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Q891J1

- PYRF_CLOTE

UniProt

Q891J1 - PYRF_CLOTE

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton donorUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCTET212717:GJAM-2189-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:CTC_02381
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001412: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Orotidine 5'-phosphate decarboxylasePRO_1000066467Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi212717.CTC02381.

Structurei

3D structure databases

ProteinModelPortaliQ891J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiHIHARHP.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q891J1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMIDKLYKRV EKNGHVCAGL DTSLDYIPEY FKTKYFNEED IIFNFNKEII
60 70 80 90 100
DATYDKVACF KIQIAYYEAL GLKGLRAYKR TLDYIKESDG IVISDIKRGD
110 120 130 140 150
ISSTAKMYAR AHFEGDFETD FITLSPYMGL DSIEPYFEYM KQKGKGVFVL
160 170 180 190 200
VRTSNEGAKD IEFIESKDGN KVYEIIGKKL KNMGQDFLGN CGYSSIGGVV
210 220 230 240 250
GCTHIDEAVK LRKDLGGMFF LIPGYGAQGG KAEDVALYLK NGNGGVVNSS
260 270 280
RGILLAYKKQ NDEKNFAKCS RNEVIRMRDD ILQAINSK
Length:288
Mass (Da):32,456
Last modified:June 1, 2003 - v1
Checksum:iE3C843E0AB5E1F64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36854.1.
RefSeqiNP_782917.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO36854; AAO36854; CTC_02381.
GeneIDi1060561.
KEGGictc:CTC02381.
PATRICi19512859. VBICloTet101274_2472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE015927 Genomic DNA. Translation: AAO36854.1 .
RefSeqi NP_782917.1. NC_004557.1.

3D structure databases

ProteinModelPortali Q891J1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 212717.CTC02381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO36854 ; AAO36854 ; CTC_02381 .
GeneIDi 1060561.
KEGGi ctc:CTC02381.
PATRICi 19512859. VBICloTet101274_2472.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi HIHARHP.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CTET212717:GJAM-2189-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Massachusetts / E88.

Entry informationi

Entry nameiPYRF_CLOTE
AccessioniPrimary (citable) accession number: Q891J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3