Reviewed,
UniProtKB/Swiss-Prot Q88Z84 (KPRS1_LACPL)
Last modified
November 3, 2009.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribose-phosphate pyrophosphokinase 1 Short name=RPPK 1 EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthetase 1 Short name=P-Rib-PP synthetase 1 Short name=PRPP synthetase 1 | ||||
| Gene names |
| ||||
| Organism | Lactobacillus plantarum [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1590 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus |
Protein attributes
| Sequence length | 326 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583 |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. |
| Pathway | Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activityInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: HAMAP ribose phosphate diphosphokinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 326 | 326 | Ribose-phosphate pyrophosphokinase 1 HAMAP MF_00583 | PRO_0000141148 | |||||
Regions | |||||||||
| Region | 218 – 231 | 14 | Binding of phosphoribosylpyrophosphate Potential | ||||||
Sites | |||||||||
| Metal binding | 134 | 1 | Magnesium Potential | ||||||
| Metal binding | 136 | 1 | Magnesium Potential | ||||||
| Metal binding | 145 | 1 | Magnesium Potential | ||||||
| Metal binding | 149 | 1 | Magnesium Potential | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1. |
Cross-references
Sequence databases | |
|---|---|
| AL935253 Genomic DNA. Translation: CAD63098.1. | |
| RefSeq | NP_784259.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DKU based on UniProtKB P14193. |
| SMR | Q88Z84. Positions 2-317. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1061409. |
| GenomeReviews | Gene locus lp_0471 in contig AL935263_GR. |
| KEGG | lpl:lp_0471. |
| NMPDR | fig|220668.1.peg.393. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q88Z84. |
| OMA | NVAEIMN. |
Enzyme and pathway databases | |
| BioCyc | LPLA220668:LP_0471-MON. |
| BRENDA | 2.7.6.1. 593. |
Family and domain databases | |
| HAMAP | MF_00583. [Tree] |
| InterPro | IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01251. ribP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KPRS1_LACPL | ||||||||
| Accession | Primary (citable) accession number: Q88Z84 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


