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Q894H2

- NADK_CLOTE

UniProt

Q894H2 - NADK_CLOTE

Protein

NAD kinase

Gene

nadK

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei61 – 611Proton acceptorUniRule annotation
    Binding sitei66 – 661NADUniRule annotation
    Binding sitei145 – 1451NADUniRule annotation
    Binding sitei164 – 1641NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 622NADUniRule annotation
    Nucleotide bindingi134 – 1352NADUniRule annotation
    Nucleotide bindingi175 – 1806NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTET212717:GJAM-1450-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:CTC_01573
    OrganismiClostridium tetani (strain Massachusetts / E88)
    Taxonomic identifieri212717 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001412: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274NAD kinasePRO_0000120613Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi212717.CTC01573.

    Structurei

    3D structure databases

    ProteinModelPortaliQ894H2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiESSNFIF.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q894H2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYIGINVNT GKDVEGRLLK KIVEAIEDNC KDVEVKIYKD SIGLEKKETE    50
    NLEVVIVLGG DGTILKASKY LAKYNVPILG INIGNLGFLT ETESSNFIFS 100
    IRNYFKGKYY IEERNMVQCT TEYKGIKKEF HGLNDIVVTK GDVGKTAKYD 150
    LYIDGNFYTK LSSDGVIVST STGSTAYSLS AGGPIIYPTL DALCLTPICG 200
    HSLRIRSIVL NHKSIIKIIS QSENVILTVD GEEINFLENV KEFLITSSPY 250
    KCKLIKLEGE HRDYYSILRN KLYL 274
    Length:274
    Mass (Da):30,725
    Last modified:June 1, 2003 - v1
    Checksum:i2272E819BC649D58
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36120.1.
    RefSeqiNP_782183.1. NC_004557.1.

    Genome annotation databases

    EnsemblBacteriaiAAO36120; AAO36120; CTC_01573.
    GeneIDi1059714.
    KEGGictc:CTC01573.
    PATRICi19511181. VBICloTet101274_1638.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36120.1 .
    RefSeqi NP_782183.1. NC_004557.1.

    3D structure databases

    ProteinModelPortali Q894H2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212717.CTC01573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO36120 ; AAO36120 ; CTC_01573 .
    GeneIDi 1059714.
    KEGGi ctc:CTC01573.
    PATRICi 19511181. VBICloTet101274_1638.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi ESSNFIF.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CTET212717:GJAM-1450-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Massachusetts / E88.

    Entry informationi

    Entry nameiNADK_CLOTE
    AccessioniPrimary (citable) accession number: Q894H2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3