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Q891J1

- PYRF_CLOTE

UniProt

Q891J1 - PYRF_CLOTE

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciCTET212717:GJAM-2189-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:CTC_02381
    OrganismiClostridium tetani (strain Massachusetts / E88)
    Taxonomic identifieri212717 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001412: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Orotidine 5'-phosphate decarboxylasePRO_1000066467Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi212717.CTC02381.

    Structurei

    3D structure databases

    ProteinModelPortaliQ891J1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    KOiK01591.
    OMAiHIHARHP.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q891J1-1 [UniParc]FASTAAdd to Basket

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    MMIDKLYKRV EKNGHVCAGL DTSLDYIPEY FKTKYFNEED IIFNFNKEII    50
    DATYDKVACF KIQIAYYEAL GLKGLRAYKR TLDYIKESDG IVISDIKRGD 100
    ISSTAKMYAR AHFEGDFETD FITLSPYMGL DSIEPYFEYM KQKGKGVFVL 150
    VRTSNEGAKD IEFIESKDGN KVYEIIGKKL KNMGQDFLGN CGYSSIGGVV 200
    GCTHIDEAVK LRKDLGGMFF LIPGYGAQGG KAEDVALYLK NGNGGVVNSS 250
    RGILLAYKKQ NDEKNFAKCS RNEVIRMRDD ILQAINSK 288
    Length:288
    Mass (Da):32,456
    Last modified:June 1, 2003 - v1
    Checksum:iE3C843E0AB5E1F64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36854.1.
    RefSeqiNP_782917.1. NC_004557.1.
    WP_011100515.1. NC_004557.1.

    Genome annotation databases

    EnsemblBacteriaiAAO36854; AAO36854; CTC_02381.
    GeneIDi1060561.
    KEGGictc:CTC02381.
    PATRICi19512859. VBICloTet101274_2472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO36854.1 .
    RefSeqi NP_782917.1. NC_004557.1.
    WP_011100515.1. NC_004557.1.

    3D structure databases

    ProteinModelPortali Q891J1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212717.CTC02381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO36854 ; AAO36854 ; CTC_02381 .
    GeneIDi 1060561.
    KEGGi ctc:CTC02381.
    PATRICi 19512859. VBICloTet101274_2472.

    Phylogenomic databases

    eggNOGi COG0284.
    KOi K01591.
    OMAi HIHARHP.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci CTET212717:GJAM-2189-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Massachusetts / E88.

    Entry informationi

    Entry nameiPYRF_CLOTE
    AccessioniPrimary (citable) accession number: Q891J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3