Reviewed, UniProtKB/Swiss-Prot Q892J5 (COAE_CLOTE)

Names and origin

Protein names

Recommended name:
    Dephospho-CoA kinase
    EC=2.7.1.24
Alternative name(s):
    Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	CTC_02101

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity.
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the coaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000172932
Regions
	Domain	31 – 227	197	DPCK
	Nucleotide binding	36 – 43	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q892J5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E8E4856A0ACCC060	FASTA	227	26,611
	10 20 30 40 50 60 MKEKIGMMLS DVDLEWLKKK YCIKNKGKFL KIGLTGGIGS GKSTISKMFK NMGIDVIDAD 70 80 90 100 110 120 KIAREVLEKY PPILEYIEEN FGEQYIDEFG NLNRREFGNH IFSISKKERE KYENIIIPYI 130 140 150 160 170 180 KLEIENQFKL YEKIGKKVCL LDAPLLIEQD MQKDLDFTVL SWVNKETQIK RVGIRDNLSE 190 200 210 220 DEILNRIEAQ ISLDKKRELV DFIIDNSNTI EETRVQVEKL FQFINCL

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO36600.1.
RefSeq	NP_782663.1.
3D structure databases
HSSP	HSSP built from PDB template 1N3B based on UniProtKB P36679.
ModBase	Search...
Genome annotation databases
GeneID	1060263.
GenomeReviews	Gene locus CTC_02101 in contig AE015927_GR.
KEGG	ctc:CTC02101.
NMPDR	fig|212717.1.peg.1885.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q892J5.
OMA	Q892J5. DICTEIW.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_02101-MON.
BRENDA	2.7.1.24. 2082.
Family and domain databases
HAMAP	MF_00376. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
PANTHER	PTHR10695. Depp_CoAkinase. 1 hit.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
ProDom	PD003329. Depp_CoAkinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00152. Depp_CoAkinase. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_CLOTE

Accession

Primary (citable) accession number: Q892J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)