviadenovirusFowl adenovirus A
Virus hostGalliformes [TaxID: 8976]

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182967

Experimental info

Sequence conflict1561S → F in AAB26434. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q89662 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 477C885A944D16F1

FASTA17819,219
        10         20         30         40         50         60 
MDPFGSSSVP PCSTSDLPEP KLYFVRLSPH AVPPVRATHG AAGYDLFSAY DIKVPARGRA 

        70         80         90        100        110        120 
LVPTDLVFQF PPGCYGRIAP RSGLAAKFFI DVGAGVIDPD YRGNVSVVLF NFSESSFNIR 

       130        140        150        160        170 
RGDRVAQLIL ERIMVPELSE LTQLGETDRG ASGFGSTGMG AVDRNQRSVL EWLTPGSR 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of a fragment (92-100%) of the CELO avian adenovirus genome."
Akopian T.A., Kaverina E.N., Naroditskii B.S., Tikhonenko T.I.
Mol. Genet. Mikrobiol. Virusol. 11:19-23(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence and genomic organization of the avian adenovirus CELO."
Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M.
J. Virol. 70:2939-2949(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z17216 Genomic DNA. Translation: CAA78921.1.
S61107 Genomic DNA. Translation: AAB26434.1.
U46933 Genomic DNA. Translation: AAC54895.1.
PIRS26429.
RefSeqNP_043869.1. NC_001720.1.

3D structure databases

ProteinModelPortalQ89662.
SMRQ89662. Positions 21-158.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1733464.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

Gene3D2.70.40.10. 1 hit.
InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 1 hit.
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_ADEG1
AccessionPrimary (citable) accession number: Q89662
Secondary accession number(s): Q86612
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways