Q88YY8 (GPMA1_LACPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1
Short name=BPG-dependent PGAM 1
Short name=PGAM 1
Short name=Phosphoglyceromutase 1
Short name=dPGM 1
EC=5.4.2.1

Gene names

Name:	gpmA1
Synonyms:	pgm2
Ordered Locus Names:	lp_0597

Organism

Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

Taxonomic identifier

220668 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 HAMAP MF_01039		PRO_0000179886
Sites
	Active site	9	1	Tele-phosphohistidine intermediate By similarity
	Active site	179	1	By similarity
	Site	60	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q88YY8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 209F01523D298432	FASTA	225	25,625
	10 20 30 40 50 60 MTELVLVRHG ESTANRDNTY TGWSDVPLTA VGIAQAHQAG KRLRATGLQF GAVHTSVLKR 70 80 90 100 110 120 AIVTANIMLS EIDQLWLPEY KTWRLNERHY GALRGQNKDV TRQEYGKAQV QQWRRSFYTV 130 140 150 160 170 180 PPLLTPAELD HDRRYTKYGA AVEPRGESLK MAYDRIMPYW IDEIAPRLLD GQNQLVVAHG 190 200 210 220 STLRAMIKYL EHISDTGIDG VEVANGVPIC YHLDRQLHVI GKEEY

References

[1]

"Complete genome sequence of Lactobacillus plantarum WCFS1." Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J. Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003) [PubMed: 12566566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-793 / NCIMB 8826 / WCFS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL935263 Genomic DNA. Translation: CCC78081.1.
RefSeq	NP_784369.1. NC_004567.1.
3D structure databases
ProteinModelPortal	Q88YY8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1061573.
GenomeReviews	Gene locus lp_0597 in contig AL935263_GR.
KEGG	lpl:lp_0597.
NMPDR	fig|220668.1.peg.503.
PATRIC	22247647. VBILacPla27411_0500.
Phylogenomic databases
HOGENOM	HBG658938.
OMA	ESTANRD.
ProtClustDB	CLSK581144.
Enzyme and pathway databases
BioCyc	LPLA220668:LP_0597-MONOMER.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA. [Tree]
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
KO	K01834.
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. Pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA1_LACPL

Accession

Primary (citable) accession number: Q88YY8
Secondary accession number(s): F9UL66

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program