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Q88Z02

- PAND_LACPL

UniProt

Q88Z02 - PAND_LACPL

Protein

Aspartate 1-decarboxylase

Gene

panD

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.UniRule annotation

    Catalytic activityi

    L-aspartate = beta-alanine + CO2.UniRule annotation

    Cofactori

    Pyruvoyl group.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation
    Binding sitei57 – 571SubstrateUniRule annotation
    Active sitei58 – 581Proton donorUniRule annotation

    GO - Molecular functioni

    1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. alanine biosynthetic process Source: InterPro
    2. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    Pyruvate, Schiff base

    Enzyme and pathway databases

    BioCyciLPLA220668-WGS:GSPK-495-MONOMER.
    UniPathwayiUPA00028; UER00002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate 1-decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
    Alternative name(s):
    Aspartate alpha-decarboxylaseUniRule annotation
    Cleaved into the following 2 chains:
    Aspartate 1-decarboxylase beta chainUniRule annotation
    Aspartate 1-decarboxylase alpha chainUniRule annotation
    Gene namesi
    Name:panDUniRule annotation
    Ordered Locus Names:lp_0579
    OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
    Taxonomic identifieri220668 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000432: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2424Aspartate 1-decarboxylase beta chainUniRule annotationPRO_0000023111Add
    BLAST
    Chaini25 – 130106Aspartate 1-decarboxylase alpha chainUniRule annotationPRO_0000023112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Pyruvic acid (Ser)UniRule annotation

    Post-translational modificationi

    Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.UniRule annotation

    Keywords - PTMi

    Autocatalytic cleavage, Zymogen

    Interactioni

    Subunit structurei

    Heterooctamer of four alpha and four beta subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi220668.lp_0579.

    Structurei

    3D structure databases

    ProteinModelPortaliQ88Z02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 753Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PanD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0853.
    HOGENOMiHOG000221007.
    KOiK01579.
    OMAiSCAIDEN.

    Family and domain databases

    HAMAPiMF_00446. PanD.
    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view]
    PANTHERiPTHR21012. PTHR21012. 1 hit.
    PfamiPF02261. Asp_decarbox. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
    ProDomiPD009294. Asp_decarbox. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    TIGRFAMsiTIGR00223. panD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q88Z02-1 [UniParc]FASTAAdd to Basket

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    MLIDMLKGKI HRATVTQADL EYVGSITIDE TLMEASGILE YEKVQIADVN    50
    NGARFETYVI AGPRDSGVIC LNGATARCAS VGDKVIIMNY AQFEPEEAKH 100
    AKPYVVLVDD ENRLTKRVRY EKHGLLAEEL 130
    Length:130
    Mass (Da):14,458
    Last modified:June 1, 2003 - v1
    Checksum:i813A76450299104D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC78064.1.
    RefSeqiWP_011101061.1. NC_004567.2.
    YP_004888578.1. NC_004567.2.

    Genome annotation databases

    EnsemblBacteriaiCCC78064; CCC78064; lp_0579.
    GeneIDi1061538.
    KEGGilpl:lp_0579.
    PATRICi22247611. VBILacPla27411_0482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL935263 Genomic DNA. Translation: CCC78064.1 .
    RefSeqi WP_011101061.1. NC_004567.2.
    YP_004888578.1. NC_004567.2.

    3D structure databases

    ProteinModelPortali Q88Z02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220668.lp_0579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC78064 ; CCC78064 ; lp_0579 .
    GeneIDi 1061538.
    KEGGi lpl:lp_0579.
    PATRICi 22247611. VBILacPla27411_0482.

    Phylogenomic databases

    eggNOGi COG0853.
    HOGENOMi HOG000221007.
    KOi K01579.
    OMAi SCAIDEN.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00002 .
    BioCyci LPLA220668-WGS:GSPK-495-MONOMER.

    Family and domain databases

    HAMAPi MF_00446. PanD.
    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view ]
    PANTHERi PTHR21012. PTHR21012. 1 hit.
    Pfami PF02261. Asp_decarbox. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
    ProDomi PD009294. Asp_decarbox. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    TIGRFAMsi TIGR00223. panD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

    Entry informationi

    Entry nameiPAND_LACPL
    AccessioniPrimary (citable) accession number: Q88Z02
    Secondary accession number(s): F9UL49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3