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Q88Z14 (NADE_LACPL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NH(3)-dependent NAD(+) synthetase

EC=6.3.1.5
Gene names
Name:nadE
Ordered Locus Names:lp_0566
OrganismLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifier220668 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193

Sequence similarities

Belongs to the NAD synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275NH(3)-dependent NAD(+) synthetase HAMAP MF_00193
PRO_1000077568

Regions

Nucleotide binding47 – 548ATP By similarity

Sites

Active site491 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q88Z14 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A1C78763ED7949D5

FASTA27530,590
        10         20         30         40         50         60 
MRPLQAEIIK ALHVAPTIDP EVEIRRSIDF LKAYLTKNTF LKTYVLGISG GQDSTLAGKL 

        70         80         90        100        110        120 
TEMAITEMRQ ETGDDRYQFI AVRLPYGNQA DEADAMAAID FMQADVTDRV DIQPATDAMV 

       130        140        150        160        170        180 
TALEANQLTI HDFNKGNIKA RQRMIVQYGI AGEMHGAVVG TDHAAEAVTG FYTKYGDGGA 

       190        200        210        220        230        240 
DIVPLWRLNK RQGKQMLAAL DAPKHLYDKV PTADLEEDRP ALPDEVALGV RYDDIDDYLE 

       250        260        270 
GRTVSDAAAE KIEAWYLKTA HKRHAAITVF DDFWK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL935263 Genomic DNA. Translation: CCC78052.1.
RefSeqNP_784340.1. NC_004567.1.

3D structure databases

HSSPHSSP built from PDB template 1WXI based on UniProtKB P18843.
ProteinModelPortalQ88Z14.
SMRQ88Z14. Positions 4-275.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1064235.
GenomeReviewsGene locus lp_0566 in contig AL935263_GR.
KEGGlpl:lp_0566.
NMPDRfig|220668.1.peg.474.
PATRIC22247585. VBILacPla27411_0470.

Phylogenomic databases

HOGENOMHBG351567.
OMAIAQYEIA.
ProtClustDBPRK00768.

Enzyme and pathway databases

BioCycLPLA220668:LP_0566-MONOMER.

Family and domain databases

HAMAPMF_00193. NadE.
[Tree]
InterProIPR022310. NAD/GMP_synthase.
IPR003694. NAD_synthase.
IPR022926. NH(3)-dep_NAD(+)_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01916.
PfamPF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00552. NadE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADE_LACPL
AccessionPrimary (citable) accession number: Q88Z14
Secondary accession number(s): F9UL37
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families