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Q892X3

- PUR9_CLOTE

UniProt

Q892X3 - PUR9_CLOTE

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCTET212717:GJAM-1799-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:CTC_01962
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Bifunctional purine biosynthesis protein PurHPRO_0000192086Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC01962.

Structurei

3D structure databases

ProteinModelPortaliQ892X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q892X3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKRALISVY NKEGILEFAK FLEKNHVEII STGGTYKHLK DNCVRVKEVS
60 70 80 90 100
QITNFDEILD GRVKTLHPAV HGGILAIRDN KEHMDTIKDK NIEPIDMVIV
110 120 130 140 150
NLYPFFEKIG KGLSLEEQIE FIDIGGPTMI RAAAKNFKDV VVITDPKDYK
160 170 180 190 200
RIEEKLEKED EIDFNNRKTL AGKVFNLMSA YDGAISKFLL EEEYPEYLSL
210 220 230 240 250
SYKKGKDLRY GENPHQTAAF YTSLTEDGAF KDFEKLNGKE LSYNNIKDMD
260 270 280 290 300
VAWKIVGEFE EIACCALKHN SPCGVAIGDT LLESYKKAYE CDPISIFGGI
310 320 330 340 350
VAFNRKVNKE TAKELVKIFL EVIIAPDYDE DALRILKGKK NLRVIKCNTK
360 370 380 390 400
PLDKMEICKV DVGILVQSTD NALIKDMDVV TAKKPTEEEM ENMIFAMKVV
410 420 430 440 450
KYVKSNAIVV VKDKKAVGIA GGQVNRIWAA CQALERGNNS VVLASDAFFP
460 470 480 490
FDDVVKKASE YGIKAIIQPG GSIRDKDSIE ECDEKGISMV FTGIRHFKH
Length:499
Mass (Da):56,183
Last modified:June 20, 2003 - v1
Checksum:i17F1CB10527AF3BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA. Translation: AAO36469.1.
RefSeqiNP_782532.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO36469; AAO36469; CTC_01962.
GeneIDi1059924.
KEGGictc:CTC01962.
PATRICi19511975. VBICloTet101274_2035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA. Translation: AAO36469.1 .
RefSeqi NP_782532.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q892X3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212717.CTC01962.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO36469 ; AAO36469 ; CTC_01962 .
GeneIDi 1059924.
KEGGi ctc:CTC01962.
PATRICi 19511975. VBICloTet101274_2035.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CTET212717:GJAM-1799-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiPUR9_CLOTE
AccessioniPrimary (citable) accession number: Q892X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3