Reviewed, UniProtKB/Swiss-Prot Q88ZS1 (MTLD_LACPL)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	lp_0233

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000170709
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88ZS1-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1B174ECC6B5D2C8B	FASTA	385	43,200
	10 20 30 40 50 60 MLDVHFGAGN IGRGFIGETL ADNGFKITFV DVNDTLIDEL NKRNGYTIEL AAEGQKHIEV 70 80 90 100 110 120 HDVKGINNGK DPKAVAEEIA QADMVTTAIG PKILKFIAPL IADGLKLRQA NNNTTPIDII 130 140 150 160 170 180 ACENMIGGSQ SLKKSVYESL NEDEQAWADQ NAGFPNAAVD RIVPLQKHDD PLFVSVEPFK 190 200 210 220 230 240 EWVIDKSQMK NPKIQLKGVD YADDLEPYIE RKLFSVNTGH ATVAYTGNMK GYKTIGEAVK 250 260 270 280 290 300 DDSVVDQAKH VLGETGDLLI QKWGFDPEVH HAYQKKILSR FENPYISDDI ERVGRTPIRK 310 320 330 340 350 360 LGFNERFIRP IRELKERGRD YSALVDTVGE MFFFNYPNDS ESVKLQQLLK DEPIEQVIRE 370 380 TTDLKDEDLV NEIKAAYEKH LAAAK

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL935252 Genomic DNA. Translation: CAD62894.1.
RefSeq	NP_784055.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1061392.
GenomeReviews	Gene locus lp_0233 in contig AL935263_GR.
KEGG	lpl:lp_0233.
NMPDR	fig|220668.1.peg.189.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q88ZS1.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_0233-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_LACPL

Accession

Primary (citable) accession number: Q88ZS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)