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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hydroxyethylthiazole kinase (thiM)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41Substrate; via amide nitrogenUniRule annotation1
Binding sitei117ATPUniRule annotation1
Binding sitei163ATPUniRule annotation1
Binding sitei190Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processThiamine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLPLA220668:G1GW0-89-MONOMER
UniPathwayiUPA00060; UER00139

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:lp_0113
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001569401 – 263Hydroxyethylthiazole kinaseAdd BLAST263

Interactioni

Protein-protein interaction databases

STRINGi220668.lp_0113

Structurei

3D structure databases

ProteinModelPortaliQ890C2
SMRiQ890C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4U Bacteria
COG2145 LUCA
HOGENOMiHOG000114352
KOiK00878
OMAiATGQKDF

Family and domain databases

CDDicd01170 THZ_kinase, 1 hit
Gene3Di3.40.1190.201 hit
HAMAPiMF_00228 Thz_kinase, 1 hit
InterProiView protein in InterPro
IPR000417 Hyethyz_kinase
IPR029056 Ribokinase-like
PANTHERiPTHR44423 PTHR44423, 1 hit
PfamiView protein in Pfam
PF02110 HK, 1 hit
PIRSFiPIRSF000513 Thz_kinase, 1 hit
PRINTSiPR01099 HYETHTZKNASE
SUPFAMiSSF53613 SSF53613, 1 hit

Sequencei

Sequence statusi: Complete.

Q890C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQLLNTLR NHNPIVFNIA NFVTVQDVAN GLNALGASPI MSAEVQEAET
60 70 80 90 100
MVQIAGAVCI NLGTLTTTQI DQMRVVGKLA NQYHKPVVLD PVAVGAVPYR
110 120 130 140 150
KEVALALLSD FQVDVIRGNA GEIAALAGMD WQAKGIDAGS GQGDLVEIAQ
160 170 180 190 200
ACAQQFQCCV ILSGPTDVIT DGQRVVKVAN GTPLFQRHVG SGDLLSSIVA
210 220 230 240 250
AFTAVSPTDV YQAAQVACLV LAGAGELVAS QLTADRPATF AIDLIDRLSL
260
VTVSEIQTIA KVD
Length:263
Mass (Da):27,521
Last modified:June 1, 2003 - v1
Checksum:iCC4E65F7DC6FF44F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA Translation: CCC77667.1
RefSeqiWP_011100886.1, NC_004567.2
YP_004888181.1, NC_004567.2

Genome annotation databases

EnsemblBacteriaiCCC77667; CCC77667; lp_0113
GeneIDi1061358
KEGGilpl:lp_0113
PATRICifig|220668.9.peg.91

Similar proteinsi

Entry informationi

Entry nameiTHIM_LACPL
AccessioniPrimary (citable) accession number: Q890C2
Secondary accession number(s): F9UST6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome