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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCTET212717:G1G04-2459-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:CTC_02381
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001412 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000664671 – 288Orotidine 5'-phosphate decarboxylaseAdd BLAST288

Proteomic databases

PRIDEiQ891J1

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC02381

Structurei

3D structure databases

ProteinModelPortaliQ891J1
SMRiQ891J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

Q891J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIDKLYKRV EKNGHVCAGL DTSLDYIPEY FKTKYFNEED IIFNFNKEII
60 70 80 90 100
DATYDKVACF KIQIAYYEAL GLKGLRAYKR TLDYIKESDG IVISDIKRGD
110 120 130 140 150
ISSTAKMYAR AHFEGDFETD FITLSPYMGL DSIEPYFEYM KQKGKGVFVL
160 170 180 190 200
VRTSNEGAKD IEFIESKDGN KVYEIIGKKL KNMGQDFLGN CGYSSIGGVV
210 220 230 240 250
GCTHIDEAVK LRKDLGGMFF LIPGYGAQGG KAEDVALYLK NGNGGVVNSS
260 270 280
RGILLAYKKQ NDEKNFAKCS RNEVIRMRDD ILQAINSK
Length:288
Mass (Da):32,456
Last modified:June 1, 2003 - v1
Checksum:iE3C843E0AB5E1F64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA Translation: AAO36854.1
RefSeqiWP_011100515.1, NC_004557.1

Genome annotation databases

EnsemblBacteriaiAAO36854; AAO36854; CTC_02381
GeneIDi24252722
KEGGictc:CTC_02381

Similar proteinsi

Entry informationi

Entry nameiPYRF_CLOTE
AccessioniPrimary (citable) accession number: Q891J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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