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Reviewed, UniProtKB/Swiss-Prot Q891I4 (NTPA_CLOTE)

Last modified June 16, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase
Gene names
Ordered Locus Names: CTC_02388
OrganismClostridium tetani [Complete proteome] [HAMAP]
Taxonomic identifier1513 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.

Catalytic activity

NTP + H2O = NDP + phosphate. HAMAP MF_01405

Cofactor

Divalent cations By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the HAM1 NTPase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionnucleoside-triphosphatase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Nucleoside-triphosphatase HAMAP MF_01405
PRO_0000178156

Sequences

Sequence LengthMass (Da)Tools
Q891I4-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B75509761D6A3AEF

FASTA20122,469
        10         20         30         40         50         60 
MKTVLLATNN ENKVNEIKDI LCELNLKVVS LKEVGINVEV EEDELTFMGN ALKKALTLYN 

        70         80         90        100        110        120 
MIDDKKYMVL ADDSGLSVDV LGGAPGVFSA RYAGEHGNSK ANNEKLLEDM KGLKNRKGKF 

       130        140        150        160        170        180 
ICAMALVIDK DNIIKVQGEV EGSIGYEEKG DNGFGYDPLF FVSKYNMTFA EMDKDIKNSI 

       190        200 
SHRRDALNKI KEKLKSYIED K 

« Hide

References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

AE015927 Genomic DNA. Translation: AAO36861.1.
RefSeqNP_782924.1.

3D structure databases

HSSPHSSP built from PDB template 1K7K based on UniProtKB P52061.
ModBaseSearch...

Genome annotation databases

GeneID1060573.
GenomeReviewsGene locus CTC_02388 in contig AE015927_GR.
KEGGctc:CTC02388.
NMPDRfig|212717.1.peg.2146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ891I4.
OMAQ891I4. VYTADWA.

Enzyme and pathway databases

BioCycCTET212717:CTC_02388-MON.
BRENDA3.6.1.15. 2082.

Family and domain databases

HAMAPMF_01405.
[Tree]
InterProIPR002637. Ham1p-like.
[Graphical view]
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. Ham1p_like. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_CLOTE
AccessionPrimary (citable) accession number: Q891I4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents