Reviewed, UniProtKB/Swiss-Prot Q891I4 (NTPA_CLOTE)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CTC_02388

Organism

Clostridium tetani [Complete proteome] [HAMAP]

Taxonomic identifier

1513 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178156

Sequences

	Sequence		Length	Mass (Da)
	Q891I4-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B75509761D6A3AEF	FASTA	201	22,469
	10 20 30 40 50 60 MKTVLLATNN ENKVNEIKDI LCELNLKVVS LKEVGINVEV EEDELTFMGN ALKKALTLYN 70 80 90 100 110 120 MIDDKKYMVL ADDSGLSVDV LGGAPGVFSA RYAGEHGNSK ANNEKLLEDM KGLKNRKGKF 130 140 150 160 170 180 ICAMALVIDK DNIIKVQGEV EGSIGYEEKG DNGFGYDPLF FVSKYNMTFA EMDKDIKNSI 190 200 SHRRDALNKI KEKLKSYIED K

References

[1]

"The genome sequence of Clostridium tetani, the causative agent of tetanus disease." Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Massachusetts / E88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE015927 Genomic DNA. Translation: AAO36861.1.
RefSeq	NP_782924.1.
3D structure databases
HSSP	HSSP built from PDB template 1K7K based on UniProtKB P52061.
ModBase	Search...
Genome annotation databases
GeneID	1060573.
GenomeReviews	Gene locus CTC_02388 in contig AE015927_GR.
KEGG	ctc:CTC02388.
NMPDR	fig|212717.1.peg.2146.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q891I4.
OMA	Q891I4. VYTADWA.
Enzyme and pathway databases
BioCyc	CTET212717:CTC_02388-MON.
BRENDA	3.6.1.15. 2082.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_CLOTE

Accession

Primary (citable) accession number: Q891I4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)