Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q88Z84 (KPRS1_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase 1

Short name=RPPK 1
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 1
Short name=P-Rib-PP synthase 1
Short name=PRPP synthase 1
Gene names
Name:prs1
Ordered Locus Names:lp_0471
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) [Reference proteome] [HAMAP]
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583_B

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00583_B

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00583_B.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Ribose-phosphate pyrophosphokinase 1 HAMAP-Rule MF_00583_B
PRO_0000141148

Regions

Region218 – 23114Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1341Magnesium Potential
Metal binding1361Magnesium Potential
Metal binding1451Magnesium Potential
Metal binding1491Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q88Z84 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 28AC04BEAADCD656

FASTA32635,880
        10         20         30         40         50         60 
MSEQYFDPKL KIFALNSNKP LAEKIADAVG VKLGKTSVDR FSDGEIRINI EESIRGDQVY 

        70         80         90        100        110        120 
IIQSTSAPVN DNLMELLIMI DALRRASAKT INVVIPYYGY ARQDRKARSR EPITAKLVAN 

       130        140        150        160        170        180 
MLETAGATRI LALDLHAAQI QGFFDIPLDH LMGAPLLADY FLNHHLDENA VVVSPDHGGV 

       190        200        210        220        230        240 
TRARKLAEFL KAPIAIIDKR RPRANVAEVM NIIGDVKGKR AIMIDDMIDT AGTITLGAQA 

       250        260        270        280        290        300 
LVDAGATEVY ASCTHPVLSG PAIERIEKSP IKKLVVTDSI ELPAAKRIDK IEQVSVGQLM 

       310        320 
GQAIKFIHEN KPVSPLFKNR FHNEEN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC77970.1.
RefSeqYP_004888484.1. NC_004567.2.

3D structure databases

ProteinModelPortalQ88Z84.
SMRQ88Z84. Positions 2-317.
ModBaseSearch...

Protein-protein interaction databases

STRING220668.lp_0471.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC77970; CCC77970; lp_0471.
GeneID1061409.
KEGGlpl:lp_0471.
PATRIC22247401. VBILacPla27411_0387.

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAYVQIQES.
ProtClustDBPRK01259.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS1_LACPL
AccessionPrimary (citable) accession number: Q88Z84
Secondary accession number(s): F9UKV5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: June 1, 2003
Last modified: May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families