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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

1

Organism
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:1
OrganismiFowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
Taxonomic identifieri10553 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeAviadenovirusFowl aviadenovirus A
Virus hostiGalliformes [TaxID: 8976]
ProteomesiUP000001594: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182967Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ89662.
SMRiQ89662. Positions 21-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

Q89662-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPFGSSSVP PCSTSDLPEP KLYFVRLSPH AVPPVRATHG AAGYDLFSAY
60 70 80 90 100
DIKVPARGRA LVPTDLVFQF PPGCYGRIAP RSGLAAKFFI DVGAGVIDPD
110 120 130 140 150
YRGNVSVVLF NFSESSFNIR RGDRVAQLIL ERIMVPELSE LTQLGETDRG
160 170
ASGFGSTGMG AVDRNQRSVL EWLTPGSR
Length:178
Mass (Da):19,219
Last modified:November 1, 1996 - v1
Checksum:i477C885A944D16F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561S → F in AAB26434. (PubMed:1338734)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17216 Genomic DNA. Translation: CAA78921.1.
S61107 Genomic DNA. Translation: AAB26434.1.
U46933 Genomic DNA. Translation: AAC54895.1.
PIRiS26429.
RefSeqiNP_043869.1. NC_001720.1.

Genome annotation databases

GeneIDi1733464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z17216 Genomic DNA. Translation: CAA78921.1.
S61107 Genomic DNA. Translation: AAB26434.1.
U46933 Genomic DNA. Translation: AAC54895.1.
PIRiS26429.
RefSeqiNP_043869.1. NC_001720.1.

3D structure databases

ProteinModelPortaliQ89662.
SMRiQ89662. Positions 21-158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1733464.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the nucleotide sequence of a fragment (92-100%) of the CELO avian adenovirus genome."
    Akopian T.A., Kaverina E.N., Naroditskii B.S., Tikhonenko T.I.
    Mol. Genet. Mikrobiol. Virusol. 11:19-23(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence and genomic organization of the avian adenovirus CELO."
    Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M.
    J. Virol. 70:2939-2949(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_ADEG1
AccessioniPrimary (citable) accession number: Q89662
Secondary accession number(s): Q86612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.