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Q894C9 (AROB_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:CTC_01620
OrganismClostridium tetani [Complete proteome] [HAMAP]
Taxonomic identifier1513 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3733733-dehydroquinate synthase HAMAP MF_00110
PRO_0000140732

Sequences

Sequence LengthMass (Da)Tools
Q894C9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6C22E271867FD4C1

FASTA37343,618
        10         20         30         40         50         60 
MSEIFYNIVR RVRRDTMREI EVEGDNRYKI YIDTNLDKLY KAFEDYKIKS NSEMFLITDD 

        70         80         90        100        110        120 
KVYSIYKDRI EMLKNIYNIK EFYFKNGEEN KTLETLQEIY SFLMENNAKR NSIIIALGGG 

       130        140        150        160        170        180 
VVGDLVGFVA STYMRGVRYI NIPTTLLSQI DSCVGGKVGY NYKGIKNLIG SFYNPEFVFI 

       190        200        210        220        230        240 
STNFLKTLDF QRFKDGLGEV IKYGLILDEE IISFIEENYK GVLEKESDKL LYITRTCLIL 

       250        260        270        280        290        300 
KKQVIEMDYK DLGFRNILNF GHTIGHAIEM TSKNKITHGE AVALGMLVSL KLSEHIYGLD 

       310        320        330        340        350        360 
KNLYYRMEKL YKKLGLPTKY KVDNYNLFMY AINHDKKNKD NIRFVLLKDV EKPEVKIEVN 

       370 
KEEILKAIEE SIN

« Hide

References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015927 Genomic DNA. Translation: AAO36163.1.
RefSeqNP_782226.1. NC_004557.1.

3D structure databases

ProteinModelPortalQ894C9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1059800.
GenomeReviewsGene locus CTC_01620 in contig AE015927_GR.
KEGGctc:CTC01620.
NMPDRfig|212717.1.peg.1448.
PATRIC19511279. VBICloTet101274_1687.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMADSCIGSK.
PhylomeDBQ894C9.
ProtClustDBCLSK912196.

Enzyme and pathway databases

BioCycCTET212717:CTC_01620-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_CLOTE
AccessionPrimary (citable) accession number: Q894C9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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