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Q894H2

- NADK_CLOTE

UniProt

Q894H2 - NADK_CLOTE

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Protein

NAD kinase

Gene

nadK

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptorUniRule annotation
Binding sitei66 – 661NADUniRule annotation
Binding sitei145 – 1451NADUniRule annotation
Binding sitei164 – 1641NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NADUniRule annotation
Nucleotide bindingi134 – 1352NADUniRule annotation
Nucleotide bindingi175 – 1806NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTET212717:GJAM-1450-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:CTC_01573
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274NAD kinasePRO_0000120613Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC01573.

Structurei

3D structure databases

ProteinModelPortaliQ894H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiESSNFIF.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q894H2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRYIGINVNT GKDVEGRLLK KIVEAIEDNC KDVEVKIYKD SIGLEKKETE
60 70 80 90 100
NLEVVIVLGG DGTILKASKY LAKYNVPILG INIGNLGFLT ETESSNFIFS
110 120 130 140 150
IRNYFKGKYY IEERNMVQCT TEYKGIKKEF HGLNDIVVTK GDVGKTAKYD
160 170 180 190 200
LYIDGNFYTK LSSDGVIVST STGSTAYSLS AGGPIIYPTL DALCLTPICG
210 220 230 240 250
HSLRIRSIVL NHKSIIKIIS QSENVILTVD GEEINFLENV KEFLITSSPY
260 270
KCKLIKLEGE HRDYYSILRN KLYL
Length:274
Mass (Da):30,725
Last modified:June 1, 2003 - v1
Checksum:i2272E819BC649D58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36120.1.
RefSeqiNP_782183.1. NC_004557.1.
WP_011099780.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO36120; AAO36120; CTC_01573.
GeneIDi1059714.
KEGGictc:CTC01573.
PATRICi19511181. VBICloTet101274_1638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36120.1 .
RefSeqi NP_782183.1. NC_004557.1.
WP_011099780.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q894H2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212717.CTC01573.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO36120 ; AAO36120 ; CTC_01573 .
GeneIDi 1059714.
KEGGi ctc:CTC01573.
PATRICi 19511181. VBICloTet101274_1638.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi ESSNFIF.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci CTET212717:GJAM-1450-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiNADK_CLOTE
AccessioniPrimary (citable) accession number: Q894H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3