ID   Q895R0_CLOTE            Unreviewed;       571 AA.
AC   Q895R0;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   SubName: Full=Methyl-accepting chemotaxis protein tlpA {ECO:0000313|EMBL:AAO35780.1};
GN   Name=tlpA {ECO:0000313|EMBL:AAO35780.1};
GN   OrderedLocusNames=CTC_01211 {ECO:0000313|EMBL:AAO35780.1};
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717 {ECO:0000313|EMBL:AAO35780.1, ECO:0000313|Proteomes:UP000001412};
RN   [1] {ECO:0000313|EMBL:AAO35780.1, ECO:0000313|Proteomes:UP000001412}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88 {ECO:0000313|Proteomes:UP000001412};
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I.,
RA   Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT   disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE015927; AAO35780.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q895R0; -.
DR   STRING; 212717.CTC_01211; -.
DR   KEGG; ctc:CTC_01211; -.
DR   HOGENOM; CLU_000445_107_27_9; -.
DR   OrthoDB; 1887545at2; -.
DR   Proteomes; UP000001412; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR024478; HlyB_4HB_MCP.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF12729; 4HB_MCP_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001412};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          213..265
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          284..521
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   COILED          327..372
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   571 AA;  63500 MW;  2A1467F1BC033055 CRC64;
     MVKLRKNLKL AQKLILSYIL IALLIAIVGF IGVFNMQKVN NSGERLYHEG LLGINSVRNI
     KENFLTIGAN TLLMASQENL GRVSYLENDV KKLFNHNNEL FNIYEKTIIT RENKGIYNRL
     RKSSSDYRSI HNEIMNAVKK NDYKKAKFHV NQISEVRDIM FSQLNELIDL NIKMSREAKA
     VSTSTYDKSF KIIIMSIVLG FILSITMGWV TSSKIIKNIK KTEDFAKAIG KGDLTKDIDI
     KADDEIGEIA KSLNNAKENI RTIINEIEIS ARDIGVGSEE LSAITEEVYS KVEAANESLT
     EITKGSQDLS ATAEEVSAST EDIGSTIREL AQRSDNFHET VENIKNRAVD IKNKATEAIE
     NSEMIYNKHE KDLIKSIEEG EIVEDIKIMA ESIGNIAEQT NLLALNAAIE AARAGEHGRG
     FAVVAEEVRK LAEESTNAVA EIQTMVNKIQ GAFYSLSENG KSILEFMETN VKPTYELLKD
     TGENYEIDAE MIEEIMEYIS LSSNQISASI EQVNVAIRNV SDTAEESAAG SKEIMAGANE
     TAIAMEEVST STETQSELAS KLNNVISKFK I
//