Reviewed, UniProtKB/Swiss-Prot Q892U4 (DEOC_CLOTE)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	CTC_01994

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_0000057228
Sites
	Active site	152	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	181	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q892U4-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 57653EEFEA2C5003	FASTA	216	23,516
	10 20 30 40 50 60 MEIQKFIDHT ILKPEATEEQ VKKLCKEARD YKFASVCVNP YYTSLVSKEL QGTDVKTCVV 70 80 90 100 110 120 IGFPLGANTK EVKAFETKQA IENGAKEVDM VINIGALKDK KYDVVKEDIE AVVNEAKGKA 130 140 150 160 170 180 LVKVIIETCL LTDEEKVKAC EISKEVGADF VKTSTGFSTG GAKKEDVKLM RETVGENIGV 190 200 210 KASGGIRDYK TSLEMIEAGA NRIGASAGIK IVEESK

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO36500.1.
RefSeq	NP_782563.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1059162.
GenomeReviews	Gene locus CTC_01994 in contig AE015927_GR.
KEGG	ctc:CTC01994.
NMPDR	fig|212717.1.peg.1785.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q892U4.
OMA	AKMIDHT.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_01994-MON.
BRENDA	4.1.2.4. 2082.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_CLOTE

Accession

Primary (citable) accession number: Q892U4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)