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Q891H2 (G6PI_CLOTE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CTC_02404
OrganismClostridium tetani (strain Massachusetts / E88) [Complete proteome] [HAMAP]
Taxonomic identifier212717 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180628

Sites

Active site2901Proton donor By similarity
Active site3111 By similarity
Active site4251 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q891H2 [UniParc].

Last modified May 23, 2003. Version 1.
Checksum: C4714F5240DF251C

FASTA44950,672
        10         20         30         40         50         60 
MNKITVDLNN TKPYIKDEEI KALEPFIKEA HKMLHEGSGL GNDFIGWLDL PINYDKDEFQ 

        70         80         90        100        110        120 
RIKKASNKIK ANSDILLVIG IGGSYLGARA AIEMLSHNFR SLLKKEDKEG TDIIFVGNSI 

       130        140        150        160        170        180 
SSTYMAELLE VIKDRDFSIN VISKSGTTTE PAIAFRIFKE ILENKYGIEE AKNRIFVTTD 

       190        200        210        220        230        240 
KSKGALKTSS DKQGYETFVI PDNVGGRYSV LTAVGLLPIS VAGINIDEML KGAYDAREDF 

       250        260        270        280        290        300 
MYDNIEENQC YKYVAARNAL YNKGKNTEIL ANFEPSLHYF GEWWKQLYGE SEGKEGKGIF 

       310        320        330        340        350        360 
PASVSFSTDL HSMGQYIQEG LRIIFETFIN IEKPRKDLEI KSEKENLDGL NFLSGKTVDF 

       370        380        390        400        410        420 
VNKQAFRGTV LAHNDGEVPC IVINVPEVSP YYFGYLVYFF EKACGISGYI LGVNPFDQPG 

       430        440 
VEAYKKNMFA LLGKEGFEDR KKELEKRMN 

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References

[1]"The genome sequence of Clostridium tetani, the causative agent of tetanus disease."
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Massachusetts / E88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE015927 Genomic DNA. Translation: AAO36873.1.
RefSeqNP_782936.1. NC_004557.1.

3D structure databases

ProteinModelPortalQ891H2.
SMRQ891H2. Positions 4-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING212717.CTC02404.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO36873; AAO36873; CTC_02404.
GeneID1060584.
KEGGctc:CTC02404.
PATRIC19512923. VBICloTet101274_2493.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMAFIFENIC.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycCTET212717:GJAM-2219-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CLOTE
AccessionPrimary (citable) accession number: Q891H2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways