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Q88Z02

- PAND_LACPL

UniProt

Q88Z02 - PAND_LACPL

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Protein
Aspartate 1-decarboxylase
Gene
panD, lp_0579
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine By similarity.UniRule annotation

Catalytic activityi

L-aspartate = beta-alanine + CO2.UniRule annotation

Cofactori

Pyruvoyl group By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acid By similarity
Binding sitei57 – 571Substrate By similarity
Active sitei58 – 581Proton donor By similarity

GO - Molecular functioni

  1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. alanine biosynthetic process Source: InterPro
  2. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

Pyruvate, Schiff base

Enzyme and pathway databases

BioCyciLPLA220668-WGS:GSPK-495-MONOMER.
UniPathwayiUPA00028; UER00002.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate 1-decarboxylase (EC:4.1.1.11)
Alternative name(s):
Aspartate alpha-decarboxylase
Cleaved into the following 2 chains:
Gene namesi
Name:panD
Ordered Locus Names:lp_0579
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000432: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2424Aspartate 1-decarboxylase beta chain By similarity
PRO_0000023111Add
BLAST
Chaini25 – 130106Aspartate 1-decarboxylase alpha chain By similarity
PRO_0000023112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyruvic acid (Ser) By similarity

Post-translational modificationi

Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus By similarity.UniRule annotation

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

Heterooctamer of four alpha and four beta subunits By similarity.

Protein-protein interaction databases

STRINGi220668.lp_0579.

Structurei

3D structure databases

ProteinModelPortaliQ88Z02.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 753Substrate binding By similarity

Sequence similaritiesi

Belongs to the PanD family.

Phylogenomic databases

eggNOGiCOG0853.
HOGENOMiHOG000221007.
KOiK01579.
OMAiSCAIDEN.

Family and domain databases

HAMAPiMF_00446. PanD.
InterProiIPR009010. Asp_de-COase-like_dom.
IPR003190. Asp_decarbox.
[Graphical view]
PANTHERiPTHR21012. PTHR21012. 1 hit.
PfamiPF02261. Asp_decarbox. 1 hit.
[Graphical view]
PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
ProDomiPD009294. Asp_decarbox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR00223. panD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q88Z02-1 [UniParc]FASTAAdd to Basket

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MLIDMLKGKI HRATVTQADL EYVGSITIDE TLMEASGILE YEKVQIADVN    50
NGARFETYVI AGPRDSGVIC LNGATARCAS VGDKVIIMNY AQFEPEEAKH 100
AKPYVVLVDD ENRLTKRVRY EKHGLLAEEL 130
Length:130
Mass (Da):14,458
Last modified:June 1, 2003 - v1
Checksum:i813A76450299104D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC78064.1.
RefSeqiWP_011101061.1. NC_004567.2.
YP_004888578.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC78064; CCC78064; lp_0579.
GeneIDi1061538.
KEGGilpl:lp_0579.
PATRICi22247611. VBILacPla27411_0482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL935263 Genomic DNA. Translation: CCC78064.1 .
RefSeqi WP_011101061.1. NC_004567.2.
YP_004888578.1. NC_004567.2.

3D structure databases

ProteinModelPortali Q88Z02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220668.lp_0579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC78064 ; CCC78064 ; lp_0579 .
GeneIDi 1061538.
KEGGi lpl:lp_0579.
PATRICi 22247611. VBILacPla27411_0482.

Phylogenomic databases

eggNOGi COG0853.
HOGENOMi HOG000221007.
KOi K01579.
OMAi SCAIDEN.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00002 .
BioCyci LPLA220668-WGS:GSPK-495-MONOMER.

Family and domain databases

HAMAPi MF_00446. PanD.
InterProi IPR009010. Asp_de-COase-like_dom.
IPR003190. Asp_decarbox.
[Graphical view ]
PANTHERi PTHR21012. PTHR21012. 1 hit.
Pfami PF02261. Asp_decarbox. 1 hit.
[Graphical view ]
PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
ProDomi PD009294. Asp_decarbox. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR00223. panD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Entry informationi

Entry nameiPAND_LACPL
AccessioniPrimary (citable) accession number: Q88Z02
Secondary accession number(s): F9UL49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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