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Q892X1

- PUR5_CLOTE

UniProt

Q892X1 - PUR5_CLOTE

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, CTC_01964
Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTET212717:GJAM-1801-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:CTC_01964
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_0000148207Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC01964.

Structurei

3D structure databases

ProteinModelPortaliQ892X1.
SMRiQ892X1. Positions 17-326.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiPRIYGND.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q892X1-1 [UniParc]FASTAAdd to Basket

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MATYKDAGVN IEEGYKSVNL MKEHVQKTFN KGVLNGIGSF AAMYELGKYK    50
NPVLVSGTDG VGTKLKIAFE LEKYNTIGID CVAMCVNDIL CHGAKPLFFL 100
DYMACGKLKG EVAADIVKGV SDGCLRAGCA LIGGETAEMP GFYKEGEYDI 150
AGFAVGIVEK ENIVDGQDIK EGDVLIGIAS SGVHSNGYSL VRSVIKDFRE 200
EFHGKIIGEE LLTPTKIYVK PVLQLLKSYP IKGMAHITGG GFYENIPRMF 250
KDDLNVVISK NSFPRPDIFE YIISKGIEEN HMFNVFNMGI GFVLCVDPCY 300
EKKIIEKLIE QGEKAYKIGH IEKGERKVII K 331
Length:331
Mass (Da):36,424
Last modified:June 1, 2003 - v1
Checksum:iB03A0FAA96973EB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36471.1.
RefSeqiNP_782534.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO36471; AAO36471; CTC_01964.
GeneIDi1060242.
KEGGictc:CTC01964.
PATRICi19511979. VBICloTet101274_2037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36471.1 .
RefSeqi NP_782534.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q892X1.
SMRi Q892X1. Positions 17-326.
ModBasei Search...

Protein-protein interaction databases

STRINGi 212717.CTC01964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO36471 ; AAO36471 ; CTC_01964 .
GeneIDi 1060242.
KEGGi ctc:CTC01964.
PATRICi 19511979. VBICloTet101274_2037.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi PRIYGND.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CTET212717:GJAM-1801-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiPUR5_CLOTE
AccessioniPrimary (citable) accession number: Q892X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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