Reviewed, UniProtKB/Swiss-Prot Q895U7 (PUR7_CLOTE)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	CTC_01170

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_0000100819

Sequences

	Sequence		Length	Mass (Da)
	Q895U7-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 89BC780B433030F0	FASTA	227	25,699
	10 20 30 40 50 60 MNVVYKGKTK DVFLLEDGNY LLKFKDDVTG ENGVFDPGAN SVGLTMEGAG RAALRLTKLF 70 80 90 100 110 120 FERLKEEKIP THYIDSNVEE GTMKVKPAKI FGNGLEVICR YRAVGSFMRR YGMYAKEGQV 130 140 150 160 170 180 LDAFVEVTLK DDERQDPPIT KDALDMLGIL SLREYDILKD LTKKISGIVK DELSKKGIEL 190 200 210 220 YDIKLEFGRI DEDNHIALID EISGGNMRAY KDGEYIEPLD LEKLIIE

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO35743.1.
RefSeq	NP_781806.1.
3D structure databases
HSSP	HSSP built from PDB template 1KUT based on UniProtKB Q9X0X0.
ModBase	Search...
Genome annotation databases
GeneID	1059290.
GenomeReviews	Gene locus CTC_01170 in contig AE015927_GR.
KEGG	ctc:CTC01170.
NMPDR	fig|212717.1.peg.1028.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q895U7.
OMA	Q895U7. GLEVICR.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_01170-MON.
BRENDA	6.3.2.6. 2082.
Family and domain databases
HAMAP	MF_00137. Divergent sequence. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
ProDom	PD003043. SAICAR_synt. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01057. SAICAR_SYNTHETASE_1. False negative. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_CLOTE

Accession

Primary (citable) accession number: Q895U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)