Reviewed, UniProtKB/Swiss-Prot Q895N2 (ACKA_CLOTE)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	CTC_01240

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Acetate kinase HAMAP MF_00020		PRO_0000107548

Sequences

	Sequence		Length	Mass (Da)
	Q895N2-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 5F3E58460E4362A4	FASTA	400	44,230
	10 20 30 40 50 60 MKILVINCGS SSLKYQFINM TNEDVLAKGL VERIGMEGSI LTHKVNDEKY VIQEPMKDHK 70 80 90 100 110 120 DAIKLVLDAL TDKEHGVIED MSEISSVGHR VVHGGEKYAN SVLIDEDVMK SLEECIKLAP 130 140 150 160 170 180 LHNPPNIIGI NACKALMPNT PMVAVFDTAF HQTIPEYAYI YPLPYELYKK YGIRKYGFHG 190 200 210 220 230 240 TSHRYVSKRV AELMGKDIKD LKIITCHLGN GASICAVNEG KSVETSMGFT PLEGIAMGTR 250 260 270 280 290 300 SGSIDPAILP FLMKELNLNL DDLNNLLNKK SGVYGISGVS SDFRDIEEAA EEGNDRAKLA 310 320 330 340 350 360 LDVFHYKVRR FIGSYAAAMG GVDCVVFTAG LGENSAESRE EICKNLEFLG IKINEKKNNE 370 380 390 400 GRGFAKVISE DNSKVKVFVI PTDEELMIAR DTNEIVSNLK

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO35808.1.
RefSeq	NP_781871.1.
3D structure databases
HSSP	HSSP built from PDB template 1G99 based on UniProtKB P38502.
ModBase	Search...
Genome annotation databases
GeneID	1059142.
GenomeReviews	Gene locus CTC_01240 in contig AE015927_GR.
KEGG	ctc:CTC01240.
NMPDR	fig|212717.1.peg.1093.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q895N2.
OMA	Q895N2. SSDFRDV.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_01240-MON.
BRENDA	2.7.2.1. 2082.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CLOTE

Accession

Primary (citable) accession number: Q895N2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)