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Q891I4 (NTPA_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:CTC_02388
OrganismClostridium tetani [Complete proteome] [HAMAP]
Taxonomic identifier1513 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
PRO_0000178156

Regions

Region8 – 136Substrate binding By similarity
Region73 – 742Substrate binding By similarity

Sites

Metal binding411Magnesium or manganese By similarity
Metal binding731Magnesium or manganese By similarity
Binding site1571Substrate By similarity
Binding site1771Substrate By similarity
Binding site1831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q891I4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B75509761D6A3AEF

FASTA20122,469
        10         20         30         40         50         60 
MKTVLLATNN ENKVNEIKDI LCELNLKVVS LKEVGINVEV EEDELTFMGN ALKKALTLYN 

        70         80         90        100        110        120 
MIDDKKYMVL ADDSGLSVDV LGGAPGVFSA RYAGEHGNSK ANNEKLLEDM KGLKNRKGKF 

       130        140        150        160        170        180 
ICAMALVIDK DNIIKVQGEV EGSIGYEEKG DNGFGYDPLF FVSKYNMTFA EMDKDIKNSI 

       190        200 
SHRRDALNKI KEKLKSYIED K 

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References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed: 12552129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015927 Genomic DNA. Translation: AAO36861.1.
RefSeqNP_782924.1. NC_004557.1.

3D structure databases

ProteinModelPortalQ891I4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1060573.
GenomeReviewsGene locus CTC_02388 in contig AE015927_GR.
KEGGctc:CTC02388.
NMPDRfig|212717.1.peg.2146.
PATRIC19512893. VBICloTet101274_2478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697237.
OMAGVYTADW.
PhylomeDBQ891I4.
ProtClustDBPRK00120.

Enzyme and pathway databases

BioCycCTET212717:CTC_02388-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_CLOTE
AccessionPrimary (citable) accession number: Q891I4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families