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Q89569

- VSGP_EBORS

UniProt

Q89569 - VSGP_EBORS

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Protein

Pre-small/secreted glycoprotein

Gene
GP
Organism
Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils By similarity.
Delta-peptide does not seem to be involved in activation of primary macrophages By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei325 – 3262Cleavage; by host furin By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-small/secreted glycoprotein
Short name:
pre-sGP
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiReston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)
Taxonomic identifieri129004 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Pteropodinae [TaxID: 77225]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 367334Pre-small/secreted glycoprotein By similarityPRO_0000037500Add
BLAST
Chaini34 – 325292Small/secreted glycoprotein By similarityPRO_0000037501Add
BLAST
Chaini326 – 36742Delta-peptide By similarityPRO_0000037502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi54 – 54Interchain By similarity
Disulfide bondi109 ↔ 136 By similarity
Disulfide bondi122 ↔ 148 By similarity
Glycosylationi205 – 2051N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi258 – 2581N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi269 – 2691N-linked (GlcNAc...); by host Reviewed prediction
Disulfide bondi307 – 307Interchain By similarity

Post-translational modificationi

Pre-sGP is N-glycosylated. This precursor is processed into mature sGP and delta-peptide by host furin or furin-like proteases. The cleavage site corresponds to the furin optimal cleavage sequence [KR]-X-[KR]-R. Both cleavage fragments contain sialic acid, but only the delta-peptide is O-glycosylated By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

sGP is a homodimer; disulfide-linked. The homodimers are linked by two disulfide bonds in a parallel orientation. Delta-peptide is a monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ89569.
SMRiQ89569. Positions 33-285.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR014625. GPC_FiloV.
IPR002561. GPC_filovir-type_extra_dom.
[Graphical view]
PfamiPF01611. Filo_glycop. 1 hit.
[Graphical view]
PIRSFiPIRSF036874. GPC_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q89569-1 [UniParc]FASTAAdd to Basket

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MGSGYQLLQL PRERFRKTSF LVWVIILFQR AISMPLGIVT NSTLKATEID    50
QLVCRDKLSS TSQLKSVGLN LEGNGIATDV PSATKRWGFR SGVPPKVVSY 100
EAGEWAENCY NLEIKKSDGS ECLPLPPDGV RGFPRCRYVH KVQGTGPCPG 150
DLAFHKNGAF FLYDRLASTV IYRGTTFTEG VVAFLILSEP KKHFWKATPA 200
HEPVNTTDDS TSYYMTLTLS YEMSNFGGKE SNTLFKVDNH TYVQLDRPHT 250
PQFLVQLNET LRRNNRLSNS TGRLTWTLDP KIEPDVGEWA FWETKKTFPN 300
NFMEKTCISK FYQPTPTTPQ IRARRELSKE KLATTHPPTT PSWFQRIPLQ 350
WFQCSLQDGQ RKCRPKV 367
Length:367
Mass (Da):41,815
Last modified:November 1, 1996 - v1
Checksum:iA42EEDD45D6A6949
GO

RNA editingi

Partially edited. RNA editing at this position consists of an insertion of one adenine nucleotide. The sequence displayed here is the small secreted glycoprotein, derived from the unedited RNA. The edited RNA gives rise to the full-length transmembrane glycoprotein (AC Q89853).1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23416 Genomic RNA. Translation: AAC54888.1.
U23417 Genomic RNA. Translation: AAC54890.1.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23416 Genomic RNA. Translation: AAC54888.1 .
U23417 Genomic RNA. Translation: AAC54890.1 .

3D structure databases

ProteinModelPortali Q89569.
SMRi Q89569. Positions 33-285.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR014625. GPC_FiloV.
IPR002561. GPC_filovir-type_extra_dom.
[Graphical view ]
Pfami PF01611. Filo_glycop. 1 hit.
[Graphical view ]
PIRSFi PIRSF036874. GPC_FiloV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing."
    Sanchez A., Trappier S.G., Mahy B.W.J., Peters C.J., Nichol S.T.
    Proc. Natl. Acad. Sci. U.S.A. 93:3602-3607(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], RNA EDITING.

Entry informationi

Entry nameiVSGP_EBORS
AccessioniPrimary (citable) accession number: Q89569
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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