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Q890C2 (THIM_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:lp_0113
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156940

Sites

Binding site411Substrate; via amide nitrogen By similarity
Binding site1171ATP By similarity
Binding site1631ATP By similarity
Binding site1901Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q890C2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: CC4E65F7DC6FF44F

FASTA26327,521
        10         20         30         40         50         60 
MELQLLNTLR NHNPIVFNIA NFVTVQDVAN GLNALGASPI MSAEVQEAET MVQIAGAVCI 

        70         80         90        100        110        120 
NLGTLTTTQI DQMRVVGKLA NQYHKPVVLD PVAVGAVPYR KEVALALLSD FQVDVIRGNA 

       130        140        150        160        170        180 
GEIAALAGMD WQAKGIDAGS GQGDLVEIAQ ACAQQFQCCV ILSGPTDVIT DGQRVVKVAN 

       190        200        210        220        230        240 
GTPLFQRHVG SGDLLSSIVA AFTAVSPTDV YQAAQVACLV LAGAGELVAS QLTADRPATF 

       250        260 
AIDLIDRLSL VTVSEIQTIA KVD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC77667.1.
RefSeqYP_004888181.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ890C2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING220668.lp_0113.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC77667; CCC77667; lp_0113.
GeneID1061358.
KEGGlpl:lp_0113.
PATRIC22246809. VBILacPla27411_0091.

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAFDENIEM.
ProtClustDBPRK09355.

Enzyme and pathway databases

UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_LACPL
AccessionPrimary (citable) accession number: Q890C2
Secondary accession number(s): F9UST6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways