Reviewed, UniProtKB/Swiss-Prot Q88ZS1 (MTLD_LACPL)

Names and originHide

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	lp_0233

Organism

Lactobacillus plantarum [Complete proteome] [HAMAP]

Taxonomic identifier

1590 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributesHide

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

OntologiesHide

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170709
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

SequencesHide

	Sequence		Length	Mass (Da)
	Q88ZS1-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1B174ECC6B5D2C8B	FASTA	385	43,200
	10 20 30 40 50 60 MLDVHFGAGN IGRGFIGETL ADNGFKITFV DVNDTLIDEL NKRNGYTIEL AAEGQKHIEV 70 80 90 100 110 120 HDVKGINNGK DPKAVAEEIA QADMVTTAIG PKILKFIAPL IADGLKLRQA NNNTTPIDII 130 140 150 160 170 180 ACENMIGGSQ SLKKSVYESL NEDEQAWADQ NAGFPNAAVD RIVPLQKHDD PLFVSVEPFK 190 200 210 220 230 240 EWVIDKSQMK NPKIQLKGVD YADDLEPYIE RKLFSVNTGH ATVAYTGNMK GYKTIGEAVK 250 260 270 280 290 300 DDSVVDQAKH VLGETGDLLI QKWGFDPEVH HAYQKKILSR FENPYISDDI ERVGRTPIRK 310 320 330 340 350 360 LGFNERFIRP IRELKERGRD YSALVDTVGE MFFFNYPNDS ESVKLQQLLK DEPIEQVIRE 370 380 TTDLKDEDLV NEIKAAYEKH LAAAK

ReferencesHide

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	AL935252 Genomic DNA. Translation: CAD62894.1.
RefSeq	NP_784055.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1061392.
GenomeReviews	Gene locus lp_0233 in contig AL935263_GR.
KEGG	lpl:lp_0233.
NMPDR	fig|220668.1.peg.189.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	FTVNTGH.
ProtClustDB	PRK02318.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_0233-MONOMER.
BRENDA	1.1.1.17. 593.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C_like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry informationHide

Entry name

MTLD_LACPL

Accession

Primary (citable) accession number: Q88ZS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	July 13, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)