Reviewed, UniProtKB/Swiss-Prot Q893Q3 (GLPK1_CLOTE)

Names and origin

Protein names

Recommended name:
    Glycerol kinase 1
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase 1
    Glycerokinase 1
      Short name=GK 1

Gene names

Name:	glpK1
Ordered Locus Names:	CTC_01758

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glycerol kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Glycerol kinase 1 HAMAP MF_00186		PRO_0000059445
Regions
	Nucleotide binding	409 – 413	5	ATP By similarity
Sites
	Binding site	12	1	Substrate By similarity
	Binding site	16	1	ATP By similarity
	Binding site	82	1	Substrate By similarity
	Binding site	134	1	Substrate By similarity
	Binding site	243	1	Substrate By similarity
	Binding site	265	1	ATP By similarity
	Binding site	308	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q893Q3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C69BC72DBF023DFD	FASTA	498	55,362
	10 20 30 40 50 60 MAKYVMALDQ GTTSSRCIIF NERGLIVSVA QREFKQIYPK GGWVEHDPME IWATQFSVAT 70 80 90 100 110 120 EAMAKANIEA SEIASIGITN QRETTIVWDK RTGLPVYNAI VWQCRRTAQI CDELKEKGLT 130 140 150 160 170 180 ETIRNKTGLV LDAYFSGTKI KWILDNVAGA REEAEKGNLI FGTVDTWLIW NLTKGKVHVT 190 200 210 220 230 240 DYSNASRTMI YNIHELKWDD ELLEALDIPK SMLPEVKPSS YVYGETNSTL FGSSIPIAGV 250 260 270 280 290 300 AGDQQAALFG QMCHQEGTAK STYGTGCFLL MNTGEKAVKS ENGLLTTIAF GIDDKVEYAL 310 320 330 340 350 360 EGSIFIGGAA IQWLRDELRM LKDSPESERY ATAVEDTNGV YMVPAFVGLG APYWDPYARG 370 380 390 400 410 420 AIVGLTRGAT KEHFIRATLE SLAYQTYDVL NAMREDSGID LKALRVDGGA SANDFLMQFQ 430 440 450 460 470 480 ADILGVPVQR PEVIETTALG AAYLAGLAVG YWKDKKDVAQ NWAISKTFEP DMIKERREEL 490 LEGWHEAVKR SMNWEKSE

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO36289.1.
RefSeq	NP_782352.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1060931.
GenomeReviews	Gene locus CTC_01758 in contig AE015927_GR.
KEGG	ctc:CTC01758.
NMPDR	fig|212717.1.peg.1574.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q893Q3.
OMA	IAQREFT.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_01758-MON.
BRENDA	2.7.1.30. 2082.
Family and domain databases
HAMAP	MF_00186. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK1_CLOTE

Accession

Primary (citable) accession number: Q893Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)