Q894H2 (PPNK_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	CTC_01573

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000120613

Sequences

	Sequence		Length	Mass (Da)
	Q894H2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 2272E819BC649D58	FASTA	274	30,725
	10 20 30 40 50 60 MRYIGINVNT GKDVEGRLLK KIVEAIEDNC KDVEVKIYKD SIGLEKKETE NLEVVIVLGG 70 80 90 100 110 120 DGTILKASKY LAKYNVPILG INIGNLGFLT ETESSNFIFS IRNYFKGKYY IEERNMVQCT 130 140 150 160 170 180 TEYKGIKKEF HGLNDIVVTK GDVGKTAKYD LYIDGNFYTK LSSDGVIVST STGSTAYSLS 190 200 210 220 230 240 AGGPIIYPTL DALCLTPICG HSLRIRSIVL NHKSIIKIIS QSENVILTVD GEEINFLENV 250 260 270 KEFLITSSPY KCKLIKLEGE HRDYYSILRN KLYL

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015927 Genomic DNA. Translation: AAO36120.1.
RefSeq	NP_782183.1. NC_004557.1.
3D structure databases
ProteinModelPortal	Q894H2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1059714.
GenomeReviews	Gene locus CTC_01573 in contig AE015927_GR.
KEGG	ctc:CTC01573.
NMPDR	fig|212717.1.peg.1405.
PATRIC	19511181. VBICloTet101274_1638.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
OMA	HSAREEV.
PhylomeDB	Q894H2.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_01573-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_CLOTE

Accession

Primary (citable) accession number: Q894H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program