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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1

Gene

accD1

Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2 (accD2), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1 (accD1)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13Zinc1
Metal bindingi16Zinc1
Metal bindingi31Zinc1
Metal bindingi34Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 34C4-typeAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciLPLA220668:G137Z-506-MONOMER.
UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1 (EC:6.4.1.2)
Short name:
ACCase subunit beta 1
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta 1
Gene namesi
Name:accD1
Ordered Locus Names:lp_0591
OrganismiLactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Taxonomic identifieri220668 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000432 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003897681 – 267Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1Add BLAST267

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

Protein-protein interaction databases

STRINGi220668.lp_0591.

Structurei

3D structure databases

ProteinModelPortaliQ88YZ2.
SMRiQ88YZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 267CoA carboxyltransferase N-terminalAdd BLAST259

Sequence similaritiesi

Belongs to the AccD/PCCB family.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri13 – 34C4-typeAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
HOGENOMiHOG000021671.
KOiK01963.
OMAiCAFDFRF.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q88YZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHYPASGTW QACPKCGRHV HQRQWGTYQQ CPYCHYWQRL TTAQRLEQLV
60 70 80 90 100
DEGSFQPLTM TERPVNQLGF PDYMNKLRRA QRQTGLNEAV VCGTALIEQQ
110 120 130 140 150
PCILAVMDSH FMMGTLNTAV TRRLLHASEQ ARAQRLPLII VTASGGARMQ
160 170 180 190 200
EGVYALVGMN LILAELARLA ATPLPLITVL TDPTMGGVSA SFAFKGDLII
210 220 230 240 250
AEAGAKIGFA GARVIQQTLP VKLPADFQTA DQLFKNGMVD AVVERPQLRS
260
TLGQALVNYG IGRSAHG
Length:267
Mass (Da):29,232
Last modified:June 1, 2003 - v1
Checksum:iD40A158E432C3211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935263 Genomic DNA. Translation: CCC78076.1.
RefSeqiWP_011101069.1. NC_004567.2.
YP_004888590.1. NC_004567.2.

Genome annotation databases

EnsemblBacteriaiCCC78076; CCC78076; lp_0591.
GeneIDi1061543.
KEGGilpl:lp_0591.
PATRICifig|220668.9.peg.495.

Similar proteinsi

Entry informationi

Entry nameiACCD1_LACPL
AccessioniPrimary (citable) accession number: Q88YZ2
Secondary accession number(s): F9UL61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families