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Q890U2

- GLMS_CLOTE

UniProt

Q890U2 - GLMS_CLOTE

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei603 – 6031For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciCTET212717:GJAM-2350-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:CTC_02543
    OrganismiClostridium tetani (strain Massachusetts / E88)
    Taxonomic identifieri212717 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001412: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135324Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi212717.CTC02543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ890U2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini284 – 424141SIS 1UniRule annotationAdd
    BLAST
    Domaini453 – 598146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiSVFETQT.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q890U2-1 [UniParc]FASTAAdd to Basket

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    MCGIVGYIGK KEAAPILVEG LSKLEYRGYD SAGVAIIEDQ VIRTRKCKGR    50
    LVNLEEKLNE ESMIGDIGIG HTRWATHGEP SDKNSHPHNN EKGTISVVHN 100
    GIIENYIELR EWLTSEGYKF VSETDTEVLP HLIDYYYKGD LLEAVMTAIS 150
    KVEGSYAIGV VCSEEPDKVV AVRKDSPLIV GLGEEEYFIA SDIPAVLNHT 200
    RDIYLLKDNE FVLMTKDGVK LFDKEGKEIK REIYHVTWNA DAAEKGGYDH 250
    FMLKEIHEQP KVIKDTMTSR IMLGKDIKLD NIEISKEQME KINKIYIVAC 300
    GTAYHAGLVG KYTIEKLARI PVEVDIASEF RYKNPIIDKD TLMIVISQSG 350
    ETADTLAALR EAKKKGARVI AVTNVVGSSI SREADDILYT WAGPEIAVAS 400
    TKAYETQLVA MYILALYFAQ EKGTLNKEEL EELKEEMLSI PDKAEKCLET 450
    DEIMKKLASK THMKKDMFFL GRGLDYAVAL EGSLKLKEIS YIHSEAYAAG 500
    ELKHGPIALI EEGTIVITLA TQEELFDKTV SNIKEVTTRG AKAIGIAFEG 550
    QKNMDKAVEE AIYIPKTKSI FAPLLSVIPL QLYSYYVSLE KGCDVDKPRN 600
    LAKSVTVE 608
    Length:608
    Mass (Da):67,826
    Last modified:January 23, 2007 - v2
    Checksum:i01F969978DE4D07E
    GO

    Sequence cautioni

    The sequence AAO37003.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO37003.1. Different initiation.
    RefSeqiNP_783066.1. NC_004557.1.

    Genome annotation databases

    EnsemblBacteriaiAAO37003; AAO37003; CTC_02543.
    GeneIDi1060148.
    KEGGictc:CTC02543.
    PATRICi19513205. VBICloTet101274_2633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO37003.1 . Different initiation.
    RefSeqi NP_783066.1. NC_004557.1.

    3D structure databases

    ProteinModelPortali Q890U2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212717.CTC02543.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO37003 ; AAO37003 ; CTC_02543 .
    GeneIDi 1060148.
    KEGGi ctc:CTC02543.
    PATRICi 19513205. VBICloTet101274_2633.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi SVFETQT.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci CTET212717:GJAM-2350-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Massachusetts / E88.

    Entry informationi

    Entry nameiGLMS_CLOTE
    AccessioniPrimary (citable) accession number: Q890U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3