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Q891R3

- FTHS_CLOTE

UniProt

Q891R3 - FTHS_CLOTE

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTET212717:GJAM-2117-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:CTC_02304
    OrganismiClostridium tetani (strain Massachusetts / E88)
    Taxonomic identifieri212717 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001412: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000199341Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi212717.CTC02304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ891R3.
    SMRiQ891R3. Positions 7-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiCETGNIM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q891R3-1 [UniParc]FASTAAdd to Basket

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    MEKVLTDIEI AQKAQMKPIG EIAEKYGILE DELELYGKYK AKLSLDIFDR    50
    LKDEKDGKLV LVTAISPTPA GEGKSTTSIG LGQALNKIGK KTFIALREPS 100
    LGPVFGVKGG AAGGGYAQVV PMEDINLHFT GDMHAIGITN NLLSAAIDNH 150
    IHQGNALKID SREIVWKRVV DMNDRALRNV VVGMGGKACG FTRQDGFMIT 200
    VASEVMAILC LAKDLMDLKE RLGNIIVAYS LEGKPVTAGD LKVNGAMAML 250
    LKDAIKPNIV QTLENTPALI HGGPFANIAH GCNSLIATRL GLKLGDILVT 300
    EAGFGADLGA EKFLDIKCRY GGLKPDAVVI VATIRALKMH GGVKKTELSG 350
    ENLEALDKGF ANLQKHITNM KNFGLPVMVA VNRFITDSEA EIDLLIKKCK 400
    EIGVEVSLNE VWAKGGEGGI EMAEKLVKIL ETEKPNYKPL YDVEDSIPEK 450
    LNKIVKELYG GEGVVIESSA MKQIKKLEEI GLDKLPICMA KTQFSFSDDA 500
    TLMGAPKGFN ITIKNVRVSA GAGFIVCETG NIMVMPGLPK VPAAEKMDVD 550
    ENGNISGLF 559
    Length:559
    Mass (Da):60,073
    Last modified:June 1, 2003 - v1
    Checksum:i5FF7F0F0943AF04B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36782.1.
    RefSeqiNP_782845.1. NC_004557.1.

    Genome annotation databases

    EnsemblBacteriaiAAO36782; AAO36782; CTC_02304.
    GeneIDi1060481.
    KEGGictc:CTC02304.
    PATRICi19512709. VBICloTet101274_2397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36782.1 .
    RefSeqi NP_782845.1. NC_004557.1.

    3D structure databases

    ProteinModelPortali Q891R3.
    SMRi Q891R3. Positions 7-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212717.CTC02304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO36782 ; AAO36782 ; CTC_02304 .
    GeneIDi 1060481.
    KEGGi ctc:CTC02304.
    PATRICi 19512709. VBICloTet101274_2397.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi CETGNIM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CTET212717:GJAM-2117-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Massachusetts / E88.

    Entry informationi

    Entry nameiFTHS_CLOTE
    AccessioniPrimary (citable) accession number: Q891R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3