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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei603For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CTC_02543
OrganismiClostridium tetani (strain Massachusetts / E88)
Taxonomic identifieri212717 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001412 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353242 – 608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST607

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi212717.CTC02543.

Structurei

3D structure databases

ProteinModelPortaliQ890U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini284 – 424SIS 1UniRule annotationAdd BLAST141
Domaini453 – 598SIS 2UniRule annotationAdd BLAST146

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiPOG091H0061.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q890U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGK KEAAPILVEG LSKLEYRGYD SAGVAIIEDQ VIRTRKCKGR
60 70 80 90 100
LVNLEEKLNE ESMIGDIGIG HTRWATHGEP SDKNSHPHNN EKGTISVVHN
110 120 130 140 150
GIIENYIELR EWLTSEGYKF VSETDTEVLP HLIDYYYKGD LLEAVMTAIS
160 170 180 190 200
KVEGSYAIGV VCSEEPDKVV AVRKDSPLIV GLGEEEYFIA SDIPAVLNHT
210 220 230 240 250
RDIYLLKDNE FVLMTKDGVK LFDKEGKEIK REIYHVTWNA DAAEKGGYDH
260 270 280 290 300
FMLKEIHEQP KVIKDTMTSR IMLGKDIKLD NIEISKEQME KINKIYIVAC
310 320 330 340 350
GTAYHAGLVG KYTIEKLARI PVEVDIASEF RYKNPIIDKD TLMIVISQSG
360 370 380 390 400
ETADTLAALR EAKKKGARVI AVTNVVGSSI SREADDILYT WAGPEIAVAS
410 420 430 440 450
TKAYETQLVA MYILALYFAQ EKGTLNKEEL EELKEEMLSI PDKAEKCLET
460 470 480 490 500
DEIMKKLASK THMKKDMFFL GRGLDYAVAL EGSLKLKEIS YIHSEAYAAG
510 520 530 540 550
ELKHGPIALI EEGTIVITLA TQEELFDKTV SNIKEVTTRG AKAIGIAFEG
560 570 580 590 600
QKNMDKAVEE AIYIPKTKSI FAPLLSVIPL QLYSYYVSLE KGCDVDKPRN

LAKSVTVE
Length:608
Mass (Da):67,826
Last modified:January 23, 2007 - v2
Checksum:i01F969978DE4D07E
GO

Sequence cautioni

The sequence AAO37003 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA. Translation: AAO37003.1. Different initiation.
RefSeqiWP_035111559.1. NC_004557.1.

Genome annotation databases

EnsemblBacteriaiAAO37003; AAO37003; CTC_02543.
GeneIDi24253418.
KEGGictc:CTC_02543.
PATRICi19513205. VBICloTet101274_2633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015927 Genomic DNA. Translation: AAO37003.1. Different initiation.
RefSeqiWP_035111559.1. NC_004557.1.

3D structure databases

ProteinModelPortaliQ890U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi212717.CTC02543.

Protein family/group databases

MEROPSiC44.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO37003; AAO37003; CTC_02543.
GeneIDi24253418.
KEGGictc:CTC_02543.
PATRICi19513205. VBICloTet101274_2633.

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiGEFFCAS.
OrthoDBiPOG091H0061.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_CLOTE
AccessioniPrimary (citable) accession number: Q890U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.