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Q891R3

- FTHS_CLOTE

UniProt

Q891R3 - FTHS_CLOTE

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTET212717:GJAM-2117-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CTC_02304
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000199341Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC02304.

Structurei

3D structure databases

ProteinModelPortaliQ891R3.
SMRiQ891R3. Positions 7-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiCETGNIM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q891R3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKVLTDIEI AQKAQMKPIG EIAEKYGILE DELELYGKYK AKLSLDIFDR
60 70 80 90 100
LKDEKDGKLV LVTAISPTPA GEGKSTTSIG LGQALNKIGK KTFIALREPS
110 120 130 140 150
LGPVFGVKGG AAGGGYAQVV PMEDINLHFT GDMHAIGITN NLLSAAIDNH
160 170 180 190 200
IHQGNALKID SREIVWKRVV DMNDRALRNV VVGMGGKACG FTRQDGFMIT
210 220 230 240 250
VASEVMAILC LAKDLMDLKE RLGNIIVAYS LEGKPVTAGD LKVNGAMAML
260 270 280 290 300
LKDAIKPNIV QTLENTPALI HGGPFANIAH GCNSLIATRL GLKLGDILVT
310 320 330 340 350
EAGFGADLGA EKFLDIKCRY GGLKPDAVVI VATIRALKMH GGVKKTELSG
360 370 380 390 400
ENLEALDKGF ANLQKHITNM KNFGLPVMVA VNRFITDSEA EIDLLIKKCK
410 420 430 440 450
EIGVEVSLNE VWAKGGEGGI EMAEKLVKIL ETEKPNYKPL YDVEDSIPEK
460 470 480 490 500
LNKIVKELYG GEGVVIESSA MKQIKKLEEI GLDKLPICMA KTQFSFSDDA
510 520 530 540 550
TLMGAPKGFN ITIKNVRVSA GAGFIVCETG NIMVMPGLPK VPAAEKMDVD

ENGNISGLF
Length:559
Mass (Da):60,073
Last modified:June 1, 2003 - v1
Checksum:i5FF7F0F0943AF04B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36782.1.
RefSeqiNP_782845.1. NC_004557.1.
WP_011100443.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO36782; AAO36782; CTC_02304.
GeneIDi1060481.
KEGGictc:CTC02304.
PATRICi19512709. VBICloTet101274_2397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36782.1 .
RefSeqi NP_782845.1. NC_004557.1.
WP_011100443.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q891R3.
SMRi Q891R3. Positions 7-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212717.CTC02304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO36782 ; AAO36782 ; CTC_02304 .
GeneIDi 1060481.
KEGGi ctc:CTC02304.
PATRICi 19512709. VBICloTet101274_2397.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi CETGNIM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CTET212717:GJAM-2117-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiFTHS_CLOTE
AccessioniPrimary (citable) accession number: Q891R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3