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Q891R3 (FTHS_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:CTC_02304
OrganismClostridium tetani (strain Massachusetts / E88) [Complete proteome] [HAMAP]
Taxonomic identifier212717 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199341

Regions

Nucleotide binding68 – 758ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q891R3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5FF7F0F0943AF04B

FASTA55960,073
        10         20         30         40         50         60 
MEKVLTDIEI AQKAQMKPIG EIAEKYGILE DELELYGKYK AKLSLDIFDR LKDEKDGKLV 

        70         80         90        100        110        120 
LVTAISPTPA GEGKSTTSIG LGQALNKIGK KTFIALREPS LGPVFGVKGG AAGGGYAQVV 

       130        140        150        160        170        180 
PMEDINLHFT GDMHAIGITN NLLSAAIDNH IHQGNALKID SREIVWKRVV DMNDRALRNV 

       190        200        210        220        230        240 
VVGMGGKACG FTRQDGFMIT VASEVMAILC LAKDLMDLKE RLGNIIVAYS LEGKPVTAGD 

       250        260        270        280        290        300 
LKVNGAMAML LKDAIKPNIV QTLENTPALI HGGPFANIAH GCNSLIATRL GLKLGDILVT 

       310        320        330        340        350        360 
EAGFGADLGA EKFLDIKCRY GGLKPDAVVI VATIRALKMH GGVKKTELSG ENLEALDKGF 

       370        380        390        400        410        420 
ANLQKHITNM KNFGLPVMVA VNRFITDSEA EIDLLIKKCK EIGVEVSLNE VWAKGGEGGI 

       430        440        450        460        470        480 
EMAEKLVKIL ETEKPNYKPL YDVEDSIPEK LNKIVKELYG GEGVVIESSA MKQIKKLEEI 

       490        500        510        520        530        540 
GLDKLPICMA KTQFSFSDDA TLMGAPKGFN ITIKNVRVSA GAGFIVCETG NIMVMPGLPK 

       550 
VPAAEKMDVD ENGNISGLF 

« Hide

References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015927 Genomic DNA. Translation: AAO36782.1.
RefSeqNP_782845.1. NC_004557.1.

3D structure databases

ProteinModelPortalQ891R3.
SMRQ891R3. Positions 7-557.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING212717.CTC02304.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO36782; AAO36782; CTC_02304.
GeneID1060481.
KEGGctc:CTC02304.
PATRIC19512709. VBICloTet101274_2397.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMAAKININI.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycCTET212717:GJAM-2117-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CLOTE
AccessionPrimary (citable) accession number: Q891R3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways