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Q892X1

- PUR5_CLOTE

UniProt

Q892X1 - PUR5_CLOTE

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTET212717:GJAM-1801-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:CTC_01964
    OrganismiClostridium tetani (strain Massachusetts / E88)
    Taxonomic identifieri212717 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001412: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148207Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi212717.CTC01964.

    Structurei

    3D structure databases

    ProteinModelPortaliQ892X1.
    SMRiQ892X1. Positions 17-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    KOiK01933.
    OMAiPRIYGND.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q892X1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATYKDAGVN IEEGYKSVNL MKEHVQKTFN KGVLNGIGSF AAMYELGKYK    50
    NPVLVSGTDG VGTKLKIAFE LEKYNTIGID CVAMCVNDIL CHGAKPLFFL 100
    DYMACGKLKG EVAADIVKGV SDGCLRAGCA LIGGETAEMP GFYKEGEYDI 150
    AGFAVGIVEK ENIVDGQDIK EGDVLIGIAS SGVHSNGYSL VRSVIKDFRE 200
    EFHGKIIGEE LLTPTKIYVK PVLQLLKSYP IKGMAHITGG GFYENIPRMF 250
    KDDLNVVISK NSFPRPDIFE YIISKGIEEN HMFNVFNMGI GFVLCVDPCY 300
    EKKIIEKLIE QGEKAYKIGH IEKGERKVII K 331
    Length:331
    Mass (Da):36,424
    Last modified:June 1, 2003 - v1
    Checksum:iB03A0FAA96973EB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36471.1.
    RefSeqiNP_782534.1. NC_004557.1.

    Genome annotation databases

    EnsemblBacteriaiAAO36471; AAO36471; CTC_01964.
    GeneIDi1060242.
    KEGGictc:CTC01964.
    PATRICi19511979. VBICloTet101274_2037.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36471.1 .
    RefSeqi NP_782534.1. NC_004557.1.

    3D structure databases

    ProteinModelPortali Q892X1.
    SMRi Q892X1. Positions 17-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212717.CTC01964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO36471 ; AAO36471 ; CTC_01964 .
    GeneIDi 1060242.
    KEGGi ctc:CTC01964.
    PATRICi 19511979. VBICloTet101274_2037.

    Phylogenomic databases

    eggNOGi COG0150.
    KOi K01933.
    OMAi PRIYGND.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci CTET212717:GJAM-1801-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Massachusetts / E88.

    Entry informationi

    Entry nameiPUR5_CLOTE
    AccessioniPrimary (citable) accession number: Q892X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3